Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"CCL19"”.
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Role of N-terminal residues of CCL19 and CCL21 in binding and activation of CCR7
… and metastasis. In particular, chemokines CCL19 and CCL21 acting on their associated receptor CCR7 are postulated to be key drivers of lymph node metastasis in a number of malignancies including breast, colon, gastric, & thyroid cancers. It has been reported that the cleavage of the …
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Ligand Bias by the Endogenous Agonists of CCR7
… Receptor Kinase (GRK)/ b-arrestin system. CCL19 and CCL21 are endogenous agonists for the chemokine receptor CCR7. They are known to be equipotent in promoting Gi/o mediated calcium mobilization, chemotaxis and inhibition of adenylyl cyclase activity. Here we test the hypothesis that these …
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Heterogeneity, Origins, and Role of Omental Macrophages in Health and Early Tumor Seeding
… reveal tumor suppressive CX3CR1+ ORM rely on Ccl19+ fibroblastic reticular cells to migrate to each tumor to restrict its growth. Additionally, we observed CCL19+ fibroblast like cells in the meninges and the cornea layer of the eye. As the central nervous system (CNS) requires precise control …
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ROLE OF THE MUCOSAE-ASSOCIATED EPITHELIAL CHEMOKINE (MEC/CCL28) IN THE MODULATION OF THE IMMUNE RESPONSE AGAINST VIRAL INFECTIONS
… 14. Mice were euthanized on day 28. The murine CCL19 expression vector was used as negative control, as this chemokine binds to CCR7 receptor. HIV1IIIB-VLPs, HPV16-VLPs and CCL28- and CCL19-expressing plasmids were administrated intramuscularly; H7N1-VLPs were administrated intraperitoneally. …
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The Role of CCR7 and Its Ligands in a Behcet’s Disease Mouse Model
BACKGROUND: CCR7 and its ligands, CCL21 and CCL19, were known to establish microenvironment for the initiation of immune responses in secondary lymphoid tissue. It was reported that plt/plt (CCL21 and CCL19 gene-deleted) mice have defects in lymphocyte homing and DC localization. Recent studies …
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An investigation of how dendritic cell migration is modulated during Leishmania mexicana infection
… (DCs) towards the lymphatic vessel network and CCL19-producing lymph node is a key step in the induction of adaptive immunity. Consequently, manipulation of chemokines and chemokine receptors presents a potential mechanism by which parasites can evade protective host immunity. Therefore, the aim …
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The role of the atypical chemokine receptor CCX-CKR in thymocyte development and its influence on the link between innate and adaptive immunity through regulation of dendritic cell migration.
… of adaptive immune responses. Within the thymus CCL19, CCL21 and CCL25 direct CCR7- and CCR9-expressing thymocytes through distinct thymic compartments, enabling development of a self-MHC restricted and self-tolerant peripheral T cell repertoire. Yet mechanisms outside of transcriptional control …
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Disrupting Tymp-Mediated Pathways to Block Lymph Node Metastasis in Ovarian Cancer
… we identified that CCR7 (epithelial cancer cell)-CCL19 (macrophage or dendritic cells) axis plays a key role in LN metastasis, with TYMP knockdown resulting in reduced CCR7 expression. This work provides a new understanding of the modes of ovarian cancer metastasis and further points to TYMP as a …
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Engineering chemoattractant gradients using controlled release polysaccharide microspheres
… strategy for several chemokines, such as CCL21, CCL19, CXCL10 and CXCL12. The loading and release properties of individual chemokines were highly correlated with the average charge density on protein surface. We have also demonstrated that the controlled gradients created by ASCs were similar to …
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Dendritic Cell Migration and Traction Force Generation in Engineered Microenvironments
… We show that in counter gradients, CCL19 is 10 to 100 fold more potent than other chemokines CCL21 or CXCL12. Interestingly, when the chemoattractive potencies of opposing gradients are matched, cells "home" to a central region in which the signals from multiple chemokines are …
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The role of CCR7 axis in facilitating chemoresistance, radioresistance and induction of cell proliferation in cancer
… receptor CCR7, activated by its ligands CCL19 & CCL21, is known to play a significant role in cancer metastasis. In view of the wider roles that chemokines play in the biology of the cell, we hypothesised that CCR7 could influence cancer progression through other mechanisms in particular …
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cDNA microarray Analysis Identifies Symptom-Associated Chemokine Genes in Behcet's Disease Mouse Model
… inactive and BD eye. The expression patterns of CCL19, a ligand of CCR7, was similar to CCR7 in lymph nodes. The expression patterns of CCL21, a ligand of CCR7, was expressed similarly among groups within the germinal center and lymphatic vessel of the lymph node. These results suggest CCR7, …
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Investigating The link Between High-Risk Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Haplotypes, Periodontal Inflammation and Depression in People With HIV (PWH) on Antiretroviral Therapy ( ART)
… of proinflammatory cytokines (CCL11, CCL19, CD8A, CXCL8, and FGF-19) in serum and (CSF3 and IL-1β) in gingival crevicular fluid (GCF). Race- and sex-stratified analyses demonstrated unique cytokine profiles, with elevated levels of CCL23, CXCL5, FGF5, and DNER in individuals of African …
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Investigation of novel therapeutic strategies in B cell and antibody mediated disease
… chemotaxis to chemokine (C-C motif) ligand 19 (CCL19) was abrogated by the addition of I-BET. In vivo, two photon imaging showed that systemic I-BET treatment reduced IC-induced dermal DC mobilisation. Tissue DCs and transferred DC also had reduced migration to draining lymph nodes following …
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Die Rolle von dendritischen Zellen und Chemokinen bei der Regulation der Immunantwort gegen Erreger der kutanen Leishmaniose
… Rezeptor ist bekannt, dass er die Chemokine CCL19/MIP-3β und CCL21/6Ckine, welche im Lymphknoten konstitutiv exprimiert werden, mit großer Affinität bindet und für die zielgerichtete Migration dendritischer Zellen in dieses Organ essentiell ist. Weitere Versuche ergaben zudem eine verstärkte …
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Functional Responses of Lung Dendritic Cell Subsets in Flt3 Ligand-Induced Immunomodulation in Allergic Asthma
… of both lung DC subsets to lymphatic chemokines CCL19 and CCL21. Thus, an involvement of KCa3.1 in lung DC migration is strongly implicated.|In conclusion, the administration of Flt3-L in the mice with allergic asthma causes several changes on lung DC properties leading to suppression of Th2 …