Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"CB2 receptor."”.
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SELECTIVE CB2 RECEPTOR ACTIVATION AMELIORATES INFLAMMATION IN CENTRAL NERVOUS SYSTEM BY REDUCING TH17 CELL DIFFERENTIATION AND IMMUNE CELL ACCUMULATION.
… injury in the CNS. The two most well-defined receptors are the CB1 and CB2 receptors. CB2, the cannabinoid receptor expressed primarily on hematopoietic cells and activated microglia, mediates the immunoregulatory functions of cannabinoids. The involvement of CB2 in central nervous …
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Pain-modulating effects of peripheral (CB2) cannabinoid receptors
Cannabinoid receptor agonists diminish responses to painful stimuli. Extensive evidence implicates the CB1, receptor in the production of antinociception, inflammatory hyperalgesia, and peripheral nerve injury-induced sensory hypersensitivity. In previous work included in my masters thesis, our …
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Central cannabinoid regulation of food intake in chickens
… Following the discovery of two cannabinoid receptors, CB1 and CB2 receptors, it was determined that CB1 receptors are in high density in the central nervous system while CB2 receptors are found primarily in the immune system. The endogenous cannabinoid ligands, anandamide and …
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Design, Synthesis And Cannabinoid Receptor Activity Of Benzofuran Ligands
… through the actions of two g-protein coupled receptors, cannabinoid receptor 1 (cb1) and cannabinoid receptor 2 (cb2). Significant neuronal expression and distribution of cb1 throughout the brain establishes its function as a major synaptic signaling receptor, and in regards to the actions of …
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Role of the Endocannabinoid System in Cardiac Remodeling
The endocannabinoid system and CB1 and CB2 cannabinoid receptors have been implicated in cardiac remodeling with CB1 inhibition and CB2 activation reported to be beneficial. However, the role of these receptors in cardiac remodeling secondary to hypertension is not known. Moreover, the functions of …
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Characterization of Novel CB2 Agonist SMM-295 and Its Effects in Ischemia/Reperfusion Injury
… our efforts to further categorize the effects of CB2 activation, a possible novel therapeutic target in AKI.</p> <p>There is increasing importance associated with the understanding of the biological activity of the cannabinoid receptors following the increased acceptance in the medicinal purposes …
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Il Δ9-THC, componente principale della cannabis sativa, attenua la neurotossicità indotta dalla meth
… Δ9-THC) and synthetic cannabinoid CB1 receptor agonists exert neuroprotective effects in different models of cerebral damage, including excitotoxic injury [Deng X and Cadet JL, 2009; La Voie MJ, et al. 2004]. In this study we evaluated the neuroprotective effect of Δ9-THC on an animal …
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Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation.
… this study demonstrated the presence of both CB receptors on SMCs, LCMS/MS analysis of tissue samples showed that endocannabinoid concentration was significantly (2-arachidonoylglycerol / 2-AG) increased in injured artery sections. Isolated vessel studies demonstrated that AEA produces a small …
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Protein-ligand interaction studies and identification of new drug-like hits as cannabinoid receptor modulators
<p>The cannabinoid receptors (CB1 and CB2) belong to the family of class A GPCRs. The CB1 receptor is predominately found in the central nervous system and regulates various neuromodulatory and physiological processes while CB2 receptors are found in peripheral tissues, particularly in the immune …
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CANNABINOID MODULATION OF HIV-1 TAT-STIMULATED ADHESION OF MACROPHAGE-LIKE CELLS TO THE EXTRACELLULAR MATRIX
… THC and CP55940 that bind through the CB2 receptor which inhibits this adhesion as well as the morphological changes. The modulation of this reorganization is characteristic of a signal transduction pathway where a novel convergent point between extracellular Tat and the select …
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Cannabinoid Receptor 2 (CB2) Ligands Downregulate Pro-Inflammatory Markers in Stimulated Primary Human Periodontal Ligament Fibroblasts (hPDLFs)
… include the cannabinoid type 1 and 2 receptors (CB1R and CB2R). The CB2 receptor is an attractive target in the endocannabinoid system (ECS), due to widespread expression in peripheral tissue, upregulated expression during inflammation and lacks adverse psychotropic effects associated …
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Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid: possible role for endocannabinoids?
… demonstrated the interference of cannabinoid receptor signalling with intracellular uptake and accumulation of DHA, an effect which was demonstrated to be mediated, at least in part, via CB2 receptor signalling. Moreover, the study provided the novel observation that DHA treatment of activated …
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Synthesis of Novel Cannabinoid Ligands and Their Use as Anti-Glioma and Anti-Inflammatory Agents
<p>Following the discovery of the cannabinoid receptors, research in the field of cannabinoids has grown exponentially over the last two decades. Cannabinoids have been shown to have tremendous therapeutic potential in the treatment of several pathological conditions ranging from inflammation to …
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Novel Insights into CB1 Receptor Signaling and the Anabolic Role of Cannabinoid Receptors in Bone
Activation of the CB1 receptor is modulated by aspartate residue D2.63176 in transmembrane helix (TMH) II. Interestingly, D2.63 does not affect the affinity for ligand binding at the CB1 receptor. Studies in class A GPCRs have suggested an ionic interaction between residues of TMHII and VII. In …
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CANNABINOID RECEPTORS (CB) IN COCHLEA: CHARACTERIZATION AND OTOPROTECTIVE FUNCTIONS
… as diacylglycerol lipase-α (DAGL- α), and CB receptors. Primarily, there are three types of CB receptors - CB receptor 1(CB1), CB receptor 2 (CB2) and non CB1 non CB2 types of CB receptor (e.g. GPR, TRPV1) and they belong to G-protein (Gi/o) coupled receptors (GPCR) family.CB1 receptors are …
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Targeting the Endocannabinoid System to Reduce Inflammatory Pain
… predominantly through cannabinoid CB1 and CB2 receptors, but these actions are short-lived because of rapid hydrolysis by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively. Selective inhibition of either enzyme elevates CNS levels of the appropriate …