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Showing 1 to 20 of 98 for “"C8"”.
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Human Complement Protein C8: Crystal Structure and Analysis of Binding Interactions
Human C8 is part of the membrane attack complex (MAC) that assembles on bacterial cell membranes to form a lethal pore-like structure. The MAC is comprised of complement proteins C5b, C6, C7, C8 and C9. The 150-kDa C8 protein consists of three non-identical subunits (C8alpha, C8beta, C8gamma), …
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Metabolic flux analysis of Escherichia coli MG1655 under octanoic acid (C8) stress
… chain fatty acids (SCFAs) such as octanoic acid (C8)] are such chemical intermediates that can be produced by Escherichia coli engineered with thioesterases specific for short chain fatty acids. However, C8 is toxic to E. coli at concentration greater than 10 mM. To design a better host strain for …
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C8-Arylguanine Modified Hairpin Oligonucleotides: Synthesis, Conformational Analysis, and Tools for the Investigation of Z-DNA Formation
… our lab has demonstrated that the formation of C8-arylguanine DNA adducts, derived from arylhydrazines, shifts the B /Z DNA equilibrium toward the Z-DNA conformation in d(CG)5 sequences. However, our previous work examined the effect of two adducts in the duplex and it was unclear whether the …
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Aufklärung des Einflusses von C7 und C8 Aromaten auf die Partikelbildung im Abgas von Ottomotoren mit Direkteinspritzung sowie Entwicklung eines Screeningverfahrens zur Vorhersage der Partikelbildung
… particular, to identify the influence of C7 and C8 aromatics. The fuels are tested in stationary and dynamic tests on engine and chassis dynamometers. Particle number emissions are recorded using a condensation particle counter. In contrast to larger, more resonance-stabilized aromatics, toluene …
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Directed Palladium Catalyzed Acetoxylation of Indolines and Enantioselective Total Synthesis of (–)-Voacinol and (–)-Voacandimine C
… the synthesis of the corresponding hexacyclic C8-aminonitrile. Stereocontrolled methylenation of a C8-enamine derivative of deoxoapodine, accessed by ionization of the C8-aminonitrile, afforded a symmetrical dodecacyclic bis-aminonitrile. Final-stage biogenetically inspired controlled reductive …
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Studies on the synthesis of bisindole Aspidosperma alkaloids
… the synthesis of the corresponding hexacyclic C8-aminonitrile. Stereocontrolled methylenation of a C8-enamine derivative of deoxoapodine, accessed by ionization of the C8-aminonitrile, afforded a symmetrical dodecacyclic bisaminonitrile as a versatile precursor to these bisindole alkaloids. …
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DEVELOPMENT OF NOVEL COPOLYOXETANES: ANTIMICROBIAL AGENTS
… of alkyl chain length on MIC was found with C8-50 being the most effective antimicrobial. Kill kinetics for C8-50 (5× MIC, challenge: 108 cfu/ml) effected >99% kill in 1 hour for S. aureus (7 log reduction). C8-50 efficacy on biomass and cell viability of P. aeruginosa biofilms was …
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Development of imidazotetrazines for the treatment of glioblastoma & as synthetic precursors to diazo species
… provided access to several new classes of C8-substituted imidazotetrazines and an evaluation of their aqueous stabilities enabled the derivation of a predictive model for imidazotetrazine hydrolytic stability based on the Hammett constant of the C8 substituent. Promising compounds modified …
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Charge transport and spectroscopic analysis of high-mobility molecular semiconductors
… properties of the molecular semiconductor C8-DNTT-C8 using conducting atomic force microscopy (C-AFM). The chapter describes C-AFM measurements conducted on single crystal films of C8-DNTT-C8 characterized by a layered morphology and a 2D character. By studying local changes in electric …
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Elucidating mechanisms of toxicity and engineering Escherichia coli for tolerance of short chain fatty acids
… improve tolerance.</p> <p>Hexanoic, octanoic (C8), and decanoic acids are completely inhibitory to Escherichia coli MG1655 in minimal medium. This growth inhibition is pH-dependent and is accompanied by a significant change in the fluorescence polarization (fluidity) and integrity. This …
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Mechanistic Studies of the Structure-Photostability Relationship of Organic Conjugated Polymers
… y(2,5-dioctyl-1,4-phenylene-1,2-dicyanovinylene) (C8-diCN-PPV) and poly(2,5-bis(decyloxy)- 1,4-phenylene-1,2-dicyanovinylene) (RO-diCN-PPV). The second series included a wellknown polymer, poly(3-hexylthiophene) (P3HT), and a newly synthesized CP, Poly(3,5- …
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Hepatic acetogenesis and ketogenesis in neonatal swine
… change in plasma ($\beta$-OHB) relative to (C8:0) (regression slope) following a dose of C8:0. This slope was 1-2 orders of magnitude lower vs. that of mature pigs and newborn or mature rabbits. Minimal fatty acid carboxyl-carbon accumulated in ketone bodies after incubations of piglet liver …
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Improvement in Energy Conversion and Energy Storage Applications by Liquid Crystals and Carbon Nanoparticles
… cell technologies, a smectic liquid crystal C8-BTBT was selected in Chapter 3 due to its unique thermal dynamic and crystal properties. A range of ternary OSCs with and without C8-BTBT loading at gradient weight fractions were thermally treated and fabricated. In addition, the assessment of …
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Deuterium Tracer Study Of The Mechanism Of Iron Catalyzed Fischer-Tropsch Synthesis
… showed that the H/D ratios in alkanes from C8 to C19 were less than 1. It clearly indicates that there is deuterium enrichment during iron catalyzed FT reactions. Unlike Co catalyzed FTS, in which the H/D ratio decreased with increasing carbon numbers, the H/D ratio in iron catalyzed FTS …
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Synthesis, Structure, and Catalytic Activity of Bimetallic Rhodium Complexes in the Hydroformylation and Allylic Oxidation of Alkenes
… mixed ligand heteroleptic dirhodium complexes C8 – C11 of the type [Rh2(R-dpf)x(OAc)4-x] with x = 2 or 3 (where R = H, CH3 or F), respectively (Figure 1). The complexes were fully characterised using various spectroscopic and analytical techniques inclusive of the melting points, 1H NMR, 13C …
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Regulação da adipogênese e da secreção de quemerina por ácidos graxos de cadeia média e pelo ácido graxo eicosapentaenóico em células 3T3-L1
… objetivou avaliar o efeito do EPA e de AGCM (C8:0 e C12:0) sobre a adipogênese em células 3T3-L1. Além disso, avaliou-se o efeito desses ácidos graxos sobre a expressão de mRNA e secreção de quemerina, uma nova adipocina envolvida na adipogênese. Para isso, preadipócitos foram cultivados em …
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A general scaffold for the synthesis of cysiherbaine and its analogues
… for the easy variation of the important C8-amino C9-alcohol pharmacophore. The molecule 4 has a double bond between the C8 and C9 position as the key reactive functional group. The principal reactivity that will be used to synthesize derivatives of this molecule involves the double bond. …
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Investigating the chemistry of lipoyl synthase
… sulfur insertions into the unactivated C6 and C8 centres of a protein-bound octanoyl group. Using an in vitro assay which makes use of a small peptide mimic of the protein substrate, it has now been shown at which carbon centre sulfur insertion first occurs. LCMS analysis of reactions using …
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