Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 98 for “"CAG"”.
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CAG repeat expansions induce cytoplasmic RNA aggregation
Expansions of ‘CAG’ trinucleotide repeats in the genome can cause over a dozen diseases, including Huntington disease and several spinocerebellar ataxias. Short tracts of these ‘CAG’ repeats are benign; however, mutant alleles that harbor an abnormally large number of consecutive ‘CAG’ motifs can …
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Nachweis und genetische Analyse der cag Pathogenitätsinsel von Helicobacter pylori mit neuen, molekularbiologischen Methoden
Die cag-PAI ist ein wichtiger Virulenzfaktor von H. pylori und mit schwereren <br>Krankheitsverläufen der H. pylori-Infektion wie Magenulkus- und Malignombildung <br>assoziiert. Im Rahmen dieser Arbeit wurden zwei diagnostische Methoden zur Analyse der cag-PAI von H. pylori etabliert. Dabei konnte …
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Functional characterisation of the CAG polymorphism in the androgen receptor- in vitro and in vivo
… In the AR coding region there is a polymorphic CAG repeat encoding a stretch of the amino acid glutamine (Q). The repeat length modulates receptor activity and is normally distributed between 10-30 CAG with a median length of 22 repeats in white men. At the start of this work, a negative linear …
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Effects of sex, free testosterone, and androgen receptor cag repeat number on spatial cognition and virtual navigation performance
… of sex, testosterone, and androgen receptor CAG repeat number on spatial performance and experience in a group of healthy young men and women. The hypothesis that men would outperform women on measures of spatial skills was largely supported, with some caveats. Predictions that testosterone …
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Charakterisierung der Helicobacter pylori-assoziierten Magenadenokarzinogenese am Tiermodell des Mongolischen Gerbils: Rolle der cag-Pathogenitätsinsel bei der Induktion präkanzeröser Prozesse.
… H. pylori-Stämme (Typ I) das Effektorprotein CagA in die Wirtszelle zu translozieren, wird vermutlich eine Signaltransduktionskaskade gestartet, die auf die Physiologie und Architektur der Magenmukosa direkt regulatorisch wirkt. Ein Ziel dieser Arbeit war es, den Regulationsmechanismus der H. …
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Genetic, environmental and life-style effects on androgen receptor function
… (AR). The AR gene contains a polymorphic CAG repeat, encoding a stretch of glutamines, affecting the transcriptional activity of the AR. Prostate specific antigen (PSA) is a downstream target and is commonly used in the screening of prostate cancer. The relationship between CAG number and …
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Associations Between Testosterone, Androgen Receptor Polymorphism, And Mood
… in the androgen receptor (polyglutamine [CAG] repeat length) may be important for this relationship. However, the relationship between testosterone, androgen receptor CAG repeat length, and depressive affect remains inconclusive. The current thesis examined the association between …
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Detailed investigation of the unstable (CAG) repeat and the immediate surrounding region of the IT15 gene in some South African families with Huntington disease
The primary aim of this study was to investigate the origins of the HD mutation in South Africa (SA) by constructing a single nucleotide polymorphism (SNP) haplotype around the IT15 gene and to determine how many haplotypes there are in SA. Haplotypes were created by genotyping 6 SNPs in a total of …
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The impact of silver nanoparticles on plant physiology
… the impact of capped silver nanoparticles (cAg NPs) on terrestrial (Arabidopsis thaliana and Vicia faba) and aquatic (Lemna minor) plants was investigated. In addition, due to the important role of bacteria in plant survival and growth, this study also assessed the effect of cAg NPs on …
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Die Genotypen-Vielfalt in intergenischen Regionen des Bakteriums Helicobacter pylori : Aufbau von PCR-Assays zur Analyse der vacA-Promotor-Region und der Insertionsstelle der cag-Pathogenitätsinsel
