Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"CCR7"”.
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Ligand Bias by the Endogenous Agonists of CCR7
… endogenous agonists for the chemokine receptor CCR7. They are known to be equipotent in promoting Gi/o mediated calcium mobilization, chemotaxis and inhibition of adenylyl cyclase activity. Here we test the hypothesis that these ligands are biased agonists that differentially activate the …
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Synthesis and Characterisation of Dual CCR7/CXCR4 Antagonists
… The activation of CC chemokine receptor 7 (CCR7) and C-X-C chemokine receptor type 4 (CXCR4) plays an important role in lymph node metastasis in a variety of cancers. Indeed, in patients with tumours which are positive for CCR7 and/or CXCR4 expression, prognosis and survival are poorer than …
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The Role of CCR7 and Its Ligands in a Behcet’s Disease Mouse Model
BACKGROUND: CCR7 and its ligands, CCL21 and CCL19, were known to establish microenvironment for the initiation of immune responses in secondary lymphoid tissue. It was reported that plt/plt (CCL21 and CCL19 gene-deleted) mice have defects in lymphocyte homing and DC localization. Recent studies …
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Role of N-terminal residues of CCL19 and CCL21 in binding and activation of CCR7
… and CCL21 acting on their associated receptor CCR7 are postulated to be key drivers of lymph node metastasis in a number of malignancies including breast, colon, gastric, & thyroid cancers. It has been reported that the cleavage of the pre-cysteine bridge N-terminal residues of CCL21 (SDGGAQD) …
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The role of CCR7 axis in facilitating chemoresistance, radioresistance and induction of cell proliferation in cancer
… role in human biology. Chemokine receptor CCR7, activated by its ligands CCL19 & CCL21, is known to play a significant role in cancer metastasis. In view of the wider roles that chemokines play in the biology of the cell, we hypothesised that CCR7 could influence cancer progression through …
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Characterization of Dendritic Cells in the Bovine Mammary Gland
… which they upregulate homing receptors, such as CCR7, and antigen presentation markers, including MHCII and CD80. A primary cell culture model was used to evaluate changes in transcription of CD80 and CCR7 after LPS stimulation. Cell cultures contained digested and Ficoll separated mammary tissue …
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cDNA microarray Analysis Identifies Symptom-Associated Chemokine Genes in Behcet's Disease Mouse Model
… of BD eye than BD inactive and BD skin. However, CCR7 was lower in BD skin relative to BD inactive and BD eye. The expression patterns of CCL19, a ligand of CCR7, was similar to CCR7 in lymph nodes. The expression patterns of CCL21, a ligand of CCR7, was expressed similarly among groups within the …
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Investigating the spatiotemporal dynamics of mononuclear phagocytes in solid tumours.
… DCs capture tumour antigens and upregulate CCR7, which directs their migration to secondary lymphoid organs, where they prime anti-tumour T cell activity. In this work, we aimed to resolve the spatiotemporal dynamics of MNPs following tumour infiltration and investigate how immune checkpoint …
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Lymphocyte subset variability between human lymphoid tissues
… and distinct phenotype including differences in CCR7 and BAFF-R expression. IgM-only B cells also included two populations with different phenotype and tissue-specific abundances. Single-cell RNA sequencing was used to further investigate the differentiation, functional, and dissemination …
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Perfil de expresión de miRNA´S en cáncer de próstata de inicio temprano e identificación de sus posibles genes blanco relacionados con la carcinogénesis
… lesiones tumorales de CPITe. El gen elegido fue CCR7 debido a que en el estudio de análisis de redes se encontró coexpresado con miRNAs sobre expresados exclusivos de pacientes jóvenes. CCR7 codifica para un receptor de quimiocina necesario para el tráfico y localización de diferentes células del …
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Risk-Factor Induced Changes In The Breast Microenvironment Facilitate Inflammatory Breast Cancer Progression and Lymphovascular Invasion
