Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 90 for “"CA3"”.
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BDNF-TrkB Signaling in Efficacy of CA3-CA1 Synapses and Ketamine-Mediated Antidepressant Effects
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Knockout of the glutamate transporter GLT-1 specifically from neurons drastically alters transcriptome profiles in CA3, CA1, and Striatum
… with excitatory terminals, particularly in CA3 pyramidal neuron axon terminals within CA3 and CA1 as well as in cortical layer V pyramidal neuron axon terminals within striatum. The specific functions of GLT-1 in axon terminals in regulating glutamate homeostasis and synaptic transmission …
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CaMKII at a central synapse : α-calcium/calmodium protien kinase II and synaptic plasticity at CA3 Schaffer collateral -- CA1 synapses in the mammalian hippocampus
… (LTP) of synaptic transmission at the CA3-CA1 hippocampal synapse is a model synaptic plasticity mechanism that may underlie hippocampal dependent learning and memory. Inhibition of post-synaptic calcium/calmodulin protein kinase II (CaMKII) has been shown to block LTP, and a global …
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Influence of perforant path synaptic excitation on the initiation of hippocampal sharp-wave ripple activity in vitro
Sharp-wave ripples (SWR) generated in the CA3 subregion of the hippocampus (HC) during rest and sleep appear to coordinate memory consolidation to the neocortex (NC) by (1) reactivating small subsets of neurons (i.e. cell-assemblies) that encode recent waking experience and (2) propagating this …
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Electrophysiological characterization of a mouse deficient for oligophrenin1: a mouse model of X-linked mental retardation
… Investigation of the synaptic properties of CA3 pyramidal neurons using the patch-clamp technique has been undertaken. I have shown reduced inputs of excitatory and inhibitory neurotransmission to CA3 pyramidal neurons accompanied with reduced frequency dependent facilitation of the …
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From space to episodes : modeling memory formation in the hippocampal-neocortical system
… is based on an attractor network model of area CA3 in which recurrent interactions create place cell representations from location- and direction-specific activity in the entorhinal cortex, all under neuromodulatory influence. In unfamiliar environments, mossy fiber inputs impose activity …
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Tracking The Flow of Information Through The Hippocampal Formation In The Rat
… pattern completion, hypothesized to occur in the CA3 region, refers to the ability to reproduce a previously stored output pattern from a partial or degraded input pattern. Prior to addressing the functional role of the DG and CA3 subfields, the spatial firing properties of neurons in the dentate …
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Ribonomic Control During Global Brain Ischemia And Reperfusion
… of ELAV protein family member detected in CA1/CA3 in Hu protein immunoprecipitation and polysomes was HuB (Rel-N1). HuB is present in control CA3, 8 hr reperfused CA3, and 8 hr reperfused CA1, but absent from control CA1. AUF-1, hnRNP K, hnRNP M were also absent from control CA1 following Hu …
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Glutamate Dysregulation in a TauP301L Mouse Model of Alzheimer's Disease
… network hyperexcitability, particularly in the CA3 region of the hippocampus, in the years preceding AD diagnosis, suggesting that aberrant network activity might contribute to the pathogenesis of AD. Recently, the microtubule-binding protein tau has been implicated in this hyperexcitability. …
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Molecular mechanisms of memory formation : using activity regulated genes to identify active neural circuits
… is selectively induced in a sparse population of CA3 following contextual fear conditioning. Global knockout or selective deletion of Npas4 in CA3 both resulted in impaired contextual memory, and restoration of Npas4 in CA3 was sufficient to reverse the deficit in global knockout mice. Taking …
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Investigation of RNA-Binding Protein Expression Changes in the Hippocampus Following Doxorubicin and Cyclophosphamide Treatment
… reduced GFAP-positive area in cornu ammonis 3 (CA3) (24%, pB=0.026) and dentate gyrus (DG) (19%, pB=0.027) regions, and elevated cellular senescence marker p19Arf specifically in DG (69%, pB=0.033) and CA3 (27%, pB=0.024). The inverse relationship between hnRNPA1 reduction and p19Arf elevation …
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Investigation Of Posttranscriptional Regulation After Global Brain Ischemia And Reperfusion Injury
… neurons from hippocampal subregions CA1 and CA3. </p> <p>We found that mRNA granules can be prevented in reperfused neurons by locking mRNA onto polysomes with cycloheximide. In uninjured neurons, mRNA granules can be induced with puromycin, which promotes early translation termination and …
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Physiological mechanisms of hippocampal memory processing : experiments and applied adaptive filtering
… within and between hippocampal subregions (CA1, CA3, and dentate gyrus) that mediate these memory processing functions are not completely understood. We investigate by recording in the hippocampal subregions as rats execute an augmented linear track task. From these recordings, we construct …
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Using Multimodal MRI Techniques to Understand the Role of Hippocampus in Schizophrenia
… lower the LTP threshold in its target region CA3, thus generates increased associative function in CA3, resulting in memories with psychotic content. The loss of mnemonic functions in dentate gyrus could decrease its pattern separation function. Multimodal MRI techniques including proton …
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Serotonin Modulates the Maturation of the Medial Prefrontal Cortex and Hippocampus: Relevance to the Etiology of Emotional and Cognitive Behaviors
… but increased branching in the cornu ammonis 3 (CA3) sub-field. PN-FLX treatment also reduced total synapse number and synaptic density of CA3 neurons. In order to probe the functional consequences of these morphological changes, we investigated spatial learning in the Morris water maze and …
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Effects of Regional Deletion of Rab3A-interacting Molecule and PTEN on Brain Function
… RIM1 from the hippocampal dentate gyrus and area CA3, while adeno-associated virus expressing PTEN-directed interference RNA was injected into the basolateral amygdala to knockdown PTEN in local pyramidal neurons. In the case of RIM1, I hypothesized that deletion of RIM1 from the dentate gyrus or …
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Hippocampal Subfield Transcriptome Analysis in Schizophrenia Psychosis
… memory, critically involving dentate gyrus (DG), CA3, and CA1 of the hippocampus. Therefore, this doctoral dissertation examines the transcriptome of all three subfields, DG, CA3, and CA1 in human postmortem tissue of controls and individuals diagnosed with schizophrenia, using RNA-seq to identify …
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Impact of Corticosterone and Zinc Deprivation on Memory and Hippocampal Functioning
… memory tasks. A decrease in the hippocampus area CA3 pyramidal cell layer width was observed in the animals treated with CC. Performance on the radial arm maze was significantly correlated with the width of the CA3 pyramidal cell layer. Performance on the water maze was significantly correlated …
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