Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"CD103"”.
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Respiratory infection with the paramyxovirus SV5 results in maturation and cytokine secretion in CD103- and CD103+ dendritic cell subsets.
… four subsets based on the expression of CD8 and CD103 molecules. Among the four subsets, the two CD103+ DC subsets are from the airway while the CD8+ CD103- DC are lymph node resident. xi The CD8- CD103- DC subset is a mixed population, including CD103- CD11b+ lung parenchyma DC, CD8- lymph node …
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Phenotype and function of intestinal CD103+ dendritic cells
… these antigens to T cells. Recently, intestinal CD103+ DCs have been shown to promote induction of both gut homing receptors on responding T cells and differentiation of FoxP3+ regulatory T cells via the vitamin A metabolite retinoic acid (RA). Another intestinal DC/macrophage subset, expressing …
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The ontogeny and function of intestinal dendritic cells
… cDC subsets. At the start of the thesis work, CD103+ DCs had been identified in the intestinal lamina propria (LP) that were found to have an enhanced capacity to induce gut-homing receptors and generate FoxP3+ Tregs in vitro. Separate studies had identified a major subset of CX3CR1+ …
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Tumour infiltrating T cells in non-small cell lung cancer and their interactions with cancer-associated fibroblasts
… co-express the tissue resident memory marker CD103 and display an exhausted tissue resident memory T cell phenotype that shows cytotoxicity against neoplastic cells. CD39 acts in concert with CD73 to generate adenosine and thereby promote immunosuppression in the TME. Previous work from our …
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TREM-2 and Dendritic Cells in the Pathogenesis of Allergic Airway Inflammation
… subsets based on the expression of CD11b and CD103. Both subsets have been shown to drive pro- or anti-inflammatory responses based on stimulus and cytokine environment.|Dendritic cells express several pattern recognition receptors (PRRs) that are critical for their function as sentinels of …
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Regulation of Intestinal Epithelial Thymic Stromal Lymphopoietin Gene Expression by Retinoic Acid Receptor Alpha
… cells. We have previously described decreased CD103+ DCs numbers in the intestinal compartments of RARα-deficient mice (RARαvillin mice). We sought to generate an experimental system to identify signaling pathway(s) or mechanism(s) that might be governing these effects, specifically RA …
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Understanding the Role of Dendritic Cell Subsets in the Generation of a CD8+ T Cell Response Following Pulmonary Vaccinia Viral Infection
… DC subsets are present within the lung tissue (CD103+ DC and CD11b+ DC) and draining lymph nodes (MLN) (CD8α+), and as such, all are potential regulators of T cell activation (for review see1,2). These studies sought to understand how DC subsets contribute to the generation of virus-specific …
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Clinical Relevance of the Immune Contexture and AXL Kinase in Triple-Negative Breast Cancer
… sections. The density of CD4+, CD8+, CD103+, and FOXP3+ lymphocytes, CD68+ and CD163+ macrophages, and the expression of the immune checkpoints PD-1 and LAG-3 were assessed by immunohistochemistry. Furthermore, to understand the biological and clinical relevance of the interaction …
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Enhancing Chimeric Antigen Receptor T cell therapy in Mouse EGFRvIII Heterogeneous Glioblastoma
… dendritic cells (cDCs) as well as the CD103+XCR1+ population known for migration and antigen cross-presentation. Treatment with IL7 or IL7 Flt3L CAR T cells improved overall survival to 67% and 50%, respectively, compared to 9% in vCAR and vFL and no survivors in PBS treated. However, …
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Hypoxia Acts As An Environmental Cue For The Human Tissue-Resident Memory T-Cell Differentiation Program
… by a greater than five-fold increase in CD69+CD103+ cells expressing human T<sub>RM</sub> hallmarks and enrichment for endogenous human T<sub>RM</sub> gene signatures, including increased expression of adhesion molecules and decreased expression of genes involved in recirculation. Hypoxia and …
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Using Mice with Conditional Deletion of the IFNg Receptor to Identify the Cellular Targets of IFNg during Development of Anti-Listeria Immune Responses
… in dendritic cells expressing CD8a and/or CD103 displayed increased susceptibility to Listeria infection. This phenotype was traced back to a defect in the capacity of IFNg unresponsive CD8a+ DCs to produce IL-12. The IFNg required for priming CD8a+ DCs for optimal IL-12 production is …
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Defining the role of the transcription factor T-bet in the innate immune system in intestinal inflammation.
… produced by CD11chigh class II+ CD11b+ CD103- dendritic cells (DCs), synergised with IL-23 to drive IL-17A production by ILCs. <br/>Helicobacter typhlonius (HT) was identified as the key colitigenic bacterium driving TRUC disease. Four-five-four ribosomal RNA gene sequencing demonstrated …
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Development Of Thymic Natural Killer Cells From Double Negative 1 Thymocyte Precursors
… as both expressed novel markers such as CD25 and CD103, which were not expressed by splenic NK cells. Finally, we found that <italic>in vitro</italic> cells generated from thymic precursors secreted cytokines when stimulated and degranulated upon target exposure, indicating that they were …
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Investigating the T cell-specific role of Interleukin-4 receptor alpha (IL-4Rα) in tuberculosis (TB)
… ) expressed reduced amounts of CXCR3, CD69, and CD103, which are all markers associated with poorer migration into the lung parenchyma. Importantly, these factors result in decreased survival in T cell-specific IL-4Rα mice. In conclusion this study demonstrates that absence of IL-4Rα on T cells …
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Batf3-Deficient Mice: Susceptibility to Toxoplasma gondii and Responses to IL-12 Treatment in vivo
… DCs and related peripheral CD103<super>+</super> DCs. Batf3<super>-/-</super> mice were extremely susceptible to <italic>T. gondii</italic> infection, with defective priming of CD8<super>+</super> T cells, and decreased production of IL-12 and IFNγ. IL-12 administration …
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The Role and Regulation of Id2 In Dendritic Cells
… Id2 to modestly promote CXCL2 production from CD103<sup>+</sup> cDC1s, though Id2 was largely dispensable for their maturation. Collectively, we conclude Id2 predominately exerts its role as a developmental regulator of the cDC1 lineage, but also regulates the production of specific cytokines …
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Reprogramming the immune environment in breast cancer via dendritic cells.
… exposed DCs expand CD8⁺ T cells that express CD103, a ligand for E-cadherin. These CD8+ T cells, which produce higher IFN-γ, Granzyme A and Granzyme B, accumulate in the tumors leading to enhanced tumor necrosis in vivo. DC reprogramming by β-glucan is dependent upon dectin-1 engagement. The …