… between lymphatic pulsing, tumor growth and CCR7-CCL21 related tumor trafficking warrant further investigation.</p> <p>CCR7 is an immune cell receptor that mediates immune cell trafficking into lymphatics that can be expressed on tumor cells. We examined the expression of CCR7 in IBC and …
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Der Einfluss von Chemokinen auf die Migration von naiven und Effektor-CD8-T-Zellen in der Milz
… CD8 Effektorzellen den Chemokinrezeptor CCR7 herunterregulieren und deshalb im Gegensatz zu naiven T-Zellen, die eine hohe Expression von CCR7 aufweisen, nicht mehr auf einen Reiz der Chemokine SLC und ELC reagieren. Daraus ließ sich ableiten, warum CD8 Effektorzellen aus der weißen Pulpa …
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Disrupting Tymp-Mediated Pathways to Block Lymph Node Metastasis in Ovarian Cancer
… dissemination. Furthermore, we identified that CCR7 (epithelial cancer cell)-CCL19 (macrophage or dendritic cells) axis plays a key role in LN metastasis, with TYMP knockdown resulting in reduced CCR7 expression. This work provides a new understanding of the modes of ovarian cancer metastasis …
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Estudo do papel do lpg2 na migração de células dendríticas infectadas por Leishmania infantum
… microscopy. Furthermore, the expression of CCR7 in dendritic cells infected by different Leishmania strains was assessed by flow cytometry. Finally, to investigate the activation of the ERK1/2 signaling pathway, we evaluated the expression of ERK1/2 protein using the western blot technique. …
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Molecular mechanisms of T cell homing in Hodgkin's lymphoma : implications for T-cell-based therapies
… on infiltrating T cells. CXCR3, CXCR4 and CCR7 were expressed on major T cell populations with CXCR5, CXCR6, CCR4 and CCR5 on minor populations. Tumour cells expressed CXCL10, CXCL12 and CCL21. Vessels expressed ICAM-1, CXCL12, CCL17 and CCL21. Tumour cell lines secreted factors that …
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Effects of interstitial flow on tumor cell migration
… along the streamline. We provide evidence that CCR7-dependent autologous chemotaxis is the mechanism by which cells migrate with the flow, while a competing CCR7-independent mechanism leads to migration against the flow. Furthermore, we demonstrate these competing mechanisms are a powerful …
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The role of the atypical chemokine receptor CCX-CKR in thymocyte development and its influence on the link between innate and adaptive immunity through regulation of dendritic cell migration.
… that can scavenge and degrade the ligands of CCR7 and CCR9, two receptors that are crucial during instruction of T cell development in the thymus and dendritic cell migration for initiation of adaptive immune responses. Within the thymus CCL19, CCL21 and CCL25 direct CCR7- and CCR9-expressing …
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Functional Responses of Lung Dendritic Cell Subsets in Flt3 Ligand-Induced Immunomodulation in Allergic Asthma
… expression of CD8α, B220, CD19, F4/80, MHC II, CCR7, CD40, PDL1, PDL2, CD80, and CD86, were identified in the lungs of PBS-treated and OVA-sensitized and challenged mice with and without treatment with Flt3-L. Functional tests revealed that CD11chighCD11blow and CD11clowCD11bhigh dendritic cells …
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An investigation of how dendritic cell migration is modulated during Leishmania mexicana infection
… is associated with reduced surface expression of CCR7, this does not entirely account for the failure of DC migration and therapeutic targeting of DCs does not enhance protective immunity. Crucially, it is through production of cysteine protease B that L. mexicana can suppress migration of …
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Die Rolle von dendritischen Zellen und Chemokinen bei der Regulation der Immunantwort gegen Erreger der kutanen Leishmaniose
… eine Hochregulation der mRNA-Expression von CCR7 in dendritischen Zellen. Von diesem Rezeptor ist bekannt, dass er die Chemokine CCL19/MIP-3β und CCL21/6Ckine, welche im Lymphknoten konstitutiv exprimiert werden, mit großer Affinität bindet und für die zielgerichtete Migration dendritischer …
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