Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"CCR2"”.
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Assessing The Outcomes of Blocking Ccl2-Ccr2 Signaling Axis On Breast Cancer Brain Metastasis
… chemokine CCL2, which enhances the chemotaxis of CCR2<sup>+</sup> myeloid cells, a major subpopulation of bone marrow-derived myeloid cells (BMDMs), from peripheral blood into the brain tumor microenvironment (TME), eventually promoting brain metastasis outgrowth by driving immune suppression. …
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The role of the inflammatory chemokine receptor CCR2 in immune responses to respiratory viral infection
… This revealed that the chemokine receptor CCR2 was highly expressed in CD8⁺ T cells in the mLN, spleen, peripheral blood, and lung parenchyma. Further investigation revealed that CCR2 was expressed within the first T cell division in the mLN, and maintained broad and high expression across …
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Participación de los receptores de quimiocinas CCR1 y CCR2 en dolor inflamatorio y neoplásico en ratones
… bloqueo de los receptores de quimiocinas CCR1 y CCR2 en el dolor inflamatorio y neoplásico experimental. El aumento local de la concentración de CCL2 en respuesta a una inflamación aguda o crónica contribuye al desarrollo de la hiperalgesia inflamatoria. Por ello, la hiperalgesia puede ser …
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Investigating the role of the CCL2/CCR2 axis in monocytes and its modulation by extracellular nucleotides
The chemokine CCL2 activates its cognate receptor CCR2 to orchestrate monocyte trafficking towards infected, inflamed, and injured tissues during immune responses and the development of inflammatory disease. However, despite research into this area being plentiful, CCR2 antagonists have lacked …
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The chemokine CCL2/CCR2 signaling mediates cancer associated fibroblasts-cancer cells interaction and promotes basal-like breast cancer progression
… and METABRIC datasets revealed that the CCL2/CCR2 pair expressed highest in the basal-like subtype. We confirmed high CCL2 expression from CAFs isolated from primary human and mouse breast cancer samples. CAFs with high CCL2 expression significantly promoted xenograft growth when co-grated …
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Pharmacological characterization of losartan as a CCR2 antagonist and pre-clinical and pharmacodynamic assessment as a potential anti-metastatic therapy
To view the abstract, please see the full text of the document.
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Implicación de las quiomicinas CCL2 CCL5 en modelos de dolor neoplásico experimental.
… del bloqueo de los receptores de quimiocinas CCR2 y CCR1 en el dolor neoplásico experimental. La administración de un antagonista de CCR2, evita la hiperalgesia térmica en ratones inoculados con células tumorales de fibrosarcoma NCTC 2472. Este efecto se produce tanto a nivel periférico como …
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Mise en évidence du rôle physiologique de la chimiokine CCL2 dans la neurotransmission nociceptive au niveau spinal
… in the immune response, we focused on the CCL2-CCR2 ability to regulate arthritic pain. We first evaluated the analgesic properties of INCB3344, a specific antagonist of the CCR2 receptor, in a model of inflammatory pain. It reverses both provoked and spontaneous pain by 50% when administered …
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Mechanism of local IL-6 production and its role in accelerating vascular inflammation leading to aortic diseases
… were produced with infusion into IL-6-/- or CCR2-/- mice over the same time period along with significantly reduced inductions of aortic IL-6 and MCP-1. Using flow cytometric quantification of aortic cellular constituents, we found that Ang II induced CCR2+ macrophage accumulation of a …
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The Role of Monocyte Chemotactic Protein-1 In the Development of Central Nervous System Fatigue In Healthy Mice and In Response to Cancer Chemotherapy
… MCP-1 pathway induced by blocking its receptor CCR2 on 5FU-induced changes in neural factors that are currently known to be associated with the development of CNS fatigue. In Specific Aim 2, mice were i.p. injected with either sPBS or 5-fluorouracil (5FU; 60mg/kg body weight/day) for five …
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Acute Pro-inflammatory Immune Response Following Different Resistance Exercise Protocols in Trained Men
… Changes in plasma TNF?, MCP-1, and expression of CCR2, CD11b, and GCR on CD14++CD16- monocytes were similar following HVY and VOL. When collapsed across groups, TNF? was significantly increased at IP, 30P, 1H and 2H post-exercise (p = 0.001 – 0.004), while MCP-1 was significantly elevated at all …
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Isolation of Therapeutic Antibodies Against Microseminoprotien to Potentially Overcome Resistance to Anti-Angiogenic Therapy
… migration studies and the Tango GPCR assay for CCR2, MSMP’s cognate receptor. Results from these <em>in vitro </em>studies suggest that inhibiting MSMP from binding to CCR2 has potential anti-cancer properties. Specifically, it could result in a reduction in cellular proliferation and tumor …
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Cytokines regulation of chemokine and chemokine receptor in relation to multiple sclerosis.
… its receptor since astrocytes did not express CCR2 on this astrocyte culture. CCR2-independent binding of CCL2 was confirmed by the absence of intracellular signalling, evidenced by the lack of calcium influx as well as of Erk and Akt phosphorylation, in CCL2-treated astrocytes. Even though …
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Les Récepteurs nicotiniques de l'acétylcholine modulent la production et la distribution des monocytes pro-inflammatoires
… du nombre de monocytes pro-inflammatoires CCR2+LytChigh (M1) induite par stimulation de la moelle osseuse ex vivo (M-CSF+IFNy) en réduisant leur prolifération et viabilité sans affecter les neutrophiles. Les sous-unités prédominantes dans la moelle osseuse sont l'α7 et l'α9, dont …
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Multi-Pronged Approach to Understanding the Toxicity Associated with CAR T-Cell Therapy
… of secreting blocking agents targeting the CCL2–CCR2 axis, the principal pathway of monocyte chemotaxis. Several approaches iv were tested, including secretion of eotaxin-3, scFvs, and a nanobody. While eotaxin-3 and anti-CCR2 scFvs showed limited efficacy, anti-CCL2 constructs were expressed and …
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The effect of testosterone on factors associated with diabetes, atherosclerosis and obesity.
… blocked androgen receptor (AR) on CX3CR1 and CCR2 and pro-inflammatory cytokines in macrophage cells and on adiponectin, PP ARB/o, PAI-1, leptin and chemokines in adipocyte cells, respectively.In the clinical studies, a reduction in adiponectin levels after 3 months was seen in the short-term …
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Genomic signatures of recent selection at HIV host susceptibility genes in a Central African human population
… genotypes protective against HIV-1 for the ARGs CCR2, CCL3L1 and CCR5.
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