Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"CA3-CA1"”.
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BDNF-TrkB Signaling in Efficacy of CA3-CA1 Synapses and Ketamine-Mediated Antidepressant Effects
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Knockout of the glutamate transporter GLT-1 specifically from neurons drastically alters transcriptome profiles in CA3, CA1, and Striatum
… with excitatory terminals, particularly in CA3 pyramidal neuron axon terminals within CA3 and CA1 as well as in cortical layer V pyramidal neuron axon terminals within striatum. The specific functions of GLT-1 in axon terminals in regulating glutamate homeostasis and synaptic transmission …
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CaMKII at a central synapse : α-calcium/calmodium protien kinase II and synaptic plasticity at CA3 Schaffer collateral -- CA1 synapses in the mammalian hippocampus
… (LTP) of synaptic transmission at the CA3-CA1 hippocampal synapse is a model synaptic plasticity mechanism that may underlie hippocampal dependent learning and memory. Inhibition of post-synaptic calcium/calmodulin protein kinase II (CaMKII) has been shown to block LTP, and a global …
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Functional Characterization of Hippocampal Synapses in a Mouse Mutant of the Dystrobrevin Binding Protein 1 (DTNBP 1) Gene
… excitatory basal synaptic transmission at the CA3-CA1 connection of juvenile mice, which has not been reported in the literature. To understand this novel phenomenon in better detail, a series of experiments was performed in hippocampal slices and cultures to functionally dissect the specific …
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Molecular Mechanisms of Presynaptic Plasticity and Function in the Mammalian Brain
… paired-pulse ratios (PPRs). At the hippocampal CA3-CA1 synapse previous pharmacological studies suggested that PKC mediates PTP. A genetic approach helped to show that calcium dependent PKCs do not seem to be required for CA3-CA1 PTP. Pharmacologically inhibiting protein kinase A as well as …
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Antioxidants in Normal and Epileptic Brain: Effect on Synaptic Plasticity, Neural Network Physiology, and Memory
… high-frequency oscillations; SPW-HFOs), at the CA3-CA1 synapse, were examined using an extracellular multi-electrode array in in vitro mouse hippocampal slices. It was determined that under physiological conditions AA participates in the refinement of signal processing and memory formation …
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Developmental plasticity of the glutamate synapse: Roles of low frequency stimulation, hebbian induction and the NMDA receptor
… LTP and LTD, using the neonatal rat hippocampal CA3-CA1 synapse as a model synapse. This thesis shows that very low frequency induced depression is related to NMDA receptor dependent LTD. While elicited even during NMDA receptor blockade, this plasticity is facilitated and stabilized by NMDA …
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Low-Frequency-Induced Synaptic Potentiation: a Paradigm Shift in the Field of Memory-Related Plasticity Mechanisms?
… stimulation (1 Hz) of the medial septum (MS) and CA3 hippocampal (H) commissural fibres results in a long-lasting potentiation of field excitatory postsynaptic potentials (fEPSPs) in CA1 of urethane-anesthetised rats (MS-H-LTP). MS-H LTP is long lasting (>5 h), requires a specific inter-stimulus …
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Cell-type specific CB1 receptor modulation of hippocampal synaptic plasticity and memory
… control long-term potentiation (LTP) of CA3-CA1 synaptic transmission and long-term recognition memory. By allowing physiological availability of D-serine at NMDA receptors via gliotransmission, astrocytes are important elements controlling glia-neuron interactions that underlie synaptic …
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Identification and Characterization of Novel Mechanisms of Functional and Structural Synapse Remodeling: Focus on Vav Guanine Nucleotide Exchange Factors and MEF2 Transcription Factors
… rapid BDNF-induced dendritic spine growth and CA3-CA1 LTP. Furthermore, Vav2/3-deficient mice have impaired contextual fear conditioning, as well as reduced anxiety. Together, findings support a role for Vav-dependent F-actin dynamics in BDNF-stimulated dendritic spine head enlargement and LTP, …
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Ruolo del recettore CB1 cellulare e sub-cellulare in cellule D1-positive dell'Ippocampo nei Processi della Memoria
… in vivo long-term potentiation (LTP) in the CA3-CA1 pathway as the main cellular mechanisms for memory impairment in D1-CB1- KO. Thus, we provided functional evidence for the involvement of a small subclass of type-1 cannabinoid receptor (CB1)-expressing hippocampal interneurons in the …
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Using Multimodal MRI Techniques to Understand the Role of Hippocampus in Schizophrenia
… lower the LTP threshold in its target region CA3, thus generates increased associative function in CA3, resulting in memories with psychotic content. The loss of mnemonic functions in dentate gyrus could decrease its pattern separation function. Multimodal MRI techniques including proton …