Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"CCK"”.
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Combinatorial approach to multi-substituted 1,4-Benzodiazepines as novel non-peptide CCK-antagonists
… The combinatorial library was evaluated in a CCK radiolabelled binding assay and CCKA (alimentary) and CCKB (brain) selective lead structures were discovered. The template of CCKA selective 1,4-benzodiazepin-2-ones bearing the tryptophan moiety was chemically modified by selective alkylation …
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Central mechanisms underlying the synergistic anorectic effect of CCK and GLP-1 combination therapy
… of diabetes and obesity. Cholecystokinin (CCK) and Glucagon-like peptide-1 (GLP-1) are gut hormones produced in response to meal ingestion that promote satiety and meal termination. Co-infusion of long-acting CCK and GLP-1 receptor agonists have been shown to synergistically reduce food …
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Effets de la CCK [indice] 4 et de différents stress expérimentaux sur les concentrations cérébrales de diverses amines biogènes
… de vérifier si l'administration systémique de la CCK [indice] 4 (cholecystokinine tetrapeptide), qui induit des symptômes d'anxiété chez l'humain et chez l'animal, produisait des changements neurochimiques au cerveau, lesquels changements pourraient sous-tendre l'expression de ces symptômes. Cet …
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Effets d'une immunomodulation de la leptine et de la cholécystokinine chez le rat en croissance
… meal-related intestinal signal cholecystokinin (CCK) and the adipose tissue-produced leptin are known as satiety hormones. Their interaction induces long- and short-terms effects. The aim of this study is to examine the zootechnical and endocrinal effects of an active immunomodulation of both CCK …
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Regulation of Neuronal Excitability by Glutamate and Cholecystokinin Rodent Neocortex
… be modulated by neuropeptides. Cholecystokinin (CCK) is one of many neuropeptides localized in the central nervous system with relatively high concentrations in the cerebral cortex. Layer VI neocortical neurons provide important corticothalamic innervation that can modulate information processing …
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New paradigm for drug design: Design and synthesis of novel biologically active peptides that are agonists at opioid receptors and antagonists at cholecystokinin receptors
… of neurotransmitters such as cholecystokinin (CCK) in which both the peptides and their receptors are increased in pain states. To effectively treat diseases involving "systems changes" a new paradigm for the design of compounds was proposed. In this new approach single peptide or …
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Defining a Neuroprotective Pathway for the Treatment of Ataxias
… of the peptide hormone Cholecystokinin (Cck) in these mice. Knocking out Cck or the Cck1 receptor (Cck1R) in ATXN1[30Q]D776 mice confers a progressive disease where PC death occurs by thirty-six weeks of age. Weighted Gene Co-expression Network Analysis (WGCNA) performed on cerebellar …
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Brain distribution and release of Cholecystokinin octapeptide
… thesis the in vitro release of immunoreactive CCK₈ (iCCK₈) from rat central nervous system preparations and the regulation of this release have been studied. Rat brain was dissected into the following regions; hypothalamus, cerebral cortex, striatum and thalamus, according to the method of …
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Molecular biology and biochemistry of brain tumours
… present study concentrates on cholecystokinin (CCK), a gut-brain peptide that has been described to be able to induce mitosis of rat gliomas as well as hormone secretion by the anterior pituitary, via the CCK-B receptor. The significance of a polymorphism in the growth hormone releasing hormone …
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Cholecystokinin Action at CCK1 Receptors in the Brain to Produce Satiety in Rats
Cholecystokinin (CCK) is a peptide that is found throughout the brain and in neurons and endocrine cells of the gastrointestinal tract. Studies demonstrating that systemic administration of the CCK1 receptor antagonist devazepide increases food intake in a variety of species provide compelling …
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Interactions of islet hormones with acetylcholine and cholecystokinin-octapeptide in the isolated pancreas of normal and diabetic rats
… the gut hormone cholecystokinin octapeptide (CCK-8), sodium nitroprusside (SNIP), 8-Bromo guanosine 3'5' cyclic monophosphate (8-Br cOMP) and nerve stimulation on amylase secretion and intracellular free calcium concentration ([Ca 2 ]) in the isolated pancreas of normal and diabetic rats. The …
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Mechanism of exocrine pancreatic insufficiency during diabetes mellitus
… and the gut hormone cholecystokinin-octapeptide (CCK-8), measuring the amylase output, intracellular free calcium concentration ([Ca2i), intracellular free magnesium concentration ([Mg2 ]) and pancreatic juice secretion in the isolated pancreatic segments and the anaesthetised rat preparations of …
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The Effect of Cholecystokinin Antagonist Lorglumide on Dopamine Levels in the Rat Caudate
Systemic administration of the CCK-A receptor antagonist lorglumide has been shown to block voltammetrically detected dopamine (DA) signals associated with slow wave depolarization (SWD) in the rat caudate (CPu). Failure to elicit KC1-induced DA signals following lorglumide treatment may be due to …
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The synthesis and evaluation of small organic molecules as cholecystokinin antagonists
Cholecystokinin (CCK) is a peptide hormone, present in the alimentary and the CNS. It is the most abundant peptide in the brain. CCK has been implicated in a number of disorders. The link between CCK and anxiety was the basis for this research. A comprehensive discussion on the many types of CCK …
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Cholecystokinin und Ghrelin
Abstract: Hintergrund: Cholezystokinin (CCK) ist ein anorexinogenes Hormon. Den Neuropeptiden NUCB2/Nesfatin-1, Corticotropin-releasing-factor (CRF), Oxytocin (OXY) sowie dem Cocaine and amphetamine-regulated-transcript (CART) wird eine Rolle bei der zentralen Vermittlung von CCK-Effekten auf die …
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The role of the free fatty acid, lauric acid, in appetite regulation and its potential as an appetite-suppressant.
… both C12 and C10 stimulate cholecystokinin (CCK) secretion, however, the effect of C12 was much greater. A previous study in humans has also shown that intraduodenal administration of a long-chain fatty acid, such as oleic acid, a monounsaturated fatty acid with 18 carbon atoms (“C18:1”), …
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Neuroepithelial Signalling in the Colon
… are also expressed including cholecystokinin (CCK) which is associated with a worsening of postprandial abdominal pain and visceral hypersensitivity in IBS. Consequently, this thesis sought to understand the contribution of signalling mediators and hormones of the gut mucosa to colonic sensory …
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