Global ETD Search
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Showing 1 to 20 of 25 for “"CD18"”.
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The relevance of CD11b and CD18 in the pathogenesis and treatment of psoriasis
Contains fulltext : mmubn000001_253402859.pdf (Publisher’s version ) (Open Access)
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Monocyte adherence to fibronectin: role of CD11/CD18 integrins and relationship to other monocyte functions
… fibronectin was substantially mediated by CD11/CD18 integrins, via both RGD-dependent and RGD-independent mechanisms. These data indicate that signals arising from foci of pulmonary inflammation are likely determinants of the accumulation of monocytes in the lungs of patients with chronic …
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Characterization of equine neutrophil surface antigens with an anti-β-integrin-like and two anti-CD18 monoclonal antibodies and effect of lipopolysaccharide stimulation
The surface presentations of CD18 and β-integrin-like neutrophil antigens were evaluated in six clinically normal horses twice at seven to 30 day intervals. The monoclonal antibodies (MAb) 60.3 and #38 recognize portions of CD18, the β₂-subunit of heterodimeric integrins LFA-1 (i.e. CD11a/CD18), …
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Expression of leukocyte-endothelial adhesion molecules during acute inflammation in the lung
… PMN adhesion to inflamed endothelium while CD11/CD18 is required for PMN emigration into extravascular tissues. An inducible endothelial ligand for CD18 is intercellular adhesion molecule-1 (ICAM-1). In the pulmonary circulation, PMNs emigrate by either a CD 18-independent or CD 18-dependent …
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Ingénierie génétique d'une β2-intégrine LFA-1 bovine résistante à la leucotoxine de Mannheimia haemolytica
… ruminant LFA-1, (ii) the EGF-3 module within the CD18 controls the susceptibility of any given CD18 to LKT and (iii) a non cleavable signal peptide conjugated to a LKT susceptible EGF-3-containing CD18 exacerbates LKT pronecrotic effects.
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[Beta]-amyloid-mediated nitric oxide release from rat microglia by ligation of the integrin Mac-1
… antibodies against each subunit of Mac-1 (anti-CD18 and anti-CD11b) and (2) competitive binding assay of fluorochrome-labeled [beta]25-35 with anti-CD18 or anti-CD11b by fluorescent flow cytometry. The results demonstrate that binding of CD18 and CD11b on microglial cells are individually …
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Differential expression of beta 2 integrins in Korean Behcet’s disease patients
Background and objectives: Beta 2 integrins (CD11/CD18) are cell adhesion molecules that play a major role in cell migration to inflammatory sites. They also induce cellular signaling, subsequently leading to cytokine production. On our preliminary strudy, we demonstrated possible alteration in …
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Charakterisierung der funktionalen Rolle von Cytohesin-1 in der LFA-1-vermittelten T-Zell-Adhäsion
… Interaktion mit der cytoplasmatischen Domäne von CD18 konnte in vitro dokumentiert werden. Im Rahmen dieser Arbeit gelang es zunächst, die Assoziation von Cytohesin-1 und LFA-1 auch endogen, im intakten Zellverband, mittels Kolokalisationsstudien in der lymphoblastoiden B-Zellinie LCL-721, zu …
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Study of Physiologic and Immunologic Incompatibilities of Pig to Human Transplantation
… Kupffer cells, leading to identification of CD18, beta-2 integrin, as a potential target for modification. When disruption of CD18 was accomplished, human platelet binding and clearance by pig Kupffer cells was inhibited. Further, human and pig platelet surface carbohydrates were examined …
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Corneal Wound Healing: Cells and Molecules
… if platelet extravasation was dependent on CD18 expression levels, two groups of mutant mice were studied, one with intermediate-high CD18 expression (CD18hypo (I-H)) and one with low-intermediate CD18 expression (CD18hypo (L-I)). To evaluate inflammation, excised corneas were immunolabelled …
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Integrin Modulating Factor 1 (IMF-1): A lipid that modulates leukocyte integrins
… α<sub>M</sub>β<sub>2</sub>, Mac-1, Mo1, or CD11b/CD18) that functions in several cell-cell and cell-substratum adhesion events. The capacity of CR3 to mediate adhesion may be rapidly and reversibly enhanced without changes in the number of receptors expressed on the cell surface. This thesis …
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Molecular events governing hematopoietic stem cell recruitment in Vivo in murine liver following Ischemia-reperfusion injury
… CD49d on HSCs or VCAM-1 in vivo. Blockade of HSC CD18, CD31 or CD44 did not alter adhesion. HSC adhesion in sham treated CD31-/- animals was raised compared to wild-type animals and IR injury did not further raise this adhesion. Studies in vitro demonstrated that HSC treatment with inflammatory …
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Differenzierungsabhängige Modulation der Zytokin- und Chemokinexpression bei humanen myeloischen Zell-Linien
… (CD7, CD11b, CD11c, CD13, CD14, CD15, CD18, CD19, CD33, CD34, CD38, CD40, CD41, CD42b, CD45, CD45RA, CD45RO, CD61, CD69, CD71, CD95, CD154, Glykophorin A, HLA-DR), der Zytochemie (Myeloperoxidase, Lysozym, unspezifische Esterase) und der Zellmorphologie untersucht. Es zeigte sich, daß …
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Binding of Mycobacterium tuberculosis to complement receptor type 3 expressed in mammalian cells : dependence on serum opsonins
… as it is inhibited by anti-CDllb and anti-CD18 MAbs; interestingly, binding is not inhibited by a MAb (2LPM19c) specific for the C3bi-binding site on CDI lb. Electron micrographs of infected CR3-expressing CHO cells reveal the presence of intracellular bacteria enclosed in well-defined, …
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Caracterização de células-tronco mesenquimais de camundongos normais e do modelo murino de MPS I
… CD44 e CD49e, e eram negativas para CD11b, CD13, CD18, CD19, CD31, CD45, CD49d e Gr-1 Este perfil de moléculas de superfície assemelha-se àquele descrito para a MSC humana, e indica ausência de contaminantes hematopoiéticos. Uma verificação preliminar da freqüência da MSC na medula óssea de …
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Understanding the Effect of BVDV on Innate Immune Response of Neutrophils
… TGAC and TGAN reduced the expression of CD18 and Lselectin while increasing CD14 expression. All ncp BVDV strains used enhanced neutrophil migration while the cp BVDV strain reduced neutrophil migration as compared to mock-infected control treatment. Among the BVDV strains used in current …
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Investigating pulmonary vascular B cells
… vascular B cells regulate neutrophils via CD18-mediated interactions, labelling them MHCII+AnnexinV+, and that in the absence of B cells, the lung will develop pathological fibrotic interstitial lung disease. In this body of work, we determined that pulmonary intravascular B cells can …
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A novel approach to the clinical diagnosis and treatment of canine histiocytic sarcoma
… was continued with CD204 and Iba-1 compared to CD18 which is what is currently being used by most pathologists. The IHC stains were performed on 20 tissue samples from dogs previously diagnosed with HS and other soft tissue sarcomas. The results showed that there was only a significant …
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Funktionelle Charakterisierung der Signaltransduktionskaskade des LFA-1-Integrins
… zytoplasmatischen Domäne der Integrin β2-Kette (CD18-Untereinheit) zur Erhöhung der intrazellulären Calciumkonzentration, zur IL-2-Promotoraktivierung sowie zum Anstiegs des Phosphotyrosingehalts zellulärer Proteine führte. Die Modulation dieser charakteristischen T-Zell- Aktivierungsparameter …
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