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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 78 for “"CD19"”.

  1. Efficacy of Dual Cd19-Cd79B Car In B-Cell Malignancies

    Cheng, Xiaoyun, https://orcid.org/ <p><strong>0000-0002-0115-711X</strong></p>2023

    … with B-cell malignancies relapse following CD19-targeting chimeric antigen receptor (CAR) T cell therapy. CD19 loss is a major cause of relapse and resistance after CD19 CAR T therapy. Dual antigen targeting could overcome resistance due to antigen escape and improve outcomes after CAR T …

    uthsc Repository record

  2. Targeting the CD19/CD21 complex on B cells in the mixed lymphocyte reaction

    Broc, SabineUniversity of Westminster2022

    … by the B Cell Receptor (BCR) response regulator CD19/CD21 complex. This duality in B cells raises a particular interest in the case of acute graft-versus-host disease (GvHD), a common complication post allogeneic haematopoietic stem cell transplantation (HSCT). In this context, B cells may act …

    westminster Repository record

  3. Chimeric ANTI-CD19 Monoclonal Antibodies for the Treatment of Precursor B Cell Acute Lymphoblastic Leukemia

    Tsai, Lydia Kar-Yuk2010

    … is often lost following anti-CD20 immunotherapy. CD19 is a pan B cell membrane antigen that is restricted to the B cell lineage and expressed on B cell lymphomas and pre-B ALLs. Previous studies have shown that a murine anti-human CD19 MAb, HD37, has efficacy in SCID mice with human B cell tumors. …

    utswmed Repository record

  4. Tethered Il-15 to Augment The Therapeutic Potential of T Cells Expressing Chimeric Antigen Receptor: Maintaining Memory Potential, Persistence, and Antitumor Activity

    Hurton, Lenka2015

    … immunotherapy can retarget T cells to CD19, a tumor-associated antigen (TAA) expressed on B-cell malignancies, by the expression of a chimeric antigen receptor (CAR). Infusion of CAR-modified T cells for the treatment B-cell malignancies has demonstrated promise in preclinical and …

    uthsc Repository record

  5. Caffeine Supplementation and Moderate Intensity Exercise Modulates the Cytotoxic Lymphocyte Subset (CD+8) in NaIve and Tolerant Individuals

    Fedor, Elizabeth Ann

    … CD4=helper T cells, CD8=cytotoxic T cells, CD19=B cells). Blood was analyzed using flow cytometry. We found that cytotoxic T cells showed significant increases following the caffeinated run in both groups combined (tolerant and naïve, p=0.001) and specifically in the naïve group on the …

    wku-diss Repository record

  6. T-Cell Treatments For Solid and Hematological Tumors

    Deniger, Drew C2013

    … specific aim focused on generating bi-specific CD19-specific CAR<sup>+</sup> gamma/delta T cells with polyclonal TCRgamma/delta repertoire on CD19<sup>+</sup> artificial antigen presenting cells (aAPC). Enhanced cytolysis of CD19<sup>+</sup> leukemia was observed by CAR<sup>+</sup> gamma/delta T …

    uthsc Repository record

  7. B-Lymphozytenpopulationen des peripheren Blutes in Autoimmunität und Gesundheit

    Wehr, Claudia

    … und charakterisiert: Naive B-Zellen (CD19+, CD21+, CD27-) unterschieden sich bei Patienten mit Autoimmunkrankheiten weder in der Häufigkeit noch im Phänotyp von gesunden Kontrollpersonen. Bei SLE-Patienten waren die IgM-Gedächtnis-B-Zellen (CD19+, CD21+, CD27+) prozentual vermindert, …

    freiburg-diss Repository record

  8. Functions of Novel Ligand-independent Flt3 Alleles and RANKL in Promoting Dissemination of Murine B-Cell Leukemias to the Central Nervous System

    Papp, Eniko2014

    … by PAX5 upon B-cell commitment, co-incident with Cd19 expression. In support of this idea, we report evidence of Flt3 amplification in a rare subset of CD19- progenitors, and we show that CD19- FLT3+ cells from leukemic TM mice contain leukemia-initiating cells. Finally, we compared gene …

    toronto-retro Repository record

  9. Evaluierung des Antibody Directed Enzyme Prodrug Therapy-Konzepts im Mammakarzinom- und Lymphom-Mausmodell

    Zientkowska, Marta2012

    … Es wurden die Antikörper anti-uPAR und anti-CD19 für den Transport von β-D-Galaktosidase an den Tumor verwendet. Um die ADEPT zu evaluieren wurden die nichtinvasiven Methoden fpVCT und eXplore Optix angewendet. Anti-uPAR*β-D-Galaktosidase bindet sowohl in vitro als auch in vivo an …

    goettingen Repository record

  10. pNT22 - ein Hitzeschockprotein der 70 kDa-Familie: Analysen zur Oberflächenexpression auf Zellen des peripheren Blutes bei gesunden Probanden und Patienten des rheumatischen Formenkreises

