Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"CAR-T therapy"”.
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TOX2 and TOX at the intersection of central memory and exhaustion in human CAR T cells
CAR T therapy has provided a breakthrough in the treatment of hematologic malignancies, showing remarkable efficacy in cancers such as leukemia and lymphoma. However, the success of CAR T therapy in treating solid tumors has been limited due to T cell exhaustion, which limits their proliferation …
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Utilizing in vivo genome-wide CRISPR/Cas9 screens in immunocompetent mouse models to identify novel tumor liabilities and explore mechanisms of resistance to Chimeric Antigen Receptor T-cell therapy
… (GBM) where most patients, even with standard of care treatment, are dead within 1 year of diagnosis. This lack of effective treatment for GBM reflects formidable challenges to therapeutic design including vast intra- and inter-tumoral heterogeneity, highly invasive growth patterns, and a hostile, …
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Efficacy of Dual Cd19-Cd79B Car In B-Cell Malignancies
… CD19-targeting chimeric antigen receptor (CAR) T cell therapy. CD19 loss is a major cause of relapse and resistance after CD19 CAR T therapy. Dual antigen targeting could overcome resistance due to antigen escape and improve outcomes after CAR T cell therapy. We hypothesized that dual …
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Study of altered metabolism in cancer by high content SRS microscopy
… identify and target metabolic pathways in cancer therapy contexts.In the first project, I applied high-content SRS imaging to study metabolic changes in ovarian cancer cells surviving the CAR-T challenge. CAR-T therapy shows promise in liquid tumors but faces significant challenges in solid tumors …
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Exploring Veto Activity: DNAM-1-CD155 Axis in Overcoming NK Cell-Mediated Allo-Rejection and Applications for CAR-T Cell Therapy
… of Off-the- shelf Chimeric Antigen Receptor (CAR)-T Therapy: Engineering Anti-Viral Veto CD8+ T Cells”. As demonstrated in our previous research, in a murine model with mild conditioning, anti-third-party central memory CD8+ veto T cells (veto Tcm) can prevent T cell- mediated graft rejection …
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Cell-Free Dna Sequencing In Multiple Myeloma
… plasma cell dyscrasia. Recent advances in MM therapy, including CAR-T therapy, have increased survival and shown the value of assessing treatment response with great sensitivity, both in acute and long-term settings. Cell-free DNA, DNA fragments which are released into circulation as a part of …
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Engineered Type 1 Conventional Dendritic Cell–Based Therapies for In Situ Cancer Immunization
Cancer immunotherapy, such as immune checkpoint inhibitors, Chimeric Antigen Receptor (CAR) T therapy, and cytokine therapy, have achieved successful improvement in extending survival in some patients. However, the immunosuppressive environment of solid tumors substantially compromises therapeutic …
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Investigation of the anticancer activity and mechanisms of zinc diethyldithiocarbamate in multiple myeloma
… drugs (IMiDs), proteasome inhibitors (PI), CAR-T therapy and antibody-based therapies have improved the prognosis of MM, all patients eventually relapse due to the presence and development of drug resistance. Therefore, the development of new drugs to meet this challenge is of clinical …