Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"CCL21"”.
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Role of N-terminal residues of CCL19 and CCL21 in binding and activation of CCR7
… metastasis. In particular, chemokines CCL19 and CCL21 acting on their associated receptor CCR7 are postulated to be key drivers of lymph node metastasis in a number of malignancies including breast, colon, gastric, & thyroid cancers. It has been reported that the cleavage of the pre-cysteine …
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Ligand Bias by the Endogenous Agonists of CCR7
… Kinase (GRK)/ b-arrestin system. CCL19 and CCL21 are endogenous agonists for the chemokine receptor CCR7. They are known to be equipotent in promoting Gi/o mediated calcium mobilization, chemotaxis and inhibition of adenylyl cyclase activity. Here we test the hypothesis that these ligands …
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The role of CCR7 axis in facilitating chemoresistance, radioresistance and induction of cell proliferation in cancer
… receptor CCR7, activated by its ligands CCL19 & CCL21, is known to play a significant role in cancer metastasis. In view of the wider roles that chemokines play in the biology of the cell, we hypothesised that CCR7 could influence cancer progression through other mechanisms in particular …
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The Role of CCR7 and Its Ligands in a Behcet’s Disease Mouse Model
BACKGROUND: CCR7 and its ligands, CCL21 and CCL19, were known to establish microenvironment for the initiation of immune responses in secondary lymphoid tissue. It was reported that plt/plt (CCL21 and CCL19 gene-deleted) mice have defects in lymphocyte homing and DC localization. Recent studies …
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Molecular mechanisms of T cell homing in Hodgkin's lymphoma : implications for T-cell-based therapies
… Tumour cells expressed CXCL10, CXCL12 and CCL21. Vessels expressed ICAM-1, CXCL12, CCL17 and CCL21. Tumour cell lines secreted factors that mediated chemotaxis of lymphoblasts in vitro and TIL demonstrated chemotaxis to CXCL12 but not CCL17. VAP-1 was expressed on vessels and a …
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The role of the atypical chemokine receptor CCX-CKR in thymocyte development and its influence on the link between innate and adaptive immunity through regulation of dendritic cell migration.
… immune responses. Within the thymus CCL19, CCL21 and CCL25 direct CCR7- and CCR9-expressing thymocytes through distinct thymic compartments, enabling development of a self-MHC restricted and self-tolerant peripheral T cell repertoire. Yet mechanisms outside of transcriptional control that …
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Engineering chemoattractant gradients using controlled release polysaccharide microspheres
… general strategy for several chemokines, such as CCL21, CCL19, CXCL10 and CXCL12. The loading and release properties of individual chemokines were highly correlated with the average charge density on protein surface. We have also demonstrated that the controlled gradients created by ASCs were …
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Risk-Factor Induced Changes In The Breast Microenvironment Facilitate Inflammatory Breast Cancer Progression and Lymphovascular Invasion
… function to a similar extent. Increased CCL21+ cells, a ligand for lymphatic traffic homing, was correlated to pulsing. Thus, the relationship between lymphatic pulsing, tumor growth and CCR7-CCL21 related tumor trafficking warrant further investigation.</p> <p>CCR7 is an immune cell …
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Dendritic Cell Migration and Traction Force Generation in Engineered Microenvironments
… 10 to 100 fold more potent than other chemokines CCL21 or CXCL12. Interestingly, when the chemoattractive potencies of opposing gradients are matched, cells "home" to a central region in which the signals from multiple chemokines are balanced. These results provide fundamental insight into the …
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BREAST CANCER DURING PREGNANCY AS A SPECIAL TYPE OF EARLY-ONSET BREAST CANCER: INSIGHTS INTO THE TUMOR MICROENVIRONMENT AND IMMUNE TRANSCRIPTOME
… one (PECAM1) upregulated and 3 (CXCL1, CCL21, and HGF) downregulated. The TME and immune transcriptome of PrBC are characterized by specific patterns of TIL subpopulations and distinct gene expression patterns. Assessment of TILs and TILs subtyping in these patients might help to …
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cDNA microarray Analysis Identifies Symptom-Associated Chemokine Genes in Behcet's Disease Mouse Model
… CCR7 in lymph nodes. The expression patterns of CCL21, a ligand of CCR7, was expressed similarly among groups within the germinal center and lymphatic vessel of the lymph node. These results suggest CCR7, CCL28, their receptor and ligands are related to BD symptom patterns in our mouse model.
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On-Chip Engineered Human Lymphatic Microvasculature for Physio-/Pathological Transport Phenomena Studies
… by chemotactic gradients that trigger the CCR7-CCL21/19 and CXCR4-CXCL12 inflammatory axes. Finally, we demonstrate the utility of our microphysiological system for pre-clinical studies, specifically by screening the vascular absorption rate of therapeutic monoclonal antibodies developed by …
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New Aspects of Alveolar Adaptive Immune Responses in COPD
… as revealed by increased lymphatic expression of CCL21 and D6, both of which are involved in DC transport to lymphoid tissues. In conclusion, the studies in this thesis have discovered that the alveolar parenchyma in COPD lungs contain a novel type of DC-rich alveolar-lymphoid epithelium, elevated …
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Die Rolle von dendritischen Zellen und Chemokinen bei der Regulation der Immunantwort gegen Erreger der kutanen Leishmaniose
… bekannt, dass er die Chemokine CCL19/MIP-3β und CCL21/6Ckine, welche im Lymphknoten konstitutiv exprimiert werden, mit großer Affinität bindet und für die zielgerichtete Migration dendritischer Zellen in dieses Organ essentiell ist. Weitere Versuche ergaben zudem eine verstärkte …
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Functional Responses of Lung Dendritic Cell Subsets in Flt3 Ligand-Induced Immunomodulation in Allergic Asthma
… DC subsets to lymphatic chemokines CCL19 and CCL21. Thus, an involvement of KCa3.1 in lung DC migration is strongly implicated.|In conclusion, the administration of Flt3-L in the mice with allergic asthma causes several changes on lung DC properties leading to suppression of Th2 responses. …
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Chemotactic behavior of immature and mature blood cells in response to the cytokines: SDF-1, steel factor, CKbeta-11 and SLC
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Integrated Multimodal Analysis: Evaluating the Impacts of Chemotherapy and Electroporation-Based Therapy on Lymphatic and Blood Microvasculature in Cancer
The lymphatic and blood vascular systems are two important vessel networks that serve different roles in healthy states and in cancer. In breast cancer the most common cancer amongst women, mortality remains high despite increased treatment response due to metastatic spread, preferentially through …