… und an der Insertionsstelle der cag-Pathogenitätsinsel untersucht. Unsere Ergebnisse zeigen, daß genetische Variabilität auch in nicht-kodierenden DNA-Regionen des H.pylori-Genoms zu finden ist und daß die hier entwickelten PCR-Assays gut geeignet sind, andere etablierte Verfahren …
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Molecular investigation of the trinucleotide repeats within the Huntington disease gene in Southern Africa
… and entails the expansion of an unstable repeat (CAG)n within exon 1 of the, HD gene (IT-15). A polymorphic (CCG)n repeat has been identified immediately 3' to the unstable disease-causing (CAG)n repeat, which is in linkage disequilibrium on HD chromosomes. This study was undertaken to investigate …
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Superhydrophobic metrology and applications
… standard method, contact angle goniometer (CAG), is compared to two force-based measurement techniques: oscillating droplet tribometer (ODT) and micropipette force sensor (MFS). In addition, the properties of superhydrophobic surfaces are explored for lubrication. Publication I compares the …
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Using Chemically Modified Oligonucleotides to Modulate Gene Expression, Treat Genetic Diseases, and Probe Novel Mechanisms of RNA Interference
… is Huntington's disease (HD), which is caused by CAG trinucleotide expansion in the gene HUNTINGTIN (HTT) and production of toxic glutamine-expanded protein. Targeting HTT with siRNAs could be a powerful approach, but allele-selectivity is a major challenge: nearly all HD patients are heterozygous …
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Adeno-Associated Mediated Transduction of Sensory Epithelia Within the Guinea Pig Cochlea
… in mouse cochlear explants. Furthermore, the CAG promoter (also called CMV-beta-actin promoter) was shown to drive gene expression specifically in hair cells while the glial fibrillary acidic protein (GFAP) promoter drove expression in the non-sensory support cells. This in vivo study was …
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Adeno-Associated Mediated Transduction of Sensory Epithelia Within the Guinea Pig Cochlea
… in mouse cochlear explants. Furthermore, the CAG promoter (also called CMV-beta-actin promoter) was shown to drive gene expression specifically in hair cells while the glial fibrillary acidic protein (GFAP) promoter drove expression in the non-sensory support cells. This in vivo study was …
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A genetic screen to identify novel Helicobacter pylori virulence factors using Saccharomyces cerevisiae as a model eukaryotic cell
… 40-kb cytotoxin-associated pathogenicity island (cag PAl) that encodes and secretes the CagA protein into host epithelial cells via a type IV secretion system. To date, CagA is the only identified effector protein of the cag PAI. The goal of this study was to identify novel H pylori virulence …
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Jacking Loads and Ground Deformations Associated With Microtunneling
Fr=Cag' dptanCfFAcL Adjustments are appropriate for effects of delays, steering corrections, dewatering, etc.
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Die Rolle von Varianten des Kalzium-aktivierten Kaliumkanals KCNN3 bei sporadischer Migräne mit und ohne Aura
… Arbeit untersucht, inwiefern ein hochpolymorpher CAG-repeat-tragender Abschnitt des KCNN3-Gens zur Entstehung von sporadischer Migräne mit bzw. ohne Aura beiträgt. Der methodische Teil dieser Arbeit beinhaltete die Etablierung neuer Methoden zum Nachweis von triplet-repeat-Längenpolymorphismen. …
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Aplicação de diferentes processos físicos no creme de leite de cabra: efeito na estrutura e na lipólise convencional ou assistida por ultrassom
… a hidrólise, a concentração de ácidos graxos (CAG) foi determinada e os dados foram modelados para obter a taxa de hidrólise e a CAG final. Os pré-tratamentos promoveram aumento na taxa de hidrólise (até 3,9 vezes - efeito maior em baixas temperaturas) e na CAG final (aumento de até 9,4 vezes), …
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DNA Damage Response in Huntington’s Disease and Naked Mole Rat Brain Ageing
… in HD and identified potential modifiers of CAG expansion such as MBD4, PMS2, and RNASEH2A. Several hits from this arrayed CRISPR screen for modifiers of CAG repeat expansion converged on the regulation of R-loops, suggesting that these DNA-RNA hybrid structures may contribute to CAG repeat …
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