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Showing 1 to 3 of 3 for “"CARF domain"”.
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Identification and Characterization of Novel CRISPR-Cas Immune Effectors
… via the catalytic activity of the HD domain within the Cas10 protein. Second, and exclusive to type III CRISPR, is the synthesis of cyclic oligoadenylate molecules (cOAs) of various sizes from ATP substrates by the catalytic activity of the palm domain. cOAs go on to activate …
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Investigation of Diverse CARF Effectors in Type III CRISPR - Cas Immunity
<p>All domains of life can be infected by viruses. The simplest forms of life, bacteria, are outnumbered by their viruses, called bacteriophage or phage, by 10 to 1. It is estimated there are more phages on Earth than stars in the sky. Phage act as parasites to bacteria by ejecting their DNA into …
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Accessory Nucleases Provide Robust Antiparasite Immunity for Type III CRISPR-Cas Systems
… it was recently discovered that the Palm domain of Cas10 can synthesise cyclic oligoadenylate second messengers (cA). cA can activate Csm6 by binding to the latter's CARF domain. In this work, I first elucidate and illuminate the role and mechanism of action of Csm6 during anti-plasmid …