Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"CCNB1"”.
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Mathematical Modeling Reveals That G2/M Checkpoint Override
… of key mitosis-related genes including <em>CCNB1</em> and<em> PLK1</em>.</p> <p>Given accelerated G2/M checkpoint recovery in TSC2-null cells with mTORC1 hyperactivity, we postulated that further abrogation of the G2/M checkpoint may facilitate mitotic catastrophe and selectively kill cells. …
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Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors
… of key mitosis-related genes including <em>CCNB1</em> and<em> PLK1</em>.</p> <p>Given accelerated G2/M checkpoint recovery in TSC2-null cells with mTORC1 hyperactivity, we postulated that further abrogation of the G2/M checkpoint may facilitate mitotic catastrophe and selectively kill cells. …
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Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors
… of key mitosis-related genes including <em>CCNB1</em> and<em> PLK1</em>.</p> <p>Given accelerated G2/M checkpoint recovery in TSC2-null cells with mTORC1 hyperactivity, we postulated that further abrogation of the G2/M checkpoint may facilitate mitotic catastrophe and selectively kill cells. …
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Investigation of mTOR-independent regulation of macroautophagy
… role of CMGC kinase family members ERK1/2 and CCNB1-CDK1 in the regulation of autophagy. The ERK1/2 signalling cascade is activated in a high proportion of cancers. ERK2 has been proposed as a regulatory kinase of TFEB; however, we found little evidence to suggest that ERK1/2 was a direct …
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Determination of p53 role in cancer biology and therapy through interactome development and analysis
… and MAPK pathways and the cell cycle genes; CCNB1, CCNB2 along with KIF14, PDGFRB and SULF1. These offer potential for further investigation that could be exploited for greater therapeutic efficacy in sarcomatoid, and CYP24A1, HIPK4 and PEG3 in biphasic p53 (+/+) malignant mesothelioma …
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Biochemical and Functional Investigations into the Contribution of SOX17 Mutations to the Pathogenesis of Pulmonary Arterial Hypertension
… of decreased cyclin A (CCNA1) and cyclin B (CCNB1) expression and increased expression of p15 (CDKN2B), a cyclin-dependent kinase inhibitor. Additionally, siSOX17-transfected PAECs showed reduced monolayer permeability and impaired cellular angiogenesis, namely through horseradish peroxidase …