Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"CB1 cannabinoid receptor"”.
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Effect Of CBD On D2 Dopamine Receptor And CB1 Cannabinoid Receptor Function And Localization
<p>Cannabidiol (CBD) is the second most abundant cannabinoid found in Cannabis sativa and its array of therapeutic effects make it a popular target of pharmacological research. Though its properties are psychoactive in nature, abuse and dependence of CBD has never been reported. Its beneficial side …
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Design and Synthesis of CB1 Receptor Ligands and Synthesis of Amphibian Alkaloids
Our project was aimed at the development of novel CB1 cannabinoid receptor antagonists that may have clinical applications for the treatment of cannabinoid and psychostimulant addiction. In this study, we designed, synthesized, and established the CB1 affinity for the 1,5-diaryl-1,2,3- triazole …
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CANNABINOID RECEPTOR INTERACTING PROTEIN 1A (CRIP1A): EFFECTS ON CB1 RECEPTOR FUNCTION AND CELLULAR REGULATION
… used illicit drug in the United States. The CB1 cannabinoid receptor (CB1R) has been extensively studied since the initial characterization of its involvement in mediating the psychotropic effects of marijuana. CB1R is one of the most abundantly expressed G protein coupled receptors (GPCR) in …
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Renal Cannabinoid Receptor Expression and Function: Their Role in Obesity and Diabetes
… and diabetic associated renal damage. The endocannabinoid system is an important endogenous lipid signalling system known to mediate glucose and lipid metabolism, inflammation and energy storage. Specifically, diabetes mellitus and obesity induces alterations in the expression of cannabinoid …
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Design, Synthesis and Biological Evaluation of Novel Cannabinoid Antagonist
… study was aimed at the development of novel CB1 cannabinoid receptor antagonists that may have clinical applications for the treatment of cannabinoid and psychostimulant addiction. The rationale for the design for our target was to incorporate a bioisosteric 1,2,3-triazole ring into the …
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Pharmacological modulation of learning and memory in mice and zebrafish: Implications for Alzheimer’s disease animal models
… to be used for cognitive enhancement is CB1 cannabinoid receptor antagonist. CB1 cannabinoid receptor antagonists have been shown to improve learning and memory in rodents, whereas CB1 cannabinoid receptor agonists have been shown to impair memory. The project has overall aims of (1) …
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Die Wirkung von Cannabinoiden auf das Herz-Kreislauf-System und die Atmung von Ratten
… die systemischen und zentralen Wirkungen von Cannabinoiden auf das Herz-Kreislauf-System und die Atemfunktion sind ungeklärt. In der vorliegenden Arbeit wurden drei Fragestellungen untersucht. <br>Erstens sollten zentrale respiratorische und kardiovaskuläre Effekte von Cannabinoiden an …