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Showing 1 to 2 of 2 for “"CARF effector"”.
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Investigation of Diverse CARF Effectors in Type III CRISPR - Cas Immunity
… been characterized to date. They often contain a CARF domain to sense cOA and an additional effector domain. Binding of cOA leads to a conformational change in the effector domain, which then provides immunity on a community level by inducing a growth arrest of individual infected cells. In my …
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Uncovering New Mechanisms of Type III CRISPR-Cas System Inhibition and Effector Function
… III CRISPR system which contains a multi-protein effector complex that functions together with its crRNA in target binding and cleavage. During type III CRISPR-Cas immunity in prokaryotes, RNA-guided recognition of viral (phage) transcripts stimulates the Cas10 complex to convert ATP into cyclic …