Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"CD117"”.
-
Stellenwert der Immunzytologie in der Diagnostik und Verlaufsbeurteilung Akuter Myeloischer Leukämien (AML) : eine retrospektive Analyse aus der Medizinischen Universitätsklinik Freiburg 1994 - 1998
… Krankheitsverläufe noch auf die Zellmarker CD34, CD117, HLA-DR, Lysozym, MFI-bcl2 und MFI-MDR. <br>Patienten bei denen die Zellmarker MPO, CD13, CD33, CD65w und CD117 alle positiv waren, wiesen im Trend eine bessere Prognose auf als die übrigen Fälle. <br>Patienten, bei denen keine IPT …
-
Her4 Promotes A Stem-Like Phenotype In Osteosarcoma
… can be identified by expression of Stro1, CD117 and embryonic stem cell transcription factors such as Sox2, Nanog and Oct3/4. Additionally, OS stem-like cells display high aldehyde dehydrogenase activity and sarcosphere formation under limited nutrient media and anchorage independence. …
-
The role of cancer stem cells in osteosarcoma
… putative CSC markers (aldehyde dehydrogenase and CD117). The intracellular enzyme aldehyde dehydrogenase (ALDH) and tyrosine kinase receptor CD117 were found to be heterogeneously expressed amongst the cell lines. All cell lines when plated at low density could recapitulate the colony hierarchies …
-
Herstellung und Validierung von Tissue Microarrays von Knochenmarkbiopsien
… CD15, CD20, CD34, CD61, CD68, CD79a , CD99, CD117, CD138, MPO, HbA1, Glycophorin and TdT. The results can be summarized as follows: The TMA technique is an adequate method for the evaluation of bone marrow biopsies. In morphological analysis of the H&E-stained TMAs 6 (4%) of the 148 cases …
-
ASSESSMENT OF RELEVANT MOLECULAR TARGETS WITH THERAPEUTIC SIGNIFICANCE IN CANINE NEOPLASMS.
… in the tumor microenvironment: FAP, EDB+FN, KIT (CD117), PDGFR-β, and OXTR. These molecules are involved in tumor progression, stromal remodeling, angiogenesis, and hormonal regulation. Results confirm that canine tumors can harbor multiple therapeutically relevant molecular targets. FAP and …
-
IDENTIFICATION OF NCAM1 AS A NOVEL PROGNOSTIC PROSTATE CANCER STEM CELL BIOMARKER
… of a cell fraction with basal traits (p63+/AR-/CD117+ cells) and a quiescent phenotype, sitting at the apex of the hierarchical structure of the NCAM1+ population. These cells were functionally characterized by Hedgehog signaling which drives NCAM1+/CD117+ -PCSC self-renewal ability. Moreover, …
-
Prognostischer Zusammenhang zwischen Mutationen des KIT- und PDGFRA-Gens und molekularzytogenetischen Veränderungen gastrointestinaler Stromatumoren
… Gastrointestinale Stromatumoren (GIST) sind CD117-positive mesenchymale Tumoren des Gastrointestinaltrakts. Mit molekularzytogenetischen Methoden konnten in der letzten Dekade einige Zusammenhänge von chromosomalen Verlusten (u.a. -14q, -1p und -22q) mit der Prognose der betroffenen Patienten …
-
Engineering functional recombinant proteins based on antibody domains and fragments of C. botulinum neurotoxin
… regions (CDR’S). The selected scFv binds to CD117 that is a membrane tyrosine kinase receptor present on the surface of various tumour cells. The variable part of chains shows great variability in amino acid sequence among the chains. The unique sequence of amino acid residues for variable …
-
Mechanism of tissue transglutaminase upregulation and its role in ovarian cancer metastasis
… self-renewing spheroids, the percentage of CD44+CD117+ ovarian cancer stem cells (CSCs) and with the expression level of stem cell specific transcriptional factors Nanog, Oct3/4, and Sox2. These data suggest that TG2 is an important player in the homeostasis of ovarian CSCs, which are critical …
-
Clinico-morphological Characteristics, Histological Typification and Their Correlation with Some Molecular Markers in Cutaneous Melanoma // Клинико-морфологични характеристики, хистотипизация и корелацията им с някои молекулярни маркери при кожен меланом
… съпоставихме експресията на маркерите анти-CD117 антитяло и анти-VEGF антитяло с дебелината на лезията в милиметри по скалата на Breslow с цел установяване на зависимост, която да обуслови прогресията на лезията. На базата на проведеното от нас изследване изработихме диагностичен алгоритъм …
-
KIT Mutations in Australian Canine Mast Cell Tumours and Correlations with Patient Prognostic Factors
… with the mutational evaluation of the CD117 Proto-Oncogene Receptor Tyrosine Kinase gene, KIT. Dogs with MCTs harbouring an internal tandem duplication (ITD) within exon 11 of the extracellular regulatory domain of KIT are more likely to respond to treatment with tyrosine kinase …
-
SVILUPPO DI TECNICHE PER L'ISOLAMENTO, LA CARATTERIZZAZIONE E IL DIFFERENZIAMENTO DI CELLULE STAMINALI MESENCHIMALI PER UN USO IN MEDICINA RIGENERATIVA
… CD31, CD34 and CD45 negative, CD73, CD90, CD105, CD117, CD271, and Stro-1 positive), and can give rise to the same cell lineages, such as osteocytes, chondrocytes and adipocytes cells. The different methods to isolate the hMSCs and the hASCs from human biopsies have been valuated and improved. …
-
Expression von Zytokinrezeptoren, Adhäsionsmolekülen und kostimulatorischen Molekülen und deren klinische Relevanz bei der akuten myeloischen Leukämie
… Hämopoese exprimiert werden, wie der SCF-R (CD117), FL-R (CD135), IL-3-R (CD123) und zum andern Zytokinrezeptoren, die erst in späteren Differenzierungsstadien der monozytären Zelllinie (v.a. GM-CSF-R; CD116) und der granulozytären Zelllinie (v.a. G-CSF-R, CD114) exprimiert werden. Die …
-
Immunhistochemischer Algorithmus zur Diagnostik maligner Keimzelltumoren des Hodens
Maligne Keimzelltumoren des Hodens sind die häufigsten soliden malignen Tumoren des jungen Mannes und werden in Seminome und Nicht-Seminome unterteilt. Histopathologisch können Nicht-Seminome in embryonale Karzinome, Dottersacktumoren, Chorionkarzinome und Teratome unterschieden werden. Die exakte …