Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"CA125"”.
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The Utility of CA125 for the Detection of Ovarian Cancer in Primary Care
… to improve these outcomes. Cancer antigen 125 (CA125) is recommended by the National Institute for Health and Care Excellence (NICE) as the first line test for ovarian cancer in symptomatic women presenting to primary care in England. However, the performance of CA125 in this setting is unknown. …
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Biomarkers of disease : concentrations in the serum of women during natural and stimulated ovarian cycles and during early pregnancy
… measured were prostate specific antigen (PSA), CA125, CA15‐3, CA72‐4, and pregnancy associated plasma protein‐a (PAPP‐A). The patterns of change during natural and stimulated ovarian cycles and early pregnancy were investigated to determine if these biomarkers could reflect normal events …
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The Use of Transvaginal Ultrasound and Biochemical Markers in the Diagnosis of Endometriosis.
… of tenderness mapping, symptomatology and serum CA125 measurement both on their own and in addition to ultrasound.<br/>The introduction to this thesis discusses: the pathogenesis and impact of<br/>endometriosis; the literature regarding the diagnostic tests available including MRI<br/>and …
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Diagnóstico de derrame pleural maligno mediante la concentración de homocisteína en líquido pleural
… (CEA), antígeno del cáncer (CA) 15.3, CA19.9 y CA125; y desarrollar un modelo probabilístico para diferenciar los DPMs de los benignos (DPBs) con la combinación de estos biomarcadores. Métodos: se estudiaron pacientes con derrame pleural. Los pacientes se clasificaron en dos grupos según la …
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Avaliação da pesquisa de autoanticorpos em células Hep-2 como biomarcador em neoplasias hepáticas, pancreáticas e biliares
… anticorpos com os marcadores tumorais CA19.9 e CA125. Os níveis desses marcadores estavam aumentados quando o FAN foi negativo. De acordo com nossos resultados, os autoanticorpos foram mais prevalentes no soro de pacientes com câncer, em relação ao grupo controle porém ainda se faz necessário …
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The development of a blood-based test of DNA methylation for the earlier detection of high-grade serous tubo-ovarian cancer
… Diagnostic accuracy was improved compared to CA125 in two markers. Statistically significant hypermethylation (p=0.009) was detected using MSRE qPCR in plasma cell free DNA (cfDNA) for one marker.Conclusions This study has provided a proof-of-principle for the identification of novel DNAme …
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Integrating High-throughput Technologies for the Identification and Validation of Novel Ovarian Cancer Biomarkers
… clinically-approved markers for ovarian cancer - CA125 and HE4 alone - perform poorly for the mucinous, endometrioid and clear cell subtypes and thus, diagnosis of these subtypes remains a significant challenge. To this end, an integrated approach to ovarian cancer biomarker discovery was …
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The role of Mullerian differentiation in epithelial ovarian carcinogenesis
… the differentiation markers keratin, E-cadherin, CA125 and OVGP1. Neither disruption of the growth pattern nor manipulations of the cadherin profile induced invasivenesss. Induction of invasiveness by SV40 early genes was associated with a loss in morphologic differentiation and of differentiation …
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The uPA receptor in ovarian cancer. Regulation by EGF and the estrogen responsive membrane receptor GPR30. Soluble uPAR in diagnosis and prognosis.
… the combination of suPAR(I-III + II-III) and CA125 gave better discrimination between benign and invasive tumors (AUC 0.94) than either marker alone. Moreover, a high preoperative level of uPAR(I) was an independent predictor of poor prognosis. Thus, suPAR forms can both serve as markers for …
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Targeting mdr1 and endocrine therapy-resistant cancers through estrogen receptor
… tumor burden and the circulating tumor antigen, CA125, to undetectable levels. Taken together, these studies demonstrate the importance of cross-talk between steroid hormone action and the anticipatory UPR pathway in the development of hormone-dependent cancer. We show that targeting anticipatory …
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Primary Fallopian tube carcinoma : occurrence, risk and prognostic factors
… Pretreatment serum concentrations of hCGβ, CA125 and TATI were evaluated as prognostic markers for PFTC. Elevated hCGβ values (above the 75th percentile, 3.5 pmol/L; OR 2.49, 95% CI 1.22 5.09), stage and histology were strong independent prognostic factors for PFTC. The effects of parity, …
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Immunocytochemical typing of primary tumors on fine needle aspiration cytologies of the liver and lymph nodes
… a marker panel consisting of CK5/6, CK7, CK20, CA125, TTF1, and Cdx2, BerEP4, LCA, TTF1, CD56, Chromogranin A and Synaptophysin were used when there was a cytological and/or clinical suspicion for a metastatic neuroendocrine carcinoma. 10 FNACs of lymph nodes were analysed for the …
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Proteomics characterization of HPV-independent Vulvar Cancer Tumour Progression and Metastasis by Mass Spectrometry
… yet. Tumour biomarkers, such as TP53 and CA125, do not have enough sensitivity and specificity in vulvar cancer detection. Therefore, new protein biomarker candidates are needed for current vulvar cancer diagnosis and prognosis. Mass spectrometry (MS) is a high-throughput protein analysis …