Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"CD127"”.
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Mutational Analysis of CD127 and Its Role in Immunological Diseases
… γ chain (CD132) and an IL-7 specific, α chain (CD127). In light of the many roles that IL-7 plays in T-cell biology, it is no surprise that CD127 expression is tightly regulated in T-cells. In this study, I explore the effects that disease specific mutations in CD127 have on CD127 expression, …
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Development Of Thymic Natural Killer Cells From Double Negative 1 Thymocyte Precursors
… has been described with selective expression of CD127 although their origin and differentiation are also poorly understood. Herein, we generated and characterized NK cells differentiating from thymic DN precursors. We enriched potential progenitors by sorting DN1: …
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Characterization of CD8 T cell responses in Mycobacterium Tuberculosis infection
… from TB and LTBI donors. Bcl-2, Ki67,CD95, CD57, CD127 and IFNγ were thus measured in each group.
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The effects of calorie restriction and aging on natural killer cells in c57bl/6 mice
… had increased expression of the immature marker CD127 and decreased expression of the mature marker DX5. We also compared NK cells from 22 mo old aged mice that were calorie restricted from either 4 months of age (young-onset CR) or 20 months of age (old-onset CR). The total number of NK cells …
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An analysis of the morphology and volcano-tectonic structure of the Central Indian Ridge between 18º and 21ºS
… High resolution TOBI sidescan sonar data (cruise CD127) and multibeam bathymetry data (Magofond 2 cruise), complemented by regional geophysical and geochemical datasets, provide an important opportunity to examine the processes controlling morphological and volcano-tectonic variations along the …
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An investigation of novel therapeutic strategies for the treatment of multiple sclerosis and autoimmunity
… change in serum IL-17a, the frequency of CD25hi CD127 Foxp3+ Tregs, nor in the secretion of IL-17a from effector T cells. Mirroring the data in vitro, no change was observed in the TSDR methylation status of Tregs isolated from these patients. Taken together, these results demonstrate the ability …
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Investigating Tumour-Immune Cell Interactions in Paediatric Malignancies
… high pre-treatment expression of PTEN, TIM-3, CD127, and markers of NK-cells and M1 macrophages and low expression of VISTA and CD40L were associated with improved overall survival. Collectively, this work provides novel insights into tumour-immune interactions across paediatric malignancies. …
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Proporción de subpoblaciones linfoides T y B con fenotipo regulador, inflamatorio y autorreactivo en tejido gingival de pacientes con periodontitis
… distribución, T reguladoras: CD3, CD4, CD25, CD127, CD45 y FoxP3. TH17: CD3, CD4, CD25, CD161, RIL-23, CD45 y Células B: CD19, CD5, CD1d, CD3, CD45 y 7AAD. La pruebas estadistas realizadas a los resultado obtenidos fueron la prueba de normalidad Skewness/Kurtosis, t con varianzas iguales y …
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Genomic investigation of primary immunodeficiency
… CD4+ T cells and aberrant expression of PD-1 and CD127. Study of patient T cells, IVNS1ABP knockdown Jurkat cell lines, and CRISPR/Cas9-mediated IVNS1ABP knockdown in primary human T cells demonstrated that reduced IVNS1ABP leads to T cell hyperactivation. Development of Ivns1abpEM1/+ …
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Characterisation of T cell responses to proteins expressed during Human Cytomegalovirus latency
… regulatory T cells (Tregs) can be defined as CD4+CD127$^{lo}$CD25$^{hi}$, and depleting CD4+CD25$^{hi}$ cells was investigated as a means to remove the latent-specific IL-10 secreting T cells. The results showed that this had a variable effect, suggesting that HCMV-specific IL-10 secreting cells …
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CHARACTERIZATION OF THE EPIGENOMIC PROFILE SHAPING HUMAN FOXP3+ REGULATORY T CELL IDENTITY IN THE TUMOR MICROENVIRONMENT
… map the TI-Treg epigenomic profile, CD4+ CD25+ CD127- Tregs were isolated from the blood (PB), tumors, and normal adjacent tissue (NAT) of colorectal cancer (CRC) and non-small cell lung cancer (NSCLC) patients. Chromatin accessibility and different histone modifications were profiled using …
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Peripheral inflammatory and regulatory immune changes in HIV positive to HIV positive renal transplant recipients
… CD27-PE/Cy5, CD45RA-PerCP/Cy5.5, CD25-BV421, CD127- PE/CF594, and FoxP3-Alexa647. Antibody concentrations in the panel were optimised by titrating each marker on resting, or Phytohaemagglutinin (PHA) stimulated, peripheral blood mononuclear cells (PBMCs). The median fluorescent intensity (MFI) …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… despite a cell autonomous 25% decrease in IL7Ra/CD127 on their cell surface. Collectively, these results define a key role for controlling SUMO conjugation by SENP2 in the survival of naïve and memory CD8 T cells, apparently involving a pathway independent of the established TCR and IL-7 …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… despite a cell autonomous 25% decrease in IL7Ra/CD127 on their cell surface. Collectively, these results define a key role for controlling SUMO conjugation by SENP2 in the survival of naïve and memory CD8 T cells, apparently involving a pathway independent of the established TCR and IL-7 …