Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"CB1 receptor"”.
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Synthesis and Development of Potential CB1 Receptor Neutral Antagonists
… is delta-9-tetrahydrocannabinol. Cannabinoid receptors function to increase activity in the mesolimbic dopamine reward system. Dopamine is a neurotransmitter that plays a major role in addition and its regulation plays a crucial role in mental and physical well-being. There is evidence that …
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Design and Synthesis of CB1 Receptor Ligands and Synthesis of Amphibian Alkaloids
Our project was aimed at the development of novel CB1 cannabinoid receptor antagonists that may have clinical applications for the treatment of cannabinoid and psychostimulant addiction. In this study, we designed, synthesized, and established the CB1 affinity for the 1,5-diaryl-1,2,3- triazole …
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Cell-type specific CB1 receptor modulation of hippocampal synaptic plasticity and memory
… memory and learning mainly via the cannabinoid receptor type 1 (CB1)-dependent regulation of neuronal and glial activity. In the hippocampus, bidirectional communication between neurons and astrocytes shapes synaptic plasticity and behavior. CB1 receptors have been shown to be present in the …
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The role of the CB1 receptor in learning, memory and anxiety-like behaviors
… and anxiety-like behaviors in wild type (CB1+/+) and CB1-receptor-deficient (CB1-/-) mice of differing ages. Differences were observed between CB1+/+ and CB1-/- mice in a Morris Water Maze acquisition task. Furthermore, CB1-/- mice did not display deficits in extinction during reversal …
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The role of the CB1 receptor in learning, memory and anxiety-like behaviors
… and anxiety-like behaviors in wild type (CB1+/+) and CB1-receptor-deficient (CB1-/-) mice of differing ages. Differences were observed between CB1+/+ and CB1-/- mice in a Morris Water Maze acquisition task. Furthermore, CB1-/- mice did not display deficits in extinction during reversal …
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CANNABINOID RECEPTOR INTERACTING PROTEIN 1A (CRIP1A): EFFECTS ON CB1 RECEPTOR FUNCTION AND CELLULAR REGULATION
… used illicit drug in the United States. The CB1 cannabinoid receptor (CB1R) has been extensively studied since the initial characterization of its involvement in mediating the psychotropic effects of marijuana. CB1R is one of the most abundantly expressed G protein coupled receptors (GPCR) in …
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Novel Insights into CB1 Receptor Signaling and the Anabolic Role of Cannabinoid Receptors in Bone
Activation of the CB1 receptor is modulated by aspartate residue D2.63176 in transmembrane helix (TMH) II. Interestingly, D2.63 does not affect the affinity for ligand binding at the CB1 receptor. Studies in class A GPCRs have suggested an ionic interaction between residues of TMHII and VII. In …
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Cannabinoid CB1 Receptor Expression and Localization in the Dorsal Horn of Male and Female Human and Rat Spinal Cord Tissue
… gap in the literature in respect to cannabinoid receptor expression and localization in the spinal cord across both sex and species, with almost nothing known in humans. We used immunohistochemistry and confocal imaging to investigate the differential expression of the cannabinoid type 1 receptor …
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Endocannabinoid Modulation of Spatial Memory in Aversively and Appetitively Motivated Barnes Maze Tasks
… deletion or pharmacological blockade of the CB1 receptor has been reported to impair extinction learning in aversive conditioning (i.e., conditioned fear and Morris water maze) paradigms, but not in operant procedures in which food reinforcement is earned. It is difficult to discern whether …
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Functional Characterization of CRIP1a Knockout Mice
CB1 cannabinoid receptors are G-protein-coupled receptors that mediate the central nervous system (CNS) effects of marijuana and endocannabinoids. Recently, cannabinoid receptor interacting protein 1a (CRIP1a) was discovered as a novel protein that binds to the CB1 receptor C-terminus and inhibits …
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A Systematic Investigation of Whether Cannabinoids and Opioids Interact in the Nucleus Accumbens Shell to Differentially Impact Feeding Patterns on a Palatable Diet
… food by determining whether blockade of CB1 receptors modulated mu-opioid stimulated feeding, and whether blockade of mu-opioid receptors impacted CB1 stimulated feeding. Additionally, these experiments sought to investigate whether co-administering opioid and cannabinoid agonists into …
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Design, Synthesis and Biological Evaluation of Novel Cannabinoid Antagonist
… study was aimed at the development of novel CB1 cannabinoid receptor antagonists that may have clinical applications for the treatment of cannabinoid and psychostimulant addiction. The rationale for the design for our target was to incorporate a bioisosteric 1,2,3-triazole ring into the …
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Distribution and function of TRP ion channels in primary sensory neurons
… effects via activation of the cannabinoid CB1 receptor located on TRPV1-expressing primary sensory nerve fibres in peripheral tissues. However, we find no evidence of CB1 receptor immunoreactivity on nerve fibres in rat or mouse hindpaw skin and mesenteric artery. The CB1 receptor agonists …
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Novel roles of the endocannabinoid system in modulating synaptic plasticity
… investigated the roles of eCBs and their primary receptor, the CB1 receptor, in the central nervous system using electrophysiological recordings in rodent hippocampus. We find that a moderate frequency 10 Hz stimulation protocol produces long-term potentiation (LTP) that is modulated by eCBs in …
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Novel roles of the endocannabinoid system in modulating synaptic plasticity
… investigated the roles of eCBs and their primary receptor, the CB1 receptor, in the central nervous system using electrophysiological recordings in rodent hippocampus. We find that a moderate frequency 10 Hz stimulation protocol produces long-term potentiation (LTP) that is modulated by eCBs in …
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The Role of MAGL Inhibition in Nicotine Withdrawal and Reward
… effects were blocked by rimonabant indicating a CB1 receptor mechanism. Furthermore, repeated administration of JZL184 for 6 days did not produce tolerance to the alleviation of withdrawal and the treatment did not induce alterations in CB1 receptor levels or receptor-mediated G-protein activity …
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Ruolo del recettore CB1 cellulare e sub-cellulare in cellule D1-positive dell'Ippocampo nei Processi della Memoria
… modulation of neuronal activity by cannabinoid receptor type-1 (CB1), the endocannabinoid system represents a major brain modulatory system controlling memory functions. On the other hand, several reports point out a crucial role of hippocampal dopamine signaling in the regulation of memory …
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Characterization and development of a stroke-induced model of acquired epilepsy in organotypic hippocampal slice cultures: role of the cannabinoid CB1 receptors in modulation of neuronal excitation and inhibition
… in distribution and function of the endogenous CB1 receptor system. We utilized 4-aminopyridine and glutamate to induce separate excitotoxic injuries to slice cultures. Both injuries produced significant cell death acutely following the injury. After a latency period, we observed a significant …
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Effetto nell’auto-somministrazione dell’agonista sintetico del recettore cannabinoide CB1, WIN 55,212-2, nel modello animale di depressione della bulbectomia olfattoria (OBX)
… higher voluntary intake of the cannabinoid CB1 receptor agonist WIN 55,212-2 (WIN, 12.5 μg/kg/infusion). The olfactory-bulbectomized rat is a well-established model that exhibits a high degree of behavioural and neurochemical similarity to depression. Male Lister Hooded rats were either …
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Characterization of Rimonabant effects on G protein activity
G protein-coupled receptor (GPCRs) is the largest class of cell-surface receptors, and represents today the target of 40% of the drugs in the pharmaceutical market. In the absence of agonists, many GPCRs have found to exhibit spontaneous activity, which can be blocked by ligands that are referred …
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