Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"CCAAT-Enhancer-Binding Protein-beta"”.
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Roles of CCAAT/enhancer-binding protein [beta] and [-delta] in immunoglobulin G immune complex-induced Inflammation
<p>CCAAT/enhancer-binding protein (C/EBP) &beta and C/EBP&delta are known to participate in the regulation of many genes associated with inflammation. However, little is known about the activation and function of C/EBP&beta and -&delta in inflammatory responses elicited by Fc&gamma receptor …
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In Vivo Studies on the Transcriptional and Posttranslational Regulation of the CCAAT/Enhancer Binding Protein Beta
The transcription factor C/EBPbeta gene has CREB responsive elements (CRE) in its promoter, and its transcription is regulated by CREB during adipogenesis. We have generated a mouse line with a deletion of the CRE elements on the C/EBPbeta promoter and stusied the role of these elements in …
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Analysis of the Role of the Transcription Factor C/EBPbeta in Controlling Uterine Functions During Early Pregnancy
… efforts, we identified the transcription factor, CCAAT Enhancer Binding Protein Beta (C/EBPbeta) as a prominent target of estrogen and progesterone signaling in the uterus. The development of a C/EBPbeta-null mouse model, which is infertile, presented us with an opportunity to analyze the role of …
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Analysis of the role of the transcription factor C/EBPβ in controlling uterine functions during early pregnancy
… efforts, we identified the transcription factor, CCAAT Enhancer Binding Protein Beta (C/EBPb) as a prominent target of estrogen and progesterone signaling in the uterus. The development of a C/EBPb-null mouse model, which is infertile, presented us with an opportunity to analyze the role of this …
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P53 Maintains Hepatic Cell Identity During Liver Regeneration
… (ChIP-Seq) allowed detection of genome-wide binding of p53 to target genes in liver. We found 5074 <em>de novo </em>p53 target genes, 92% of which participate in non-canonical p53 functions, mainly developmental processes. Integration of ChIP-Seq findings with global expression profiling …
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Steroid Hormone Regulation of Implantation
… these targets we have used microarray analysis. CCAAT enhancer binding protein beta (C/EBP beta) was identified as target of both E and P that helps in the uterine epithelial proliferation followed by participation in both uterine stromal cell proliferation and differentiation. These results are …
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Understanding C/EBPbeta LAP/LIP Transcriptional and Adipogenic Potential Through Regulation by HDAC1 and GCN5
The CCAAT/Enhancer Binding Protein Beta (C/EBPβ) is part of the leucine zipper family of transcription factors and is involved in a myriad of processes including cellular proliferation and differentiation. C/EBPβ is expressed as three isoforms (LAP*, LAP, LIP), translated from a single mRNA by a …
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CROSSTALK BETWEEN LYSOPHOSPATIDIC ACID (LPA) AND TRANSFORMING GROWTH FACTOR BETA (TGFβ) IN BREAST AND OVARIAN CANCER CELLS
… acid (LPA) and transforming growth factor beta (TGFβ) are platelet-derived intercellular mediators of cell proliferation and motility. LPA is a general growth, survival and motility-stimulating factor in mammalian cells. TGFβ prevents proliferation of normal epithelial cells. However, the …
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Regulation of Pyruvate Dehydrogenase Kinase 4 by Thyroid Hormone / Role of Peroxisome Proliferator Activated Receptor Gamma Coactivator-1 alpha and Ccaat Enhancer Binding Protein
… in a ligand dependent manner. To identify a binding site for the TRβ in the promoter of the PDK4 gene, I transfected serial deletions of this promoter ligated to the luciferase reporter gene into the human hepatoma (HepG2) cells. The TRβ binding site was characterized by gel shift mobility …
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C/EBPβ Regulates Tumour Size and Microenvironment Composition in Lewis Lung Carcinoma
CCAAT/enhancer-binding protein beta (C/EBPβ) is a critical transcription factor involved in cellular differentiation, inflammation, and metabolic regulation. Although C/EBPβ has been implicated in both oncogenic and tumour-suppressive functions across different cancer types, its role in lung …
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The avian maternal environment: Its influence on the physiological mechanisms contributing to progeny production efficiency in chicken meat birds
… Furthermore the relative mRNA expression of the CCAAT/enhancer-binding protein beta (CEBP/β) was increased in CORT treated birds. Additionally, total yolk lipid content was decreased in CORT treated birds at hatch. In summary, this thesis examined the effects of the maternal environment and …
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Analysis of the role of the transcription factor-C/EBPβ in implantation
During early pregnancy, the concerted actions of the maternal steroid hormones, estrogen and progesterone, promote a unique process known as decidualization, which involves extensive proliferation and differentiation of uterine stromal cells. The molecular pathways underlying this hormonally …