Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"CALR"”.
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New molecular and cellular aspects of mutant calreticulin in Myeloproliferative Neoplasms
Calreticulin (CALR) is an endoplasmic reticulum (ER) protein that plays an important role as a calcium (Ca2+) buffering chaperone. Mutations in CALR exon 9 have been identified in essential thrombocythemia and primary myelofibrosis, two myeloproliferative neoplasms (MPNs) characterised by …
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Caracterização clínica e molecular de pacientes com neoplasia mieloproliferativa crônica- cromossomo Ph- negativo
… para receptor da trombopoetina (MPL) e no gene calreticulina (CALR). Ainda que a caracterização molecular desses pacientes seja uma ferramenta diagnóstica imprescindível, permanece sob estudo as implicações que essas alterações causam no fenótipo da doença. Neste trabalho realizamos a …
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Detection of the calreticulin type 1 and type 2 mutations in a group of myeloproliferative neoplasm patients using molecular methods
… (MF). In 2013, somatic mutations at exon 9 of CALR, the gene that encodes for calreticulin, were discovered through whole-exome sequencing and targeted re-sequencing in patients with MPNs. Among these mutations, more than 80% of CALR mutated patients possessed one of only two mutation types: …
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Investigating the anti-leukaemic effect of tamoxifen in the myeloproliferative neoplasms
… or the multi-functional protein CALR (such as CALR<sup>Ins5</sup> and CALR<sup>Del52</sup>), causing the constitutive activation of signal transducer and activator of transcription (STAT) proteins. The selective oestrogen receptor modulator (SERM) tamoxifen (broadly used in ER+ …
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Elucidating the role of Mitoferrin (Mfrn), Iron Regulatory Proteins (IRP1 and IRP2) and Hephaestin (Heph) in Iron Metabolism by tagSNP and Protein-Protein Interaction (PPI) analysis
… analysis identified the excised band as Calreticulin (CALR). This is the first report of calreticulin having ferroxidase activity.
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Molecular Mechanisms of Itch Sensations
… and Itpr3), three histamine-dependent: S100a8, CALR and DSP) and one both-dependent: TRPV4) itch genes. Atp2a1 and Itpr3 were selected for further characterization. Atp2a1 and Itpr3 are involved in GRPR downstream Ca2+ signaling pathway for histamine-independent itch. GRPR is also expressed in …
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Determinants of clinical phenotype in myeloproliferative neoplasms
… in at least 5 patients, with mutations in JAK2, CALR, or MPL being the sole abnormality in 45% of the patients. The numbers of driver mutations increased with age and advanced disease. Driver mutations, germline polymorphisms, and demographic variables independently predicted whether patients …
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Cytokine receptor-like factor 3 (CRLF3): A novel regulator of platelet biogenesis and potential drug target for thrombocythaemia
… mutations in mainly Janus Kinas 2 $(JAK2)$, CALR and MPL cause essential thrombocythaemia $(ET)$. ET is a rare disease that leads to an increased risk of cardiovascular thrombotic events. Current treatment of ET uses combination of low dose aspirin to decrease platelet function and …