Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"CD137L"”.
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Tolerizing Effects of Soluble CD137 on the CD137-CD137L Signaling Axis for Exploitation as a Therapeutic in Type 1 Diabetes
Las enfermedades autoinmunes (EAI) representan un desafío mayor y creciente para la salud global, siendo la diabetes tipo 1 (DT1) un ejemplo destacado. Estas enfermedades se caracterizan por una falla en la tolerancia inmunológica, lo que da lugar a la activación de células T patógenas que atacan a …
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Studies of human T cell costimulation: potential for the immunotherapy of cancer
… the costimulatory molecules CD80 and 4-1BBL (CD137L) and the cytokine IL-12 tumour cell lines were transduced to express these molecules individually or in combination in vitro. Using PBMC from healthy donors the effect of costimulation in response to pan-T cell stimulation with the anti-CD3 …
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Redirecting T Cells With Chimeric Antigen Receptors to Target Cd123+ Leukemia
… to co-express co-stimulatory molecules (CD86 and CD137L), a membrane bound cytokine (IL-15 fused to IL-15Rα), and the TAAs CD123 and CD19. CAR+ T cells specifically produced IFN-γ and lysed CD123+ leukemic cell lines and primary AML patient samples, but did not lyse D123neg tumor cells. The …