Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"CCM3"”.
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Structure-function Analysis of the STRIPAK Complex
… kinase regulators. Interestingly the protein CCM3, one of three proteins mutated in familial cases of cerebral cavernous malformations (CCMs), was also found to reside within the STRIPAK complex. My project focused on the structural and functional characterization of STRIPAK. I mapped direct …
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Investigation of the Molecular Mechanism for Cerebral Cavernous Malformations
… <italic>CCM2</italic>, or <italic>CCM3</italic>. Prior to the identification of the genes involved in pathogenesis, sporadic and inherited cases could be distinguished by lesion burden where sporadic cases exclusively showed single lesions, and patients with inherited disease …
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STK25 and TAO Regulate Muscle-Specific Transcription and Muscle Function in the Parasitic Flatworm Schistosoma Mansoni
… (STK25), or cerebral cavernous malformations 3 (CCM3) by RNAi in these worms produces a rapid and consistent deterioration consisting of detachment from the culture dish, drastic length reduction, selective paralysis in the worm body, and a distinctive "banana"-shaped morphology. Transplantation …
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KLF4 IS A KEY DETERMINANT IN THE DEVELOPMENT AND PROGRESSION OF CEREBRAL CAVERNOUS MALFORMATIONS
… mutations in any of three genes CCM1, CCM2 and CCM3 have been associated to familial CCM. Postnatal endothelial-specific deletion of any of the three Ccm genes in mice results in the development of multiple brain vascular malformations that faithfully resemble human CCM lesions. Here we describe …