Global ETD Search
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Showing 1 to 7 of 7 for “"CBP/p300"”.
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Characterization of Transcription Factor-Coactivator Complexes in Acute Lymphoblastic Leukemia
… recruitment of the transcriptional coactivator CBP/p300. Indeed, previous studies have shown that E2A-PBX1-mediated oncogenesis requires direct binding of E2A-PBX1 to CBP/p300. However, the transcriptional targets of this complex remain unknown. Additionally, as t(1;19)-mediated ALL is derived …
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Molekularbiologische Untersuchung intrazellulärer Signalwege, die in T-Lymphozyten zur Aktivierung des Transkriptionsfaktors NF-ATc führen
… NF-ATc über die transkriptionellen Koaktivatoren CBP und p300 entfalten, die an die N-terminale transaktivierende Domäne TAD-A von NF-ATc binden und dessen Aktivität kontrollieren. Der Nachweis, daß konstitutiv aktive Mutanten von c-Raf und Rac synergistisch die CBP/p300-vermittelte …
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Mutational analysis of the human histone chaperone, Nap1, in nucleosome disassembly at the HTLV-1 promoter
… cellular coactivators CREB binding protein (CBP)/p300, acetyl coenzyme A (acetyl CoA), acceptor DNA and nucleosome assembly protein (Nap1). Tax and pCREB recruit the histone acetyltransferase, CBP/p300, which acetylates histone tails prior to disassembly of the octamer. Nap1 is unique in this …
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MOLECULAR STUDY OF CHROMATINOPATHIES: THE CASE OF RUBINSTEIN-TAYBI AND RETT SYNDROMES
… syndrome (RSTS) is characterized by CBP/p300 lysin-acetyltransferases deficit, while classic form of Rett syndrome (RTT) is caused by mutations in the reader MECP2. Both disorders show neurodevelopmental defects and 10 to 30% of patients remains without a molecular diagnosis. Methods: …
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Signal transduction of transforming growth factor-Beta in cytotoxic T cells
… im Zusammenspiel mit Transkriptionsfaktoren wie CBP/p300 oder AP-1 die Transkription TGF-b-spezifischer Zielgene koordinieren. Neue Erkenntnisse lassen vermuten, daß die pleiotropen Effekte von TGF-b durch das Interagieren mit anderen Signalkaskaden entstehen, zum Beispiel mit dem MAP-Kinase-Weg …
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Interpreting Notch signals: characterisation of dynamic transcription hubs by live imaging
… in stabilising Mam were investigated, with CBP/p300 and the CDK8 module of the Mediator complex recruited to the transcription hub and required for transcription. However, of the two complexes, only the CDK8 module had an influence on Mam recruitment at the target locus. Further …
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Examining the effect of CBP on the E2A-PBX1 and HOXB4 interaction
… domain (KIX) of the transcriptional coactivator CBP and demonstrated a requirement for this interaction in leukemia induction. Others have shown that HOX proteins and CBP also interact directly, with resulting inhibitory effects on the DNA-binding ability of HOX proteins and on the acetylation of …