Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 83 for “"CBP"”.
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Examining the effect of CBP on the E2A-PBX1 and HOXB4 interaction
… domain (KIX) of the transcriptional coactivator CBP and demonstrated a requirement for this interaction in leukemia induction. Others have shown that HOX proteins and CBP also interact directly, with resulting inhibitory effects on the DNA-binding ability of HOX proteins and on the acetylation of …
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Phosphorylation of Glucocorticoid Receptor tau1c Transactivation Domain Enhances Binding to CREB Binding Protein (CBP) TAZ2 and a Microfluidic, High Throughput Protein Crystal Growth Method for Microgravity
… (CH3) of the co-activator CREB binding protein (CBP). Because CH3 overlaps the CBP transcriptional adaptor zinc binding (TAZ) 2 domain, implicated in phosphorylation dependent binding to other unstructured transcription factor domains, we investigated if GR interacts with TAZ2 and whether this …
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Characterization of Transcription Factor-Coactivator Complexes in Acute Lymphoblastic Leukemia
… recruitment of the transcriptional coactivator CBP/p300. Indeed, previous studies have shown that E2A-PBX1-mediated oncogenesis requires direct binding of E2A-PBX1 to CBP/p300. However, the transcriptional targets of this complex remain unknown. Additionally, as t(1;19)-mediated ALL is derived …
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Alkanes as Internal and External Markers in Horses and the Digestibility of a High Fat Cereal By-Product
… and the same hay plus a cereal by-product (H + CBP). The cereal by-product (CBP) was the high fat component added to feeds at Virginia Tech's Middleburg Agricultural Research and Extension Center. The apparent digestibility of ether extract (EE) and other nutrients in the H and H + CBP, as well …
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Interferon-gamma suppresses melanogenesis in B16 melanoma cells and primary human melanocytes
… on MITF promoter by reducing the binding of CBP and CREB. These results suggest that IFN-γ decreases melanogenesis through inhibiting the binding of CBP and CREB and block the MITF and tyrosinase expression. Inflammatory cytokines are closely related to melanogenesis in melanocytes. Here, I …
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Manipulating Paradigm and Attention via a Mindfulness Meditation Training Program Improves P300-Based BCI.
… test the efficacy of the checkerboard paradigm (CBP) against the standard row-column paradigm (RCP). Online results show that MMTP had greater accuracies than CTRL and that CBP outperformed the RCP. MMTP participants provided greater amplitude positive target responses, but these differences were …
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Molekularbiologische Untersuchung intrazellulärer Signalwege, die in T-Lymphozyten zur Aktivierung des Transkriptionsfaktors NF-ATc führen
… NF-ATc über die transkriptionellen Koaktivatoren CBP und p300 entfalten, die an die N-terminale transaktivierende Domäne TAD-A von NF-ATc binden und dessen Aktivität kontrollieren. Der Nachweis, daß konstitutiv aktive Mutanten von c-Raf und Rac synergistisch die CBP/p300-vermittelte …
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Probing the dynamic scaling hypothesis in 1-D coarsening particle systems
… in particular, the coarsening-ballistic particle CBP* model and the coarsening reverse-parabolic CRP** model. We utilize an in-house code developed by Watson et al. to generate the morphometric data and we show that The Dynamic Scaling Hypothesis holds for the CBP* model but does not hold for the …
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Molecular mechanisms of Kruppel-like Factor 4
… domain of KLF4 recruits the co-activator p300/CBP to the promoter of the positively-regulated gene IAP, resulting in increased histone acetylation. On the negatively regulated gene, Cyclin B1, I demonstrate that KLF4 recruits HDAC3, decreasing histone acetylation. In addition, I show that KLF4 …
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Investigation of the Role of Histone Acetylation in Hippocampus-Dependent Memory Formation
… histone acetyltransferase CREB-binding protein (CBP) impairs long-term memory formation, and pharmacologically blocking histone deacetylases (HDAC) enhances long-term memory formation. Memory enhancement by HDAC inhibitors requires the interaction between the transcription factor CREB and CBP, …
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Surface Modifications of Iron Oxide Nanoparticles for Magnetic Imaging and Diagnosis
… creating a novel vehicle for drug delivery. SNIO–CBP, product from conjugating functionalized SNIO nanoparticles with a nature-inspired cyclic collagen-binding peptide (CBP) through newly developed preparatory copper-catalyzed alkyne–azide coupling CuAAC, exhibited binding affinity towards type I …
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Role of P300 Zz Domain In Chromatin Association and Histone Acetylation
… paralogue CREB-binding protein (CREBBP, aka CBP) are well-known transcriptional coactivators that have intrinsic lysine acetyltransferase activity. The functions of p300/CBP largely rely on their capabilities to bind to chromatin and to acetylate the histone substrates. However, the molecular …
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Analysis of truck delays at container terminal security inspection stations
… United States Customs and Border Protection (CBP) has set up inspection stations for containers at seaport terminals to screen containers, but this practice affects the truck turnaround time in the seaport by generating additional processing delays. This dissertation analyses the additional …
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Diagenesis And Controls On Porosity And Permeability In The Upper San Andres Formation Of West Texas
… Texas reservoirs on the Central Basin Platform (CBP) are dominated by Permian-age carbonate deposits, significantly contributing to petroleum production. The Upper Permian-aged San Andres Formation, composed primarily of dolomite and limestone, is a prolific reservoir. This study assesses …
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A Role for Glycogen Synthase Kinase 3 beta in the Regulation of Glucagon Gene Transcription by Insulin
… transkriptionsaktivierende Wirkung von Pax6 und CBP wurde durch den GSK3 Inhibitor SB-216763 aufgehoben. Dies wurde in einem GAL4-System gezeigt. Rekombinantes GSK3b phosphorilierte die Transaktivierungsdomäne von Pax6 und ein CBP-Fragment, das die Aminosäuren 2040-2305 enthielt. Dies konnte …
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Conformational Analysis of Disordered Proteins Using H/D Exchange Mass Spectrometry
… the interacting domains of CREB binding protein (CBP, residues 2059-2117) and activator of thyroid and retinoid receptors (ACTR, residues 1018-1088), were analyzed using H/D-MS. CBP and ACTR represent two classes of IDPs: the molten globule and random coil, respectively. The mutual synergistic …
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Novel Host Materials for Blue Phosphorescent Organic Light-Emitting Diodes
… material, 4,4’-bis(carbazol-9-yl)-2,2’-biphenyl (CBP), was optimised by introducing torsion via methyl or trifluoromethyl substituents in the 2- and 2’-positions of the central biphenyl moiety to yield twisted CBP-derivatives. By confining the conjugated system in combination with selective methyl …
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Multimodal Cancelable Biometric System
… Fusion (CFF) and Cancelable Binary Pattern (CBP), respectively. CFF combines multiple biometric traits using random indexes so that for every fusion it generates a new fused template. Developed 2-Fold Cross-Folding (2-CF) and Generalized Cross-Folding (G-CF) are new algorithms for cancelable …
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Psychosomatic aspects on diabetes and chronic pain Alexithymia, depression and salivary cortisol The Affect School and Script Analysis Therapy
… and soma in diabetes and in chronic benign pain (CBP). Interventions with Affect School and Script Analysis (ASSA) compared to Basic Body Awareness Therapy (BBAT) are tried. In a feasibility and treatment efficacy study we offered ASSA to 59 patients with CBP, and 54 (92%) completed. Alexithymia …
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