Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"CBL"”.
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CBL and CBL-B Dictate CSF-1R Endocytic Traffic and Signaling in Macrophages
… makes the discovery that the ubiquitin ligases Cbl and Cbl-b cooperate to regulate CSF-1R endocytosis and traffic to macropinosome in macrophages. Macrophages were derived from mice knocked out for Cbl, Cbl-b or the double knock out (DKO). DKO macrophages hyperproliferated, matching the severe …
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Role of c-Cbl in Invasion of Mammalian Cells by Rickettsia Conorii
… leads to a rapid ubiquitination of Ku70 by c-Cbl, followed by the entry of R. conorii into the host cell. However, the role of c-Cbl in ubiquitinating Ku70 and communicating with the invading bacterium remain to be clarified. Based on the report of Martinez et al and other groups on the roles …
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The Derivation, Implementation and Evaluation of a Model for CBL Specification and Design
… and implementation of a Computer Based Learning (CBL) design and development model UDRIPS, UDRIPS stands for Universal picture; Definitions; Rules; Illustrative examples; Problem solving; Summary. The need for the model was highlighted as a result of involvement in the Teaching and Learning …
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Nur77 Prevents Excessive Osteoclastogenesis by Inducing Ubiquitin Ligase Cbl-b to Mediate NFATc1 Self-Limitation
… up-regulates E3 ubiquitin ligase Cbl-b, which triggers NFATc1 protein degradation. These findings not only identify Nur77 as a key player in osteoprotection and a new therapeutic target for bone diseases, but also elucidate a previously unrecognized NFATc1→Nur77→Cblb→NFATc1 …
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E3 Ubiquitin Ligase Cbl-b deficient T cells resist Treg cell-mediated suppression and enhance anti-tumor immunity
… investigated the role of E3 ubiquitin ligase Cbl-b in establishing T cell resistance to Treg cell-mediated suppression. First, we found that the absence of Cbl-b, a negative regulator of multiple TCR signaling pathways, rendered CD8+ T cells impartial to Treg cell-mediated suppression. …
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Case-Based Learning (CBL) in Selected Physical Therapy Curricula and Its Perceived Effectiveness by Students, Faculty, and Administrators
Case-based learning (CBL) is commonly used in physical therapy curricula even though not much evidence exists as to the effectiveness of this instructional tool in physical therapy education. Through qualitative evaluation methodology, the researcher investigated the utilization and implementation …
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The Relationship between Cobalamin Deficiency and Neurological Dysfunction in Older Adults
… estimated to be between 14% and 23%. Persistent Cbl deficiency can cause a variety of neurological deficits. Neurological dysfunction occurs commonly among older adults, raising the research question whether or not there is a relationship between the high prevalence of Cbl deficiency and …
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Functional Redistribution of Hippocampal Cannabinoid Cb1 Receptors in the Rat Pilocarpine Model of Acquired Epilepsy
… marijuana derivative Δ9-THC, are known to have CBl receptor-mediated anticonvulsant effects in several animal models of seizures and epilepsy, including the rat pilocarpine model of acquired epilepsy. However, the distribution of CBl receptor expression and function in brains of epileptic rats …
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Structural and functional characterization of signaling protein complexes
… Examples from two regulatory proteins, c-Cbl and calmodulin are presented. c-Cbl is an E3 ubiquitin ligase and a major regulator of tyrosine kinases. Through x-ray crystallography of five Cbl-TKB:phosphopeptide complexes, the mechanism by which the Cbl-TKB domain binds to its substrates is …
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A study of the implementation of virtual instrumentation in university laboratory environments
… Previous work utilising Computer Based Learning (CBL) in similar projects relating to this work have been used to evaluate some of the benefits of virtual instrumentation, especially those relating to increased student interest, memory retention, understanding and ultimately performance in …
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Regulation of Syk activity in GPVI-mediated platelet activation
… responses and a prothrombotic phenotype. c-Cbl has been shown to be a negative regulator of GPVI signaling, possibly by regulating Syk phosphorylation. Thus, SHP-1, SHP-2 and TULA-2’s role in c-Cbl regulation of GPVI was also investigated. We show that TULA-2 is able to bind c-Cbl in …
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Study of design tradeoffs of DRAM and SRAM memories, using HSPICE computer simulation
… size as reflected by bit line capacitance (Cbl) were studied as a function of particular design variables: memory cell capacitance (Cc); CMOS flip-flop sense amplifier (SA) transistor sizes; and size of precharge (PC), and word line (WL) switches. Performance was optimized using circuit …
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The development of a multi-function computer-assisted instruction system using a hierarchical database structure as the lesson compendium.
… still remains true that Computer-Based Learning (CBL) is falling significantly short of its potential. Experience of a small, but highly successful CBL system within a large, geographically distributed industry (the National Coal Board) prompted an investigation into currently available packages, …
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THE OBSERVED VARIATION OF COHERENT UPDRAFT OBJECTS WITH HEIGHT IN THE CONVECTIVE BOUNDARY LAYER
… rising through the convective boundary layer (CBL) modulate the flux of heat, moisture, momentum, and aerosols from the surface to aloft. These fluxes also determine the lower boundary conditions for cumulus development (e.g., shallow vs. deep cumuli) provided that thermals and plumes rise to …
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The Interplay of Signal Transduction and Membrane Traffic of the Macrophage Colony Stimulating Factor Receptor (MCSFR) Controls Macrophage Growth
… ubiquitin to the MCSFR by the ubiquitin-ligases Cbl and Cbl-b in the hematopoietic stem cell (HSC) compartment. These mice succumb to lethal myeloproliferative disease by 4 months of age, reminiscent of human juvenile leukemia. By analyzing macrophages from these mice we have shown that Cbl and …
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Fresado biológico vs fresado incremental. Evaluación de los cambios térmicos y comparación Histomormétrica del hueso crestal y del contacto hueso implante. Estudio experimental en perros Beagle
… y con irrigación . Evaluación del BIC y del CBL en implantes colocados con una técnica de fresado biológico vs. fresado convencional en mandíbula de perros, mediante análisis histomorfometrico a 30 y 90 días. Materiales y métodos: Previa autorización y aprobación del comité de ética, se …
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The role of the central bank of Libya in the era of globalisation
… the most applicable prototype for the role of CBL and to evaluate a suitable approach to carry out an effective process that will ensure Libya’s economic growth and integration into the increasingly globalised community. As such, this study contributes extensively into the subject of Libyan …
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Mudança educacional e liderança: criação do curso de ciências biomédicas laboratoriais em Portugal
… em Ciências Biomédicas Laboratoriais (CBL) que conglutina as duas licenciaturas anteriormente referidas. Seis instituições de ensino superior público submeteram a acreditação ciclos de estudos em CBL e todas obtiveram acreditação junto da A3ES. Este trabalho tem como principal …
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Ubiquitination of EpoR and p85 in Ligand Induced EpoR Down-Regulation
… Epo-dependent EpoR internalization. Epo induces Cbl-dependent ubiquitination of the p85, which binds to phosphotyrosines on EpoR. Ubiquitination allows p85 to interact with epsin-1, thereby driving EpoR endocytosis. Knockdown of Cbl, expression of its dominant negative forms, or expression of an …
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Genetic investigation of South Africans with the Noonan Syndrome phenotype using targeted next generation sequencing
… panel of 14 genes, including A2ML1, BRAF, CBL, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, PTPN11, RAF1, RIT1, SHOC2, SOS1 and SPRED1. Results: Of the 26 patients included, 50% had a family history suggestive of NS. The median age at diagnosis was4.5 years (range: 1month-51years). Individuals of …
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