Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"CARF"”.
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Investigation of Diverse CARF Effectors in Type III CRISPR - Cas Immunity
… been characterized to date. They often contain a CARF domain to sense cOA and an additional effector domain. Binding of cOA leads to a conformational change in the effector domain, which then provides immunity on a community level by inducing a growth arrest of individual infected cells. In my …
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Identification and Characterization of Novel CRISPR-Cas Immune Effectors
… protein domain among these effectors is the CARF domain. This protein domain is responsible for receiving the cOA signals that Cas10- Csm makes upon sensing an infection in the cell. In my doctoral studies I have studied three proteins containing CARF domains fused to various other domains …
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Accessory Nucleases Provide Robust Antiparasite Immunity for Type III CRISPR-Cas Systems
… cA can activate Csm6 by binding to the latter's CARF domain. In this work, I first elucidate and illuminate the role and mechanism of action of Csm6 during anti-plasmid immunity in staphylococci. I show that Csm6 is required for efficient immunity against a weakly transcribed target but is …
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Uncovering New Mechanisms of Type III CRISPR-Cas System Inhibition and Effector Function
… that bind to CRISPR-associated Rossmann Fold (CARF) proteins and activate their effector domains. The effector part unleashes various activities that are toxic to the host cell, inhibiting cell growth and leading to growth arrest. We are now beginning to uncover that CARF effectors use a wide …
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Mechanisms of Specificity in Neuronal Activity-regulated Gene Transcription
… that neurons lacking the transcription factor CaRF showed enhanced NMDAR-induced expression of Bdnf and Arc both in cultured neurons and following sensory stimulation in the developing brain in vivo. I identified GluN3A as a regulatory target of CaRF and found that neurons lacking GluN3A showed …
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Implementing the WeeFIM System in Outpatient Pediatric Rehabilitation
… of Accreditation of Rehabilitation Facilities (CARF) requires that applicants demonstrate outcome measure data over a 6 month time period. During the self-evaluation process this was noted to be a deficiency in the department’s efforts. The WeeFIM system was chosen as the first tool to implement …
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The WASI as a Screening Tool for Counselors in the Referral Decision for a Neuropsychological Evaluation
… 2001 and 2004 on 73 CD-diagnosed adults at a CARF accredited rehabilitation facility. Disability severity ratings of mild, moderate, and severe were assigned based on clinical judgment and interrater agreement. The assessment battery included the WASI and several neuropsychological tests: …
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Caracterização de seqüências expressas do genoma café potencialmente relacionadas com a resistência a doenças
… e susceptíveis. Esse marcador, denominado CARF 005, amplifica uma região do DNA que corresponde a uma ORF parcial de Coffea arabica que codifica uma proteína de resistência a doenças.