Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"CASR"”.
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CALCIUM SENSING RECEPTOR FUNCTION IN COLON: A ROBUST PROMOTER OF DIFFERENTIATION AND TUMOR SUPPRESSOR
The expression of calcium sensing receptor (CaSR) in the human colonic crypt epithelium is linked to cellular differentiation while its lack of expression is associated with undifferentiated and invasive colon carcinoma. Recent studies show that CaSR suppresses the malignant phenotype through a …
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Modulation Of Renin Secretion By Renal Cortical Interstitial Calcium
… decreases PRA. The calcium-sensing receptor (CaSR) is a ubiquitously expressed receptor that translates changes in plasma calcium into changes in intracellular signaling. JG cells are basolaterally bordered by the renal cortical interstitium, and parathyroid hormone (PTH) positively regulates …
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Vagal Integration of Cardiopulmonary Regulation
… and iii) loss of the calcium-sensing receptor (CaSR) on quasi-static SAR signaling. Expression of CaSR is reported in murine NEBs and implicated in asthma pathogenesis. Loss of CaSR increased NEB size and proliferative markers (immunohistochemical staining); however, we found no evidence for …
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The effect of bone anabolic stimuli on human osteoblast to osteocyte transition.
… of the extracellular calcium sensing receptor (CaSR), NPS2390, as we hypothesised that these cells would ‘sense’ extracellular calcium through this receptor. NHBC tolerated even the highest concentration of Ca²⁺ used. Treatment with Ca²⁺ resulted in a striking dose- and time-dependent increase …
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Estudio de la variabilidad genética en la respuesta al tratamiento con Cinacalcet en pacientes con hemodiálisis.
… (CYP p450) y la farmacodinamia del fármaco (CASR, VDR y GC) podrían ser causa de la variabilidad en la respuesta a tratamiento con cinacalcet, en pacientes sometidos a hemodiálisis. Objetivo: determinar si en hemodiálisis los diferentes polimorfismos de los genes CASR (rs1501899, rs1042636, …
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Receptor-dependent phagocytosis of <i>Clostridium sordellii</i> by human decidual macrophages
… human DMs utilize class A scavenger receptors (CASRs) to internalize unopsonized C. sordellii. In vitro phagocytosis assays with human DMs incubated with pharmacological inhibitors of CASRs (fucoidan, polyinosinic acid, and dextran sulfate) revealed a role for these receptors in <em>C. …
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Exploring the function and sensing mechanisms of human enteroendocrine cells using intestinal organoids
… receptors, such as FFAR1, GPR142 and CaSR. Glucose induced a 1.8-fold increase in GIP secretion compared to glucose-free conditions. This effect was hampered by SGLT1/2 inhibitor sotagliflozin, as well as by knock-out of SGLT1 in the GIP-Venus human organoid line, indicating that this …
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Die Rolle der Umamirezeptoruntereinheit Tas1r1 jenseits ihrer gustatorischen Bedeutung
… Effekte durch den Aminosäuresensor CaSR oder den Peptidsensor Gpr93 war nicht nachweisbar. Es bleibt offen, ob andere Mechanismen oder andere Chemosensoren an einer Kompensation beteiligt sind oder aber Tas1r1 in extraoralem Gewebe andere Funktionen als die der Aminosäuredetektion …
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Search for molecular and metabolic mechanisms contributing to impaired β-cell function
… on the genes Insig1, Lss, Peci, Idi1, Hmgcs1 and Casr were found to be altered in a manner consistent with gene expression. This suggests the involvement of epigenetic regulations. In conclusion, this thesis suggests that the coupling between glycolytic and mitochondrial flux is essential for the …
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Cambios epigenéticos, génicos y de expresión proteica en el cáncer de laringe. Análisis del segmento cromosómico 9P21
… con mayor frecuencia son las ganancias en CASR, CDKN1B, APC, CDK6, TNRSF1A, TNFRSF7 y las pérdidas en VHL, RASSF1, CDKN2B, RARB, MLH3, BCL2, CDKN2A y ESR1. Las pérdidas génicas en 9p21 son frecuentes y condicionan menor supervivencia libre de segundo tumor primario, predominando las de p16 …