Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 77 for “"CCL2"”.
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LKB1, CCL2, and Macrophages: A New Axis of Endometrial Cancer Progression
… dependent secretion of the inflammatory cytokine CCL2. Lkb1 inactivation in vivo resulted in abnormal production of CCL2, which led to recruitment of pro-tumorigenic macrophages (aka immunosuppressive macrophages) responsible for tumor invasion. Conditional inactivation of Ccl2 in an Lkb1-driven …
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Enzymatic cleavage of chemokines CCL2 and CXCL10 : Implications for multiple sclerosis pathogenesis.
… cell type in the CNS, and endothelial cells. CCL2 and CXCL10 are chemokines expressed in MS lesions, which are thought to be pivotal in chemoattraction of T cells and monocytes into the CNS. Astrocytes, microglia, and endothelial cells produce proteases, such as matrix metalloproteinases …
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Implicación de las quiomicinas CCL2 CCL5 en modelos de dolor neoplásico experimental.
… y se acompaña del aumento de la quimiocina CCL2. La mayor presencia espinal de CCL2 se relaciona con la activación de astroglía y microglía. También el bloqueo de los CCR1 previene la hiperalgesia derivada de la presencia de estas células NCTC 2472 y se relaciona con el aumento de CCL5. En …
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Assessing The Outcomes of Blocking Ccl2-Ccr2 Signaling Axis On Breast Cancer Brain Metastasis
… and increases the secretion of the chemokine CCL2, which enhances the chemotaxis of CCR2<sup>+</sup> myeloid cells, a major subpopulation of bone marrow-derived myeloid cells (BMDMs), from peripheral blood into the brain tumor microenvironment (TME), eventually promoting brain metastasis …
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Investigating the role of the CCL2/CCR2 axis in monocytes and its modulation by extracellular nucleotides
The chemokine CCL2 activates its cognate receptor CCR2 to orchestrate monocyte trafficking towards infected, inflamed, and injured tissues during immune responses and the development of inflammatory disease. However, despite research into this area being plentiful, CCR2 antagonists have lacked …
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Mise en évidence du rôle physiologique de la chimiokine CCL2 dans la neurotransmission nociceptive au niveau spinal
… in the immune response, we focused on the CCL2-CCR2 ability to regulate arthritic pain. We first evaluated the analgesic properties of INCB3344, a specific antagonist of the CCR2 receptor, in a model of inflammatory pain. It reverses both provoked and spontaneous pain by 50% when …
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The chemokine CCL2/CCR2 signaling mediates cancer associated fibroblasts-cancer cells interaction and promotes basal-like breast cancer progression
… We previously identified that the chemokine CCL2 was highly expressed in breast cancer associated fibroblasts. CCL2 is known to recruit monocyte/macrophage and promotes cancer progression. We previously found that recombinant CCL2 can directly signal to breast cancer cells and promote cell …
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Macrophage recruitment in DRG contributes to sensory axon regeneration after conditioning injury
… a novel chemokine signaling mediated by CCL2 that links regenerating neurons and macrophage activation with proregenerative phenotypes in the CI model. The expression level of CCL2 was significantly increased in injured DRG neurons, and cAMP significantly upregulated CCL2 expression in …
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Cytokines regulation of chemokine and chemokine receptor in relation to multiple sclerosis.
Expression of chemokines CXCL10 and CCL2 is elevated within inflammatory lesions in the central nervous system (CNS) of multiple sclerosis (MS) patients, particularly in astrocytes. These chemokines play a critical role in the recruitment of inflammatory cells into the CNS during inflammation. …
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Investigation of chemokine expression and modulation following traumatic brain injury
… monocyte chemoattractant protein-1 (MCP-1/CCL2) are derived from glial. However the origin of these chemokines following TBI, has not been established. Furthermore, little is known about the modulation of these chemokines: The relationship of serum levels of pro-inflammatory mediators such …
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Participación de los receptores de quimiocinas CCR1 y CCR2 en dolor inflamatorio y neoplásico en ratones
… El aumento local de la concentración de CCL2 en respuesta a una inflamación aguda o crónica contribuye al desarrollo de la hiperalgesia inflamatoria. Por ello, la hiperalgesia puede ser inhibida tanto a través del antagonismo del receptor CCR2 como de la neutralización de la CCL2. Del …
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Effects of β-funaltrexamine on lipopolysaccharide-induced inflammation and behavior
… hippocampus, and spleen tissues were harvested. CCL2, CXCL10, and IL-1β levels were measured in cell supernatant, CCL2 and CXCL10 were measured in frontal cortex, hippocampus, and spleen tissues, and IL-1β and corticosterone were measured in mouse plasma via ELISA. IDO1 and NLRP3 transcription …
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Investigation of the mechanisms underlying the development of atherosclerosis.
… and smooth muscle cells. The chemokines CCL2 and CX[3]CL1, which influence the migration of these leukocytes to sites of inflammation, have been implicated in disease progression. Whether testosterone has a modulatory effect on these orchestrating inflammatory molecules remains largely …
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Investigation Into The Molecular Mechanisms Underlying Idiopathic Intracranial Hypertension
… of IIH patients: chemokine (C-C motif) ligand 2 (CCL2), interleukin (IL)-17 (IL-17), IL-6, IL-1β, tumour necrosis factor-α (TNF-α), as well as adipocyte-derived hormone leptin and the glucocorticoid hydrocortisone (HC). <br></br><br></br> Female Wistar rats raised on a HF diet were shown to have …
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Die Rolle von dendritischen Zellen und Chemokinen bei der Regulation der Immunantwort gegen Erreger der kutanen Leishmaniose
… korreliert, sondern auch, dass das Chemokin CCL2/MCP-1 in der Lage ist, einen direkten Einfluss auf die intrazelluläre Erregerabwehr zu nehmen. Diese Arbeiten bezogen sich jedoch auf humane Hautbiopsien und aus Humanblut isolierten Zellen. Eine detaillierte Analyse des Infektionsverlaufes …
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The role of Interleukin-33 in retinal degenerative diseases
… of the inflammatory cytokines IL-1β, IL-6, CCL2, TNF∝, TGFβ and IL-33 were significantly increased at day 1 and then reduced gradually and returned to basal level by day 28. In IL-33KO mice, RD induced an exacerbated inflammation with increased CCL2, TNF∝, TGFβ and GFAP expression and …
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The role of the rho-associated coiled-coil containing kinase (ROCK) in cytokine-induced chemokine responses in intestinal epithelial cells
… Unlike CXCL8, the production of TNF-α-induced CCL2 and CCL20 expression was enhanced by ROCK inhibition in Caco-2 cells, indicating that ROCK activity had a suppressive effect on these responses. Further experiments showed that the ROCK-dependent suppression was likely mediated by ERK since the …
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O papel das quimiocinas na resposta imune de pacientes com leishmaniose mucosa
… às quimocinas em seus resumos. A produção de CCL2 e CXCL8 por macrófagos de pacientes com LM foi maior do que a produção de pacientes SC. Os níveis de CXCL9 foram significativamente maiores em paciente com LM comparados com paciente SC e grupo controle. De acordo com resultados preliminares …
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INITIATION OF EXPERIMENTAL ACUTE PANCREATITIS AND MODULATION OF INFLAMMATORY RESPONSE
… predominantly causes early expression of CCL2 [monocyte chemoattractant protein-1 (MCP-1)] and subsequent early influx of monocytes. Increased expression of CXCL [cytokine-induced neutrophil chemoattractant-1 (CINC-1)] was not seen and neutrophils were shown to appear in the tissue later …
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