Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 24 for “"CD163"”.
-
Zelluläre Regulation und klinische Aspekte des monocyten-/macrophagenspezifischen Proteins CD163
… macrophagenspezifischen Oberflächenproteins CD163 untersucht und klinische Aspekte der löslichen Form des CD163 (sCD163) diskutiert. sCD163 wird in vivo durch einen inflammatorischen Reiz von der Zelloberfläche abgespalten. Bislang waren jedoch noch keine Mediatoren charakterisiert worden, …
-
The impact of Wnt5a signaling and tumor associated macrophages in breast cancer
… in both breast cancer and sepsis patients. The CD163 marker has been reported to recognize M2 macrophages, while CD68, on the other hand, is a frequently used pan-macrophage marker that recognizes both pro-inflammatory M1 macrophages and anti-inflammatory M2 macrophages. We evaluated CD163 as a …
-
Immune Infiltrates in Breast Cancer: Clinical Significance from Histopathology to Prognosis
… and both FOXP3+ (T-regulatory cells) and CD163+ (M2 macrophages) TILs being associated with worse outcomes. However, there is considerable heterogeneity in the prognostic literature of FOXP3+ and CD163+ TILs, with studies conflicting on both the direction and statistical significance of …
-
Pharmakokinetische und molekularpharmakodynamische Aspekte inhalativ angewandter Glucocorticoide
… wurde am Beispiel des Glucocorticoid-regulierten CD163 in humanen Monocyten verfolgt. Es wurde eine Methode adaptiert, die schließlich eine Quantifizierung der CD163-mRNA mittels Real-time-PCR ermöglichte. Es zeigte sich, dass die Anzahl der neu gebildeten mRNA-Kopien direkt von der …
-
Macrophage Polarization (M1/M2) and its Role in Wnt5a Secretion/Expression in Atherosclerosis
… analysis using Wnt5a, CD68 (for macrophages) and CD163 (for M2 macrophages) in human atherosclerotic tissue sections derived from the carotid arteries of patients undergoing endarterectomy. We also performed immuno-fluorescence analysis to detect Wnt5a in human peripheral blood differentiated M1 …
-
Clinical Relevance of the Immune Contexture and AXL Kinase in Triple-Negative Breast Cancer
… CD8+, CD103+, and FOXP3+ lymphocytes, CD68+ and CD163+ macrophages, and the expression of the immune checkpoints PD-1 and LAG-3 were assessed by immunohistochemistry. Furthermore, to understand the biological and clinical relevance of the interaction between TNBC cells and innate immune cells, we …
-
Immune Landscape of early liver metastatic lesions in a Novel Immunocompetent Murine Colorectal Cancer Metastasis Model
… and eradication of macrophages expressing CD163+ after four weeks of treatment. However, anti-CSF1R treatment did not exhibit efficacy in treating macro-metastases. Spatial transcriptomic analysis, along with multiplex immunofluorescent analysis, demonstrated the effectiveness of anti-CSF1R …
-
Targeting MERTK on tumour cells and macrophages: a potential intervention for sporadic and NF2-related meningioma and schwannoma tumours
… levels of MERTK, as well as macrophage markers CD163 and CD68, are highest in passage zero of schwannoma and meningioma primary cells. Drug treatment and immunocytochemistry experiments revealed that inhibition of MERTK by the small-molecule inhibitor UNC2025 reduces the number of tumour cells …
-
Development of Novel Macrophage Imaging Agents
… sialoadhesin and 1111n-DTPA-ED2 targeting CD163, of which both antigens are macrophage-restricted. All the agents described herein exhibit tracking to endogenous sialoadhesin-expressing macrophage populations with exceptionally fast blood clearance times. In a heterotopic cardiac …
-
Characterising the role of haptoglobin in experimental subarachnoid haemorrhage.
