Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"CCL17"”.
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Aumento diferencial da expressão de IL13 e CCL17 em mucosite: uma análise comparativa com saúde e peri-implantite
… avaliar a alteração da expressão dos genes IL8, CCL17 e IL13 em relação a classificação peri-implantar diagnosticada como saúde, mucosite ou peri-implantite. Foram incluídos no presente estudo 36 participantes da pesquisa atendidos na clínica de manutenção peri-implantar da Universidade Federal …
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The role of dendritic cells and their chemokine TARC in the pathogenesis of atherosclerosis
In this study, the DC-derived chemokine CCL17 and its role in the pathogenesis of atherosclerosis was investigated. By using a ‘knock-in’ mice expressing a targeted replacement of the Ccl17 gene by eGFP, we observed that CCL17+ DCs belong to a mature subpopulation of cDCs related to the myeloid …
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Molecular mechanisms of T cell homing in Hodgkin's lymphoma : implications for T-cell-based therapies
… and CCL21. Vessels expressed ICAM-1, CXCL12, CCL17 and CCL21. Tumour cell lines secreted factors that mediated chemotaxis of lymphoblasts in vitro and TIL demonstrated chemotaxis to CXCL12 but not CCL17. VAP-1 was expressed on vessels and a tissue-binding assay was evaluated to examine VAP-1 …
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Die Funktion von intrazerebralen Makrophagen beim Staphylococcus aureus- induzierten Hirnabszess im Kontext der IL-4R-abhängigen Aktivierung
… Mrc1 (CD206), Clec10a (CD301), Chi3l3 (Ym1) und Ccl17 und zusätzlich von fibroseinduzierenden Zytokinen wie Il10 und Tgfb1. Zudem konnten sogenannte alternativ aktivierte CD206+-Makrophagen in direkter Umgebung der schützenden Kollagenkapsel nachgewiesen werden und zeigten eine räumliche …
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Correlation Matrix Analysis Identifies Gene Signatures of Immune Cell Subsets and Their Interactions In Follicular Lymphoma
… B-cell receptor signaling, and induction of CCL17 and CCL22 by tumor B cells. This novel analytical approach may be broadly applicable to define gene signatures of rare immune cell subsets in the tumor microenvironment, determine their prognostic impact, discover novel therapeutic targets, …
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Design and development of an electrochemical and infrared spectroscopic medical device for serum-based cancer diagnostics
… to electrochemically detect the biomarker CCL17/TARC at387-50,000pg/ml concentrations with R2 = 0.979 and limit of detection of 387pg/mlin spiked buffer samples. Thereafter, the medical device demonstrated successfuldiagnosis of Hodgkin’s lymphoma in all 11 tested clinical patient …
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Identification of Novel CCR4 Antagonists Through Inhibition of CCL22-Induced Cell Migration
… 22 (CCL22) and C-C motif chemokine ligand 17 (CCL17) which subsequently activate CCR4+ nociceptors to cause pain. This activation results in mechanical and thermal hypersensitivity blocked by C 021, a known CCR4 antagonist. This discovery highlighted CCR4 as a potential target for developing …
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The Regulation and Function of Thymic Stromal Lymphopoietin Receptor (TSLPR) in the Airway Epithelium
… is functional, as epithelial cells produce CCL17, a T<sub>H</sub>2-associated chemokine, in response to stimulation with TSLP. These data suggest that a direct autocrine or paracrine response to TSLP by epithelial cells may initiate the first rounds of chemotaxis during an allergic …
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Delineating The Roles of IL-12 and IL-23 Produced by Dendritic Cells in Eliciting CD8+ T Cell Resonses Against Listeria Monocytogenes
… increased production of the chemokines CCL1 and CCL17 by WT, but not IL-12 deficient DC. Neutralization of both chemokines resulted in reduced IFN-γ production, demonstrating their importance in priming naïve CD8+ T cells. These chemokines did not influence CD4+ T cell IFN-γ production. To …
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Role of Macrophages in Ocular Surface Fibrosis
… gene expression and secretion of chemokines CCL17 and CCL22.</p> <p>In conclusion, our data demonstrates that macrophages could play a key role in the pathology of oGVHD-associated fibrosis due to their likely activation in response to irradiation and cross-talk with ocular surface …
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Linking Inflammation to Tumorigenesis In A Mouse Model of High-Fat Diet-Enhanced Colon Cancer: Does Fat Type Matter?
… certain markers of M1 (IL-12) and M2 (CD206 and CCL17) macrophages were significantly increased in the HFD-6% group but not the HFD-12% or HFD-24%. As expected, all HFD treatments increased inflammatory mediators but this effect was greatest with the HFD-12% and HFD-24% groups. We report that a …
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Dietary supplementation for the treatment of hyperpnoea induced bronchoconstriction in physically active asthmatics
… serum concentrations of TNF-α (reduced by 36%), CCL17 (reduced by 22%), and C-reactive protein (reduced by 11%) in the HIB participants. For the first time this suggests that favourable manipulation of the commensal bacteria within the gut by B-GOS will influence immune regulation and …