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Showing 1 to 2 of 2 for “"CBX8"”.
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Significance of Protein Interactions in Mediating AF9 Function
… members of Polycomb group PRC1 complex, CBX8, RING1B, and BMI1. The interaction of AF9 with other PRC1 proteins is directly mediated by CBX8 and precludes AF9-DOT1L binding. Knockdown of CBX8 with shRNA leads to decreased ENaCα mRNA levels. In contrast, CBX8 overexpression results in …
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The Role of AF9 and AF9-Mediated Protein Interactions in Hematopoiesis and Leukemogenesis
… proteins such as AF4/AF5q31, DOT1L, Pc3/CBX8 and BCoR. These interactions are retained in the oncogenic MLL-AF9 fusion protein, and may be required for leukemic transformation.</p><p>Using bone marrow progenitor cells isolated from conditional Af9 knockout mice, we examined in vitro …