Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"CAMKK2"”.
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Characterisation of calcium/calmodulin-dependent protein kinase kinase 2 in prostate cancer
CaMKK2 is an enzyme which has been implicated in PCa tumorigenesis and progression by the regulation of glycolysis through activation of its substrate AMPK. However phenotypic effects observed in CaMKK2 KO mice and cell lines with CaMKK2 inhibition or silencing were not rescued by AMPK, suggesting …
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Regulation of Systemic and Cellular Metabolism In Prostate Cancer By Camkk2 and Elucidation of Atgl’S Role In Disease Progression
… of prostate cancer. A direct target of AR is <em>CAMKK2</em>, a gene coding for the serine/threonine kinase Ca<sup>2+/</sup>calmodulin-dependent protein kinase kinase 2 (CAMKK2), a protein upregulated in advanced prostate cancer. CAMKK2 modulates many of its pathological effects through the …
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Identification and Targeting of Downstream Ar-Camkk2-Mediated Mechanisms For The Treatment of Advanced Prostate Cancer
… protein kinase kinase 2 (CAMKK2) was identified as an essential downstream component of AR signaling in prostate cancer that correspondingly tracked with disease progression. While the importance of CAMKK2 in AR-mediated prostate cancer progression has been established, our …
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Identification of Novel Regulators in Hematopoiesis: Roles for Gfer in Hematopoietic Stem Cell Proliferation and CaMKK2 in the Restriction of Granulopoiesis
… work describes our studies of a CaMKIV kinase, CaMKK2, and its role in HSCs and hematopoietic development. These studies were largely based on the usage of mice genetically ablated for the <i>Camkk2</i> gene in the germline. Herein, we identified a role for CaMKK2 in the restriction of …
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Leveraging Protein Homeostasis as a Disease-modifying Strategy
… and apply it toward a proposed AD PPS target CAMKK2. Together, our findings contribute to a deeper understanding of how proteostasis proteins are involved in disease mechanisms, laying the groundwork for the development of therapeutic strategies aimed at restoring proteostasis as a means of …
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The Transcription Factor TFEB Protects Against Cardiac Hypertrophy by Increasing Lysosomal Capacity and Activating AMPKα
… conditions. This occurs in a manner dependent on Camkk2 activity. Based on these data, we conclude that TFEB antagonizes pathological, hypertrophic cardiac remodeling through up-regulation of lysosomal capacity and AMPK signaling. Ins light of recent effort in developing TFEB agonists, our study …
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A Molecular and In Vivo Investigation of Advanced Prostate Cancer: Deconstructing Ampk Activity and Developing An Improved Mouse Model
… calcium/calmodulin-dependent kinase kinase 2 (CaMKK2) is a direct downstream target of AR, and can promote disease progression through the phosphorylation and activation of the 5’ AMP activated protein kinase (AMPK). AMPK is a major regulator of cell homeostasis. While it is well established …