Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"CAFs"”.
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Fibroblast Heterogeneity In Pancreatic Cancer Immunity
… in wound healing, cancer associated fibroblasts (CAFs) are incredibly heterogeneous, leading to contradictions as to the roles CAFs play in the tumor microenvironment (TME). CAFs were thought to be a barrier to treatment of pancreatic ductal adenocarcinoma (PDAC). However, general stromal …
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Estudio de la influencia de los fibroblastos del estroma tumoral en el comportamiento de los carcinomas mamarios
Los fibroblastos asociados a tumor (CAFs) son el tipo celular más abundante en el estroma de los carcinomas mamarios y tienen acciones enfocadas a la promoción tumoral, incluyendo el reclutamiento de células inflamatorias. En un estudio previo, nuestro grupo observó que el 32% de los carcinomas de …
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Efeitos metabólicos da ingestão de farinha integral de soja do cultivar UFVTN 105AP em ratos alimentados com dieta equilibrada e obesogênica
… dieta de cafeteria com farinha integral de soja (CAFS). Foram avaliados o ganho de peso dos animais e o consumo alimentar; a concentração sérica de triglicerídeos, colesterol total, HDL-c, hemoglobina glicada, aspartato (AST) e alanina (ALT) aminotransferase; a concentração de TBARS no soro, …
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Functional Heterogeneity and Metabolic Adaptation of Fibroblasts In Cancer
… microenvironment, cancer-associated fibroblasts (CAFs) are a key component in the regulation of tumor development and progression, but their exact functions in tumorigenesis remain poorly understood. This is partly due to the considerable heterogeneity amongst these cells, which confounds the …
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Dissecting the interplay between cytotoxic T lymphocytes and the pancreatic cancer stroma
… predominantly by cancer-associated fibroblasts (CAFs), which restrict T cell access and undermine immunotherapeutic efficacy. To better understand how this stromal architecture shapes CTL behaviour, we developed an in vitro organotypic co-culture model that mimics key features of the PDAC tumour …
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Determining stromal evolution in response to immune checkpoint inhibition
… focusing on cancer-associated fibroblasts (CAFs). CAFs are an abundant and heterogeneous component of the TME, supporting tumourigenesis by secreting growth factors, cytokines, chemokines, extracellular matrix (ECM) and remodelling the physical environment. Indeed, these disparate functions …
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Defining the pro-tumour impact of the evolving stromal microenvironment
… In particular, cancer associated fibroblasts (CAFs) represent a diverse population of cells, which cannot be identified by one universal marker. CAFs promote tumour growth and dissemination by secreting growth factors, stimulating angiogenesis, aiding the development of tumour-promoting …
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Single cell and spatial analysis characterize metabolic DPEP1+ fibroblasts in PDAC
… the TME content of human PDAC. We characterized CAFs metabotypes and a novel CAF population expressing DPEP1, COMP, CST1, which involved in glutathione metabolism, termed "gluCAFs” and was associated with poor clinical outcomes and advanced PDAC stages. We also validate the existence of …
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Papel de los fibroblastos peritumorales en la progresión del cáncer de colon humano: desarrollo de un modelo animal
… atención en los fibroblastos peritumorales (CAFs), y el ColXIα1, que es un marcador específico de estas células. El objetivo de esta tesis es analizar la influencia de los CAFs en el cáncer de colon y el desarrollo de un modelo de xenotrasplante de cáncer de colon humano en ratones …
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Tumour infiltrating T cells in non-small cell lung cancer and their interactions with cancer-associated fibroblasts
… approaches. Cancer associated fibroblasts (CAFs) are the most abundant stromal cells of the tumour microenvironment (TME) and dampen the cytotoxic T cell (CTL) response in other solid tumours. Recently, CD39 has emerged as a marker to identify tumour relevant T cells and CD39 expression on …
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Tumor-Cell Derived Inhibin, Beta A Is Essential For Adrenergic Effects On Fibroblast Activation
… cells such as cancer-associated fibroblasts (CAFs) within the tumor microenvironment is limited. We hypothesize that adrenergic signaling and norepinephrine can accelerate the induction of CAF-phenotype to promote inflammation and metastasis.</p> <p><strong>Methods:</strong> Ingenuity Pathway …
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Unravelling the epigenetic landscape of pancreatic cancer: The role of cancer-associated fibroblasts in transcription factor regulation
… composed of cancer-associated fibroblasts (CAFs). Distinct populations of CAFs, including inflammatory CAFs (iCAFs) and myofibroblastic CAFs (myCAFs), have been identified and implicated in PDAC progression. However, the mechanisms that govern their crosstalk with the cancer cells are poorly …
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The chemokine CCL2/CCR2 signaling mediates cancer associated fibroblasts-cancer cells interaction and promotes basal-like breast cancer progression
… progression. Cancer associated fibroblasts (CAFs) are the most abundant stromal cells in breast cancer, but their function in cancer progression has not been fully understood. We previously identified that the chemokine CCL2 was highly expressed in breast cancer associated fibroblasts. CCL2 …
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Teaching and Learning in sustainable agriculture curricula: A case study of faculty work as learning at a land grant university
… in the Civic Agriculture and Food Sytems (CAFS) minor comprising core areas of experiential learning, interdisciplinary teaching and learning, and community engagement. This triad approach to teaching and learning brings together a framework for understanding faculty work as a social …
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The Role of The Hypoxia-Inducible Factor 2 In Pancreatic Cancer: Mechanisms of Tumor Immunosuppression and Intestinal Radioprotection
… actin+ (αSMA+) cancer-associated fibroblasts (CAFs) are the most abundant stromal component, as well as mediators of stromal deposition. The hypoxia-inducible factors (HIF1 and HIF2) coordinate responses to hypoxia, yet, despite their known association to poor patient outcomes, their functions …
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The role of the tumour microenvironment components in cancer cell behaviour and drug response
… sources of cancer-associated fibroblasts (CAFs) in solid tumours. The expression of CAFs markers, α-SMA and vimentin, increased significantly in MSCs co-cultured with oesophageal and breast cancer cells indicating conversion of MSCs into cell-like CAFs. WHCO1 (oesophageal) and MDA MB 231 …
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Surface chemistry design and characterization of anion exchange and activated carbon fibers for critical contaminants removal
… (PVA) based Chemically Activated Carbon Fibers (CAFs) with optimized activation temperatures, Kynol based Activated Carbon Fibers (ACFs) and Phenolic based (CAFs) with post-treatment by nitric acid. NH3 adsorption performance was measured in flowthrough configuration at both 0% and 50% relative …
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The Role and Mechanism of The Homeobox Gene Hoxa9 In The Growth of Epithelial Ovarian Cancer
… abundance of cancer-associated fibroblasts (CAFs) in mouse xenograft models of EOCs and with a CAF-like gene signature in human tumors. However, HOXA9 did not induce CAF-like features in EOC cells. Expression of HOXA9 in EOC cells induced normal adipose and bone marrow-derived mesenchymal …
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Creación de un centro de acondicionamiento y preparación física en la ciudad de Popayán con la implementación de marketing en salud.
… frente a su competencia (Gimnasios y CAFs de la ciudad de Popayán) mediante un estudio minucioso y análisis estratégico de las condiciones actuales del mercado. En la construcción del plan estratégico se tiene como aliado al marketing en salud, como medio persuasivo para generar …
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