… there was an increase in CSF Hp and soluble CD163 macrophage haemoglobin scavenger receptor from baseline, concomitant with the Hb peak at the 24hr mark, with a steady and rapid taper off, in keeping with clearance of free Hb by 72hrs post-SAH. Additionally, histological assessment to examine …
-
M2 Polarization and Pro-Fibrotic Transition of Lupus Nephritis Macrophages
… However, in LN, increased infiltration of CD163⁺ M2 macrophages is associated with disease severity and fibrotic remodeling, suggesting that sustained reparative signaling may contribute to the pathology. Macrophage polarization is strongly influenced by the cytokine milieu. Canonical Th2 …
-
The Design of Three-Dimensional Multicellular Liver Models Using Detachable, Nanoscale Polyelectrolyte Multilayers
… the 12 day culture period, verified by CD32b and CD163 staining, respectively. Additionally, CYP1A1 enzyme activity increased significantly in the 3D liver models. The number of hepatocytes in the 3D liver model increased by approximately 60% on day 16 of culture compared to day 4 indicating. …
-
Non-Alcoholic Fatty Liver Disease: Investigating the Impact of Bariatric Care and the Role of Immune Function
… showed that specific liver immune cells, namely CD163, CD20 and CD45 were significantly increased in NAFLD versus controls and that immune cell counts were significantly correlated with specific bacterial taxa. In conclusion, both VLCD and RYGB have beneficial effects on metabolic and …
-
Elucidating the Role of Antigen-presenting Cells in the Immunopathogenesis of the Porcine Reproductive and Respiratory Syndrome Virus
… is restricted only to APCs that express CD163. Furthermore, we showed that PRRSV replicates more quickly in MoMΦ cell cultures than in CD163+ BMDC cultures and potentially in MoDCs. We continued to investigate PRRSV infection of APCs and discovered that in non-infected MoDCs, the cellular …
-
Interaction of the porcine reproductive and respiratory syndrome virus with the macrophage-specific lectin sialoadhesin
… of the endosome and on scavenger receptor CD163. The role of CD163 in genome release may require interaction with the viral GP2 and GP4 glycoproteins and relies on a functional CD163 SRCR domain 5. Also the cellular protease cathepsin E and an as yet unidentified trypsin-like serine …
-
Reversal of Neurodegeneration By Engineered Monocytes In Alzheimer’S Disease
… In tumor immunity, scavenger receptors such as CD163, CD204 and FcRIIb act to limit the proinflammatory responses of the myeloid stroma. We sought to repurpose this system to facilitate o-Tau internalization in AD while limiting inflammation. Unlike microglia in late stage AD, monocytes retain …
-
Development and Characterisation of an Immunocompetent Three-Dimensional Oral Mucosal Infection Model
… fully elucidated, as selected markers CD206 and CD163 did not sufficiently discriminate between THP-1 cells, PMA-derived, and VD3-derived macrophages. Newly highlighted, was the inflammatory environment of the 3DOMM at early and late stage culture. High levels of IL-6 and IL-8 production strongly …
-
New Aspects of Alveolar Adaptive Immune Responses in COPD
… including BDCA-2+, CD1a+langerin- and CD11c+CD68-CD163- DCs, was observed in the alveolar tissue. Notably, the DCs in LA interfaces and alveolar tissue differed from airway DCs by a distinct marker expression profile. The 3D analysis revealed an intricate connection between LAs and lymphatic …
-
The influence of ECM on mesenchymal stromal/stem cell activity and their interactions with monocytes/macrophages
… as CD206<sup>+</sup> MerTK<sup>-</sup> CD163<sup>-</sup> CD209<sup>-</sup>. This subpopulation displayed enhanced expression of *IL10*, IL6, and IL8. Moreover, conditioned media from these co-cultures influenced chondrocyte migration and chondrogenesis, with TGFβ1 playing a pivotal role …
-
Dendritic Cells in Normal and Inflamed Human Skin
… there also exists a large population of FXIIIA+CD163+ macrophages that are not immunostimulatory and phagocytose large particles. As in normal blood, psoriasis patient blood contained 3 non-overlapping subsets of myeloid DCs (BDCA-1+, CD16+, or BDCA-3+). In psoriatic skin the frequency and …
Page 1 of 2