Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"CASP4"”.
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Inflammasome upregulation and activation in photoreceptors of type 2 diabetes and N-methyl-N-nitrosourea models is attenuated by Wedelolactone
… canonical (CASP1) and non-canonical pathways (CASP4/11). Oxidative stress plays an important role in vascular and neurodegenerative changes in DR and has been shown to induce mitochondrial dysfunction in various retinal cells where it can manifest as loss of organelle membrane integrity and …
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Entamoeba histolytica-induced Activation of Caspase-4 Regulates Gasdermin D Cleavage to Mediate IL-1β Secretion in Macrophages
… cytokine release, CRISPR-Cas9 gene editing of CASP4/1, ASC, NLRP3, GSDMD THP-1 cells were utilized. In the absence of caspase-1, caspase-4 activation was significantly upregulated and enhanced GSDMD pore formation to trigger robust IL-1β secretion as quantified by HEK-BlueTM reporter cell. The …
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The role of IFN-γ in cell-autonomous immune responses against Salmonella Typhimurium and Toxoplasma gondii
The research presented in this thesis investigates the function of interferon gamma in vacuoles, namely Salmonella enterica serovar Typhimurium and Toxoplasma gondii. IFN-γ is a cytokine that functions in both the innate and the adaptive immune responses. IFN-γ is mainly secreted by T cells and …
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Differential proteomic profiling towards elucidation of TB-IRIS pathogenesis
… stress and overactivation (including via NLRC4, CASP4/5, TLR/IL-1R-MyD88-NFκB, and MAPK-AP1 signalling), producing - instead of Mtb clearance - inflammatory cell death with release of immune-activating and tissue-damaging host- and Mtb-derived molecules. Reactivation of Mtb lymphocyte memory …