Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"CARM1"”.
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Characterizing The Recognition Motif and Novel Substrates of Carm1
… associated arginine methyltransferase 1 (CARM1) and PRMT9. The OPAL platform can also be used to gauge the subtle changes in substrate specificities due to mutations in the enzymes, which may be important in pathologies. In parallel, we show that an OPAL platform with a fixed …
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Developing and Using Methyl-Specific Antibodies to Study The Biological Roles of Arginine Methylation
… arginine methyltransferase (CARM1), functions as a regulator of transcription and splicing by methylating a diverse array of substrates. In order to broaden our understanding of CARM1’s mechanistic actions, we generated CARM1 substrate motif antibodies, and used …
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The role of polarisation in the first cell fate decision of the mouse embryo
… low activity of the arginine methyltransferase CARM1 prior to polarisation are known to be biased towards TE, and inhibition of CARM1, or overexpression of its substrate BAF155, increases the frequency of early polarisation. Thus, this study proposes that early heterogeneities influence cell …
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Discovery and Characterization of Methylation of Arginine 42 on Histone H3: A Novel Histone Modification with Positive Transcriptional Effects
… the DNA backbone. I show that methyltransferases CARM1 and PRMT6 methylate this residue in vitro and in vivo. Using chemically-defined "designer" histones I also show that methylation of H3R42 stimulates transcription in vitro from chromatinized templates. Using peptide pull down experiments …
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Identifizierung und Charakterisierung von Histonmethyltransferasen in Drosophila melanogaster
… identifiziert werden, die den Säugerproteinen CARM1, PRMT1 und PRMT3 homolog sind. Die cDNAs wurden klo-niert und die rekombinanten Proteine biochemisch charakterisiert. Während dieser Arbeit wurden von anderen Gruppen mehrere lysinspezifische Histon-methyltransferasen mit dem katalytisch …