Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 102 for “"CB1"”.
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HISTAMINERGIC H3 AND CANNABINOID CB1 RECEPTORS IN DEMENTIA
… roles of Histaminergic H3 and Cannabinoid CB1 receptors in neurodegenerative diseases. Based on neurochemical investigations in postmortem human brain samples, the status of H3 receptors remain unchanged under vascular dementia or mixed dementia pathology, and may serve as a therapeutic …
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Synthesis and Development of Potential CB1 Receptor Neutral Antagonists
<p>Cannabis and its derivatives have been used for both medicinal and recreational purposes. The study of this plant led to the discovery of over 60 cannabinoids, found exclusively in cannabis, that contribute to the behavioral effects of cannabis use, the most common is …
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Relationship Between CB1 and S1P Receptors in the Central Nervous System
… anatomical co-distribution between cannabinoid (CB1) and sphingosine-1-phosphate (S1P) receptors in the CNS, but potential functional relationships between these lysolipid receptors have not been examined. Therefore, to investigate possible relationships between these two systems at the level of …
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Design and Synthesis of CB1 Receptor Ligands and Synthesis of Amphibian Alkaloids
Our project was aimed at the development of novel CB1 cannabinoid receptor antagonists that may have clinical applications for the treatment of cannabinoid and psychostimulant addiction. In this study, we designed, synthesized, and established the CB1 affinity for the 1,5-diaryl-1,2,3- triazole …
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Cell-type specific CB1 receptor modulation of hippocampal synaptic plasticity and memory
… mainly via the cannabinoid receptor type 1 (CB1)-dependent regulation of neuronal and glial activity. In the hippocampus, bidirectional communication between neurons and astrocytes shapes synaptic plasticity and behavior. CB1 receptors have been shown to be present in the astrocytes and to …
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The role of the CB1 receptor in learning, memory and anxiety-like behaviors
… and anxiety-like behaviors in wild type (CB1+/+) and CB1-receptor-deficient (CB1-/-) mice of differing ages. Differences were observed between CB1+/+ and CB1-/- mice in a Morris Water Maze acquisition task. Furthermore, CB1-/- mice did not display deficits in extinction during reversal …
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The role of the CB1 receptor in learning, memory and anxiety-like behaviors
… and anxiety-like behaviors in wild type (CB1+/+) and CB1-receptor-deficient (CB1-/-) mice of differing ages. Differences were observed between CB1+/+ and CB1-/- mice in a Morris Water Maze acquisition task. Furthermore, CB1-/- mice did not display deficits in extinction during reversal …
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CANNABINOID RECEPTOR INTERACTING PROTEIN 1A (CRIP1A): EFFECTS ON CB1 RECEPTOR FUNCTION AND CELLULAR REGULATION
… used illicit drug in the United States. The CB1 cannabinoid receptor (CB1R) has been extensively studied since the initial characterization of its involvement in mediating the psychotropic effects of marijuana. CB1R is one of the most abundantly expressed G protein coupled receptors (GPCR) in …
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Effect Of CBD On D2 Dopamine Receptor And CB1 Cannabinoid Receptor Function And Localization
… as an antagonist at cannabinoid receptor 1 (CB1). However, recent evidence suggests that CBD may also be a CB1 negative allosteric modulator of (−)-trans-Δ9-tetrahydrocannabinol (Δ9-THC). Interestingly, the ECS is linked to the main circuit thought to modulate reward signaling when taking …
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Novel Insights into CB1 Receptor Signaling and the Anabolic Role of Cannabinoid Receptors in Bone
Activation of the CB1 receptor is modulated by aspartate residue D2.63176 in transmembrane helix (TMH) II. Interestingly, D2.63 does not affect the affinity for ligand binding at the CB1 receptor. Studies in class A GPCRs have suggested an ionic interaction between residues of TMHII and VII. In …
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The Influence of Sustained CB1 Blockade During Adolescence on Breakpoints in a Progressive-ratio Paradigm
The developmental psychopharmacology of cannabinoids is poorly understood and little is known about the developmental consequences of repeated exposure to cannabinoid antagonists. In these experiments, male Long-Evans rats were treated with SR141716A, a cannabinoid antagonist, throughout …
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Functional Redistribution of Hippocampal Cannabinoid Cb1 Receptors in the Rat Pilocarpine Model of Acquired Epilepsy
Cannabinoids, such as the marijuana derivative Δ9-THC, are known to have CBl receptor-mediated anticonvulsant effects in several animal models of seizures and epilepsy, including the rat pilocarpine model of acquired epilepsy. However, the distribution of CBl receptor expression and function in …
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Eficacia antiparkinsoniana de ligandos cannabinoides del receptor CB1 en un modelo animal de la enfermedad de Parkinson
… los antagonistas cannabinoides del receptor CB1 los fármacos útiles para el tratamiento del Parkinson, ya que la inyección intraestriatal de anandamida en ratas disminuye la síntesis de dopamina por las neuronas dopaminérgicas nigroestriatales. Se ha comprobado la eficacia de antagonistas …
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Ruolo del recettore CB1 cellulare e sub-cellulare in cellule D1-positive dell'Ippocampo nei Processi della Memoria
… activity by cannabinoid receptor type-1 (CB1), the endocannabinoid system represents a major brain modulatory system controlling memory functions. On the other hand, several reports point out a crucial role of hippocampal dopamine signaling in the regulation of memory related processes. …
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Modulation der neokortikalen Neurotransmission durch exogene und endogene Cannabinoide unter Berücksichtigung möglicher Speziesunterschiede zwischen Mensch und Tier
… erster Linie durch Aktivierung von Cannabinoid CB1 Rezeptoren (CB1-R). Körpereigene Liganden sind die sog. Endocannabinoide (EC), denen man Bedeutung als (patho)-physiologische Neuromodulatoren beimisst. Die Manipulation des "EC-Systems" bietet einerseits therapeutische Möglichkeiten, kann aber …
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Cannabinoid CB1 Receptor Expression and Localization in the Dorsal Horn of Male and Female Human and Rat Spinal Cord Tissue
… expression of the cannabinoid type 1 receptor (CB1R) across dorsal horn laminae and cell populations in male and female adult rats and humans. Qualitatively, we observed increased neuropil immunostaining in the SDH of rats and humans, and somatic staining in deeper laminae. Quantitative results …
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Protein-ligand interaction studies and identification of new drug-like hits as cannabinoid receptor modulators
<p>The cannabinoid receptors (CB1 and CB2) belong to the family of class A GPCRs. The CB1 receptor is predominately found in the central nervous system and regulates various neuromodulatory and physiological processes while CB2 receptors are found in peripheral tissues, particularly in the immune …
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Functional Characterization of CRIP1a Knockout Mice
CB1 cannabinoid receptors are G-protein-coupled receptors that mediate the central nervous system (CNS) effects of marijuana and endocannabinoids. Recently, cannabinoid receptor interacting protein 1a (CRIP1a) was discovered as a novel protein that binds to the CB1 receptor C-terminus and inhibits …
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Role of the Endocannabinoid System in Cardiac Remodeling
The endocannabinoid system and CB1 and CB2 cannabinoid receptors have been implicated in cardiac remodeling with CB1 inhibition and CB2 activation reported to be beneficial. However, the role of these receptors in cardiac remodeling secondary to hypertension is not known. Moreover, the functions of …
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