NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 21 for “"CB1R"”.

  1. THC-MEDIATED INDUCTION OF ΔFOSB AND ITS MODULATION OF CB1R SIGNALING AND ADAPTATION

    Matthew, Lazenka2018

    … mediated through cannabinoid type 1 receptors (CB1Rs). The therapeutic uses of THC are mitigated by the development of tolerance to these therapeutic effects, whereas tolerance does not readily develop to some of the side-effects of THC, like motor impairment and reward. The development of …

    vcu Repository record

  2. Cannabinoid CB1R Receptor Mediates Metabolic Syndrome in Models of Circadian and Glucocorticoid Dysregulation

    Bowles, Nicole

    <p>The most recent projections in the growing obesity rates across the nation show an increase to 60% by the year 2030. These growing rates of obesity are paralleled by an increased rates of depressive conditions, anxiety, and sleep loss, often with environmental factors at the root of the cause. …

    rockefeller Repository record

  3. CANNABINOID RECEPTOR INTERACTING PROTEIN 1A (CRIP1A): EFFECTS ON CB1 RECEPTOR FUNCTION AND CELLULAR REGULATION

    Blume, Lawrence ChristopherWake Forest University2014

    … the United States. The CB1 cannabinoid receptor (CB1R) has been extensively studied since the initial characterization of its involvement in mediating the psychotropic effects of marijuana. CB1R is one of the most abundantly expressed G protein coupled receptors (GPCR) in the CNS and has been …

    wfu Repository record

  4. Synthesis of fluorinated cannabinoid derivatives; Towards PET radiotracers for imaging the cannabinoid receptor

    Orji, Placid NnamdiUniversity of Saskatchewan

    … through the type 1 cannabinoid receptor (CB1R) which is highly expressed in the human brain1,2. Defects in CB1R expression or endocannabinoid transmission have been associated with several neuropsychiatric disorders thus establishing CB1R as a potential drug target or biomarker of …

    sask Repository record

  5. Cannabinoid regulation of excitatory synaptic transmission at hippocampal synapses

    Farah, AdhamUniversity of Dundee2021

    … their biological effects via activation of CB1R and CB2R subtypes (Battista et al., 2012), however in the CNS, the predominant cannabinoid receptor is CB1R. In the hippocampus, varying results have been obtained on the extent and site of cannabinoid-mediated actions on excitatory synaptic …

    dundee Repository record

  6. La signalisation du recepteur cannabinoïde de type-1 et son role dans la regulation de la dynamique du lactate cerebral chez la souris en libre mouvement [Il recettore cannabinoide di tipo 1 nella modulazione delle dinamiche del lattato cerebrale in topi in libero movimento]

    DALLA TOR, TOMMASOUniversità degli studi di Catania2026

    … il recettore dei cannabinoidi di tipo 1 (CB1R) nella regolazione del metabolismo astrocitario. L’attivazione persistente dei CB1R mitocondriali (mtCB1R) negli astrociti per 24 ore è stata associata a una riduzione della produzione di lattato. Al contrario, lavori recenti del nostro …

    catania Repository record

  7. Role of the ventral tegmental area, cannabinoid receptors and GABA neurons in motor activity

    Erik Justin ShankThe University of Texas Medical Branch2006

    … site of action for cannabinoid receptors (CB1R) and provide the first detailed analysis of the distribution of CB1R throughout the various subnuclei and across the rostrocaudal extent of the VTA. We demonstrated that CB1R populations have postsynaptic localization in the VTA, and a …

    utmb Repository record

  8. Cannabinoid CB1 Receptor Expression and Localization in the Dorsal Horn of Male and Female Human and Rat Spinal Cord Tissue

    Parnell, Jessica MarieCarleton University2022

    … expression of the cannabinoid type 1 receptor (CB1R) across dorsal horn laminae and cell populations in male and female adult rats and humans. Qualitatively, we observed increased neuropil immunostaining in the SDH of rats and humans, and somatic staining in deeper laminae. Quantitative results …

    carleton Repository record

  9. Role of the Endocannabinoid System in Behavioral Reactions in a Depressive-Like Condition // Роля на ендоканабиноидната система в поведенчески реакции при депресивно-подобно състояние

    Маринов, Мирослав, Marinov, MiroslavMedical University of Varna2019

    … ролята на селективни агонисти и антагонисти на CB1R върху механизмите на развитие на депресивни разстройства. МЕТОДИ. Върху плъхове с модел на двустранна олфакторна булбектомия (ОВХ) беше изследвано действието на HU 210 – агонист и SR 141716A – антагонист на CB1R, инжектирани …

    varna Repository record

  10. Multifunctional Polymer Fiber Probes for Biomedical Application

    Kim, JongwoonVirginia Tech2024

    … (LFP) while manipulating cannabinoid receptors (CB1R; microfluidic agonist delivery) and CA1 neuronal activity using optogenetics. Focal infusion of CB1R agonist downregulated theta and sharp wave-ripple oscillations (SPW-Rs). Furthermore, we found that CB1R activation reduces sharp wave-ripples …

