Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"CCR5 receptor"”.
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Sythesis and Biological Screening of a Series of Novel Chemokine Receptor CCR5 Antagonists
The chemokine receptor CCR5 has been implicated in the pathogenesis of cancers and AIDS. A series of novel piperidine derivatives were designed, synthesized, and evaluated as CCR5 antagonists. The ability of the new ligands to inhibit the increment of intracellular calcium level stimulated by …
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The role of the CCR5 co-receptor conformation in HIV fusion
This thesis aimed to better define the co-receptor conformation by determining whether mutants of the CCR5 receptor stabilized in the active conformation were less able to mediate HIV fussion. Eight mutant receptors were generated by site-directed mutagenesis and screened for constitutive activity …
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Functional consequences of South African mutations of the HIV-1 co-receptor, CCR5
Four mutations of the CCR5 receptor have been identified in the South African population, but the effects of these mutations on CCR5 function and HIV infection are unknown. We have used in vitro methods to assess the ffect of the mutations, Asp2Val, Leu107Phe, Arg225Gln and Arg225stop, on CCR5 …
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Characterisation of the Ugandan HIV epidemic with full-length genome sequence data from 1986 to 2016
… 17% in the modern PANGEA sample. Furthermore, co-receptor tropism (CXCR4 or CCR5) was predicted with geno2pheno and a significant difference between the historical subtypes was observed: 63% of subtype D genomes are X4 tropic (known to be associated with faster progression to AIDS) whilst 0% of A1 …
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Studies of G Protein-Coupled Receptor Stability and Dimerization Using Novel Fluorescence and Crosslinking Approaches
<p>G protein-coupled receptors (GPCRs) comprise a large family of related seventransmembrane- helical membrane proteins that bind to specific extracellular ligands, such as hormones or neuromodulators. The active receptor-ligand complex then engages with a heterotrimeric G protein on the …