    Benoit, Sandrine

    … wurden zusätzlich käufliche Antikörper gegen CD19, CD3, CD4, CD8 und CD14 eingesetzt. <br> <br>Insgesamt wurden Proben eines Kollektivs von 27 gesunden Spendern, 15 an Rheumatoider Arthritis (RA) erkrankter Patienten und 10 an Morbus Wegener erkrankter Patienten im Fluoreszenzcytometer …

    freiburg-diss Repository record

  11. The dynamics of anti-tumour responses generated by chimeric antigen receptor-modified immune effector cells

    Chaudhry, KajalUNSW, Sydney2018

    … antigen receptor T (CART) cells targeting the CD19 antigen, some patients have not responded well, particularly those with solid tumours. Understanding the biology of CART cell effector function may explain treatment failure, and lead to more effective cell therapy products. Population-based …

    unsw Repository record

  12. Gestörte Expression von CD70 und CD86 auf naiven CD27-B-Lymphozyten von Patienten mit Variablem Immundefektsyndrom (CVID)

    Groth, Christoph

    … klassengewechselten Gedächtnis- B- Lymphozyten (CD19+CD27+IgD-IgM-IgG+ oder IgA+) – CVID TypI. In früheren Untersuchungen konnte in unserer Arbeitsgruppe eine Untergruppe der CVID- Patienten identifiziert werden, die eine signifikant erniedrigte CD86 und CD137 Expression nach in vitro Stimulation …

    freiburg-diss Repository record

  13. An inducible, conditional and targeted B cell ablation mouse model for studying B cell functionality in the pathogenesis of human diseases

    Peng, XiaoTemple University. Libraries2017

    … in the pathogenesis of human diseases. CD19-Cre mice expressing the Cre-recombinase in B cell population were crossed with ihCD59 mice to generate the double positive transgenic mice (ihCD59+/-/CD19-Cre+/-). In Aim 1, I have demonstrated that hCD59 is specifically expressed in the B cell …

    temple Repository record

  14. Cellular Immune Changes in the Peripheral Blood of Subjects Chronically Infected with XMRV

    Goetz, Deborah L.S.2010

    … lymphocytes, CD45+ CD3- lymphocytes, CD45+ CD3- CD19- CD56+ NK cells and CD19+ B cells. Moreover, the NK phenotype in XMRV+ patients was altered, with 80% of XMRV+ patients having a significantly reduced CD56DIM population. Within this CD56DIM population present in XMRV+ patients, only 40% …

    unr Repository record

  15. Producción de anticuerpos monoclonales que reconozcan proteínas de membrana en células de memoria en aotus spp

    Cubides Amézquita, Jenner RodrigoUniversidad del Rosario2019

    … marcadores moleculares de células T de memoria CD19 +, CD27 + B y CD4 +, CD45RO +, solo los del clon SK3 reconocieron las células T Aotus CD4. En este trabajo, los enfoques bioinformáticos fueron usados para diseñar péptidos antigénicos que corresponden a las regiones extracelulares de las …

    rosario Repository record

  16. A Flow Cytometric Analysis of Immunocyte Populations in Peripheral Blood and Pleural Effusions of Patients with Cancer

    Bohn, Mandy L.

    … higher in the PE compared to PB. Levels of CD8+, CD19+ and CD14+ cells were not significantly different in the PE compared to the levels in the PB. CD16+CD56+ cells were lower in the PE versus PB. CD4+CD8+ cells, which represent a subset of activated T cells, were increased in the PE. Activation …

    loma-linda Repository record

  17. CD40 stimulation activates ‘post-activated’ B Cells which are hyporesponsive to B Cell receptor and toll-like receptor 9 stimulation in autoimmunity

    Weißenberg, Sarah Yasmin2021

    … co-receptor CD22 in SLE, RA and pSS peripheral CD19+ B cells were increased compared to HDs. Signaling abnormalities of SLE, RA and pSS B cells did not correlate to differences in tonic phosphorylation or baseline expression of signaling molecules (Syk, Btk, 1 …

    tu-berlin Repository record

  18. IL-25 and B cells in atherosclerosis

    Mantani, PolyxeniExperimental Cardiovascular Research Unit, Lund University2014

    … an association between high levels of CD19+CD40+ cells and a decreased risk of stroke while high levels of CD19+CD86+ B cells were associated with an increased risk. Another main focus was the investigation of the role of IL-25 in atherosclerosis. In order to tackle this, the cytokine …

    lund Repository record

  19. Effects of a Simulated Tennis Match on Lymphocyte Subset Measurements

    Kell, Holly

    … that were tested, which were CD4, CD8, CD19, CD95, and CX3CR1. Whole blood was added to red blood cell lysis buffer and fixation buffer, and the blood solution was incubated with antibodies specific to cell phenotype. The main results of this study indicated that there was a decrease in …

    wku-diss Repository record

  20. Investigating Tumour-Immune Cell Interactions in Paediatric Malignancies

    Masih, KatherineUniversity of Cambridge2023

    … acute lymphoblastic leukaemia treated with CD19 CAR T-cells. To investigate the TME we utilised bulk RNA-seq from patient medulloblastomas and performed highly multiplexed immune focused imaging of paediatric neuroblastoma. We discovered a distinctive methylation pattern and associated …

    cambridge Repository record

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