Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"CADHERIN, MECHANOTRANSDUCTION"”.
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E-cadherin mechanotransduction beyond cell-cell junctions
Cadherins and integrin receptors form crucial extracellular adhesive connections with, respectively, adjacent cells and the extracellular matrix, and transduce mechanical signals across cell membranes. The role of adhesive complexes in diseases, cardiomyopathies, atherosclerosis, cancer, stem cell …
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VE-cadherin mechanotransduction signaling and its regulation by extracellular matrix
… and serious pathological consequences. VE-cadherin—the primary adhesion molecule at cell-cell junctions in vascular endothelial cells—governs the barrier integrity of the vascular endothelium. Previous studies showed that increased tension on VE-cadherin triggers a mechanotransduction …
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Epidermal growth factor receptor is an essential component in E-cadherin force-transduction complexes
… on the structural functional analysis of E-cadherin and EGFR interaction and their role in mediating E-cadherin mechanotransduction. E-cadherin serves as molecular Velcro in epithelial cells to maintain epithelial homeostasis. Despite passively bearing mechanical stress at cell-cell …
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Mechanical regulation of cell-cell junctions
Cadherins are cell-cell adhesion proteins that mediate cell recognition, segregation, and signaling in many tissues. Recent findings demonstrated that type I classical cadherin complexes are mechanosensitive. Mechanical forces in the tissue environment play a profound role in the growth, …
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Mechanotransduction at cell-cell contacts
… it was debated as to whether the differences in cadherin- dependent cell-cell adhesion energies could solely predict cell sorting. Although adhesion energies do influence cell sorting in vitro, recent studies suggested that that differences in cell adhesion, determined mainly by cadherin binding …
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Cadherin specificity in adhesion and mechanotransduction
Cadherins mediate Ca2+ dependent cell-cell junction in all animal tissues. Tight regulation of cadherin adhesion plays critical roles in diverse biological processes. Differential binding between cadherin subtypes is widely believed to mediate cell sorting during embryogenesis. However, a …