Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"CD1d"”.
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CD1d restricted NKT cells in regulation of pathogenic autoimmunity
… NKT cells via the antigen presenting molecule CD1d have so far been identified as glycolipids originating from either bacteria or self. This thesis investigates the role of NKT cells in autoimmune tissue-specific inflammation. We found that NKT cells can down-regulate both the central nervous …
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Synthesis of Novel Glycolipid Agonists of the Protein CD1d
… range of foreign lipids and glycolipids bound to CD1d proteins. \(\alpha\) \(\beta\)-Galactosyl Ceramide (\(\alpha\) \(\beta\)GalCer), originally isolated from a marine sponge, is a powerful agonist of CD1d capable of triggering an immune response that results in the proliferation of a range of …
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Immuno-modulatory functions of CD1d-restricted natural killer T cells
… such as recognition of glycolipids presented by CD1d, expression of NK receptors and rapid production of large amounts of cytokines, such as IL-4 and IFN-gamma,?upon activation. This early and robust cytokine burst is believed to give NKT cells the capacity to act as a link between innate and …
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Autoimmune Responses to Atherosclerotic Lipids: A Study In Murine Models of Atherosclerosis and Obesity
… molecule, namely cluster of differentiation 1d (CD1d), may impact atherosclerosis. Structurally, CD1d acts as a nonpolymorphic cell-surface receptor, resembling the major histocompatibility complex-I (MHC-I). While MHC-I restricts peptide antigen presentation to T cells, CD1d presents lipid …
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Identification of rat NKT cells and molecular analysis of their surface receptor mediated activation
… und Maus exprimieren die meisten NKT Zellen CD1d restringierte TZR mit charakteristischen Genumlagerungen- Va24JaQ/Vb11 im Menschen und Va14Ja18/Vb8.2 in der Maus. Den NKT Zellen werden außerdem wichtige Funktionen in der „first line defence“ und der Immunregulation zugesprochen. Gegenstand …
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Uncovering Novel Mechanism of Immune Modulation of Invariant Natural Killer T Cells By Liposomal Α-Galactosylceramide
… antigens via the MHC-class-I like molecule, CD1d. A synthetically derived glycolipid from the marine sponge, <em>Agelas mauritianus</em>, alpha-Galactosylceramide (α-GalCer) potently activates iNK-T cells. Within a few hours after activation, iNK-T cells produce high quantities of …
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Structure-Activity Studies of Glycosphingolipids as Antigens of Natural Killer T Cells
… to these lymphocytes. This event is mediated by CD1d, a major histocompatibility complex-like protein expressed on the surface of APCs, which binds GSL antigens by the ceramide moiety and presents the polar group to the T cell receptors of CD1d-restricted cells. The subsequent immune response …
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Protective Immunity in Atherosclerosis
… critical in activation of CD4+ T cells whereas CD1d antigen presentation is required for activation of NKT cells. The role of MHC class II antigen presentation in atherosclerosis is complex and was unexpectedly found to be associated with reduced atherosclerosis development, whereas, neointima …
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Novel Immunotherapies and Immunoregulation in a Chronic Inflammatory Disease of the Central Nervous System
… was to evaluate the immunoregulatory role of CD1d-restricted T cells by using CD1d deficient mice. Our results suggest a regulatory role of CD1d-restricted T cells in EAE. This regulation functions through limiting the autoreactive T cell cytokine responses and enhancing TGF-beta1 production …
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The Role of NKT Cells in Immune Evasion of Liver Metastases Arising from Intraocular Tumors
… from intraocular melanomas. NKT cell-deficient CD1d-/- mice and WT C57BL/6 mice treated with anti-CD1d antibody developed significantly fewer liver metastases than WT mice following either intraocular or intrasplenic injection of B16LS9 melanoma cells. The increased number of metastases in WT …
