Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"CCR9"”.
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Identifikation und Charakterisierung von im Thymus exprimierten Chemokinrezeptoren
… Expressionsanalyse der Chemokinrezeptoren CCR9 und CCR11 in unterschiedlichen Geweben der Maus wurden durchgeführt. Durch die genetische Inaktivierung des Chemokinrezeptors CCR9 in der Maus und knock-in des Fluoreszenzmarkers GFP in den CCR9-Locus sollte die Funktion von CCR9 im Thymus …
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EFFECTOR T CELL HOMING TO THE SMALL INTESTINAL MUCOSA
… array of chemokine receptors including CCR9, CCR6, CCR5, CXCR6 and CXCR3. Furthermore, since CCR9 was shown to be selectively induced on CD4+ T cell activated in mesenteric lymphnodes and expressed on the majority of CD4+ T cells entering into the small intestinal LP, CCR9 was suggested …
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Non-conventional Regulation of Treg Development and Function
… patients. The role of the gut homing molecule CCR9 in IBD is poorly understood. CCR9 is a potential drug target that is currently being investigated due to the potential to disrupt migration of pathogenic T cells to the gut. However clinical trials indicate a protracted therapeutic response. …
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The role of the atypical chemokine receptor CCX-CKR in thymocyte development and its influence on the link between innate and adaptive immunity through regulation of dendritic cell migration.
… can scavenge and degrade the ligands of CCR7 and CCR9, two receptors that are crucial during instruction of T cell development in the thymus and dendritic cell migration for initiation of adaptive immune responses. Within the thymus CCL19, CCL21 and CCL25 direct CCR7- and CCR9-expressing …
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Selective HDAC6 Inhibition in Systemic Lupus Erythematosus
… and RNAseq analysis unveiled six genes (Cebpb, Ccr9, Spib, Nfil3, Lgals1, and Pou2af1) that may play a role in the aforementioned abnormalities. Overall, these findings show that HDAC6i decreased disease in NZB/W mice by targeting multiple components of the immune response, including glomerular …
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Primary sclerosing cholangitis: from genetic risk to disease biology
… blood T-cell subsets (including the rare CCR9+ gut-homing T-cells) from 80 patients with PSC and IBD. With colocalisation, I assign causal genes to five PSC risk loci, and assign other epigenetic regulatory features including methylation or histone modification, to six risk loci. …
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Regulation of T cell effector functions in the intestinal mucosa
… but not CTLs required chemokine receptor 9 (CCR9) for effective homing to and expansion within the small intestinal mucosa. Further, we found that IRF8, but not IRF4, expression by intestinal dendritic cells (DCs) was critical for the development of the FoxP3+ subset in steady state but not …
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Phenotype and function of intestinal CD103+ dendritic cells
Mucosal tissues such as the intestine present an enormous surface area to the outside environment and are continually exposed to foreign antigens in food and microflora. Thus, the intestinal mucosa must must remain tolerant to these innocuous antigens while at same time be able to mount effective …