    vt Repository record

  11. Effect of Cannabinoids and Stress on Motor Maps and Behaviour

    Scullion, KathleenGraduate Studies2015

    … study determined that cannabinoid 1 receptor (CB1R) signaling dampened motor map expression and that both anandamide (AEA) and 2-arachidonoylglycerol (2-AG) contributed to this effect. Activation of CB1R signaling did not affect skilled reaching task performance. However, a lack of cannabinoid …

    calgary Repository record

  12. Effects of alcohol and ∆9-tetrahydrocannabinol on energy balance and cognitive behaviors

    Nelson, Nnamdi G.University of Illinois at Urbana-Champaign2019

    … activates cannabinoid subtype 1 and 2 receptors (CB1R and CB2R) to modulate many behavioral and metabolic processes, including feeding and glucose homeostasis. For several reasons, reports on the long-term effects of alcohol and THC use on energy balance, glucose homeostasis, and cognitive …

    uiuc Repository record

  13. Effect of cannabinoids on pain-stimulated and pain-depressed behavior in rats

    Kwilasz, Andrew2018

    … and acid-depressed ICSS included: mixed CB1R/CB2R agonists THC and CP55940, drugs that modulate levels of the endogenous cannabinoid agonist anandamide (URB597 and PF3845), and a selective CB2R agonist, GW405833. THC was also tested in assays of LPS-stimulated mechanical allodynia and …

    vcu Repository record

  14. Cannabinoids and Psychosis – Cause and Treatment

    Morrison, Paul DKing's College London2012

    … THC stimulates the endocanabinoid CB1 receptor (CB1R). However, beyond CB1Rs, the mechanism underlying the pro-psychotic effects of THC is unknown. <em>The ecploration of candidate mechanisms was the first major theme in this thesis</em>. In Study 1 the pro-psychotic properties of intravenous …

    kings Repository record

  15. Medicinal Chemistry of Cannabis and Cannabinoids

    Yang, Yi2023

    … generated meaningful prediction models for CB1R and CB2R agonism, predicting the cannabinoid receptor activities of individual phytocannabinoids with reasonable accuracy and revealing differences in cannabinoid receptor responses between pure cannabinoids and cannabis extracts. Finally, the …

    toronto-retro Repository record

  16. Estudios de efectos neurobiológicos del Δ9-tetrahidrocannabinol (THC) en modelos animales

    Moreno Paublete, Rocío2012

    … de receptores D3, existiendo interacción entre CB1R y D3R, pues el agonista D3R PIPAT aumenta el efecto motor del THC, pero el antagonista D3R GR103691 es capaz de disminuir el efecto motor del THC. 4) El THC tiene efectos bifásicos sobre la supervivencia de neuronas nígricas, pues ejerce …

    sevilla Repository record

  17. Cannabinoid Receptor 2 (CB2) Ligands Downregulate Pro-Inflammatory Markers in Stimulated Primary Human Periodontal Ligament Fibroblasts (hPDLFs)

    Abidi, Ammaar Hasan2021

    … include the cannabinoid type 1 and 2 receptors (CB1R and CB2R). The CB2 receptor is an attractive target in the endocannabinoid system (ECS), due to widespread expression in peripheral tissue, upregulated expression during inflammation and lacks adverse psychotropic effects associated with CB1 …

    tenn-hsc Repository record

  18. Development and Characterization of Selective CB2R Inverse Agonists as a Novel Anti-Inflammatory Therapy for Neuroinflammation – Mechanisms of Action in Murine and Human Microglia Models Provide Valuable Insights into Their Therapeutic Potential

    Alghamdi, Sahar Saleh2021

    … whereas no functional activity was detected at CB1R. Moreover, testing compound 45 in the TANGO-bla assay revealed neutral antagonism at β-arrestins signaling, confirming the G-protein functional selectivity of this class of compounds. Treatment with compound 45 triggered a shift in murine and …

    tenn-hsc Repository record

  19. Caratterizzazione del clofibrato agonista sintetico dei recettori dei proliferatori dei perossisomi (PPARα)in modelli animali di depressione ed ansia

    MAMELI, ALESSANDRAUniversità degli Studi di Cagliari2015

    … an involvement of PPARα, while, the CB1r antagonist/inverse agonist SR141716A, conversely MK886, did no antagonize the antidepressant-like effect of clofibrate, excluding a possible involvement of the endocannabinoid system. Interestingly, the co-administration of sub-effective dose …

    cagliari Repository record

  20. Purinergic Signalling and Potassium Homeostasis Regulate Somatosensory Adaptation

    Macnab, MadisonUniversity of Saskatchewan2022

    … in a retrograde manner to act on CB1 receptors (CB1R) resulting in the inhibition of neurotransmitter release (Kreitzer & Regehr, 2002; Scheller & Kirchhoff, 2016). Additionally, we applied a solution with low K+ to prevent accumulation of extracellular K+ during sustained firing. Finally, to …

    sask Repository record

Page 1 of 2