Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"CD107a"”.
-
Natural Killer Cell Responses in Chronic Hepatitis C Virus Infection
… by the frequency of NK or T cells expressing CD107a, a marker of cellular degranulation. Variance between responses in HCV-infected versus healthy donors and variance between NK versus T cell responses were analyzed by matched two-way ANOVA with multiple comparisons and Bonferroni post-test …
-
Role of Macrophage Subsets in CD8+ T Cell Dysfunction in Chronic HCV Infection
… significantly increased the percentage of CD107a+ and IFN-γ+ CD8+T cells in a contact-dependent manner. Similar autologous co-cultures between M1 and CD8+T cells from patients with chronic HCV infection showed that M1 significantly reduced the percentage of IFN-γ+ CD8+T cells, even though …
-
Activation of MAIT cells by antigen presenting cells: a comprehensive analysis and assessment of HIV and TB disease on these interactions
… TB had a lower capacity to degranulate (express CD107a) and produce IFN-γ compared to HC. HIV-infection alone did not affect these functions. The levels of soluble IFN-α2 were reduced in the groups with HIV only and active TB only while IFN-γ was reduced in all patient groups. Blocking …
-
Humanized mice to test vaccination against influenza virus via dendritic cells.
… T cells produced IFN-γ and expressed surface CD107a consistent with the acquisition of effector function. Finally, upon vaccination with anti-DC receptor (DCIR)-FluM1 fusion protein and poly I:C as an adjuvant, DCs efficiently cross-presented FluM1 and expanded antigen-specific CD8⁺T cells. …
-
Novel approaches to enhance the protective immune responses of vaccines against Porcine Reproductive and Respiratory Syndrome Virus
… by increased IFN-γ secretion and/or enhanced CD107a expression. The results offer a novel strategy to incorporate cytokine genes into PRRSV genome as potent bio-active adjuvants expressed by the vaccine virus itself. Since we showed that PRRSV VR2385 down-regulated swine leukocyte antigen …
-
Dynamic Assessment of Nk Cell Interactions With Pediatric Tumor Cells to Predict Response to Immunotherapy
… subpopulations showed increased degranulation (CD107a) and IFNγ secretion in response to tumor cell encounter.</p> <p>I also demonstrate that IFNγ has a variable impact on NK-mediated lysis of pediatric tumor cell lines, with some cell lines becoming more resistant to NK cells and others …
-
Regulation of T cell effector functions in the intestinal mucosa
… to differentiate into two distinct subsets, CD107a/b+ cytotoxic T cells (CTLs) and FoxP3+CD8+ T cells. FoxP3+CD8+ T cells but not CTLs required chemokine receptor 9 (CCR9) for effective homing to and expansion within the small intestinal mucosa. Further, we found that IRF8, but not IRF4, …
-
Selbsttoleranz von NK-Zellen
In den letzten Jahren wurden im murinen Modell NK-Zellen detektiert, welche keinen bekannten HLA-spezifischen inhibitorischen Rezeptor exprimieren. Diese Entdeckungen widersprechen dem bisher gültigen at-least-one -Modell, nach dem die Selbsttoleranz durch mindestens einen inhibitorischen Rezeptor …