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Lipid antigens and immunoregulatory iNKT cells in the prevention and treatment of type 1 diabetes and related autoimmune diseases
… of autoimmune diseases. The glycoprotein CD1d plays an integral part in the recognition and presentation of lipid antigens such as α-galactosylceramide (α-GalCer) to iNKT cells, producing a variety of anti-inflammatory (T\(_H\)2) cytokines, such as interleukin-4 (IL-4), and …
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Cord Blood-Derived Invariant Natural Killer T Cells as a Platform for Allogeneic Chimeric Antigen Receptor Cell Therapy
… as they are restricted to the monomorphic CD1d protein in contrast to HLA restricted αβ-T cells and therefore are safe in the allogeneic setting. Furthermore, iNKT cells possess inherent antitumor mechanisms including the expression of NK activating receptors and the capability to lyse M2 …
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Protein-sphingolipid interactions and their role in immunity and disease
… in sphingolipid metabolism. Lipid loading onto CD1d is facilitated by the lysosomal lipid transfer protein Saposin B, but the lipid loading mechanism is unknown. I used a range of highly sensitive biochemical assays to probe the interaction between CD1d and SapB. Interestingly, no direct …
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Natural killer T cell subsets and regulation of autoimmune diabetes
… the contents of the antigen presenting molecule CD1d. NKT cells have a surface phenotype reminiscent of memory cells, and have been shown to rapidly produce large amounts of cytokines, such as IL-4 and IFN-gamma, upon activation. Because of their rapid response to activation, NKT cells have been …
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Immunbiologie hepatischer Natürlicher - Killer T- (NKT-) Zellen
… wurden. Die Interaktion von NKT - Zellen und CD1d exprimierenden LSEC führte zu einer Hochregulation verschiedener Adhäsions- (CD54, CD106) und kostimulatorischer (CD40, CD154, ICOS-L) Moleküle auf beiden Zelltypen. Des Weiteren zeigte sich, dass das ICOS/ICOS-L Interaktion für die …
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Investigating The Role of Il-10 Producing Nkt Cells In Prevention of Graft Versus Host Disease
… glycolipid antigens presented in the context of CD1d. Upon activation, they secrete cytokines according to the functional subtypes NKT1, NKT2, NKT10, and NKT17. The distinct cytokines released by each subtype modulate the response by conventional T cells, and thus affect GVHD outcome. Because …
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A study of invariant NKT cell biology in health and disease
… these functional differences were modified by CD1d affinity and the nature of the antigen presenting cell, co existent cytokines and donor phenotype. Lastly, we applied our iNKT investigative tools to a clinical disease where the link between iNKT cells and B cell help for antibody production …
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INKT CELLS CONTRIBUTE TO COLORECTAL CANCER PROGRESSION INDUCING NEUTROPHILS PRO-TUMORIGENIC FUNCTIONS
… Killer T (iNKT) cells are a lipid-specific, CD1d-restricted population of unconventional T cells residing also in the intestinal mucosa. Although their role in inflammation, infection and in tumor immune surveillance has been extensively elucidated, iNKT cells involvement in CRC progression …
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Ehrlichiosis: Understanding immune mechanisms that lead to the development of fatal disease
… in NKT cells, I investigated the role of CD1d-restricted NKT cells in induction of toxic shock-like syndrome. Absence of NKT cells restored the absolute numbers of CD4+ and CD8+ T cells and CD11b+ cells in the spleen, decreased expression of Fas on splenic CD4+ lymphocytes and granzyme B …
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Antigen Trafficking within <em>Chlamydia trachomatis</em>-Infected Polarized Human Endometrial Epithelial Cells.
… lipopolysaccharide (LPS) was co-localized with CD1d, a lipid antigen-presenting molecule. Collectively, these studies (i) establish a novel escape mechanism for chlamydial antigens, (ii) identify cHsp60-2 as a marker of iron stress response in <em>C. trachomatis</em>, and (iii) define for the …
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