Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"C5aR"”.
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THE ABSENCE OF C3AR AND C5AR SIGNAL TRANSDUCTION PROMOTES T REGULATORY CELL DIFFERENTIATION AND REGULATES IMMUNOLOGIC TOLERANCE
Here, we demonstrate that when C3aR and C5aR signals are not transduced into CD4+ T cells, PI-3K¿-AKT-mTOR signaling ceases, PKA activation increases, auto-inductive TGF-ß1 signaling initiates, and CD4+ T cells become Foxp3+ T regulatory cells (iTregs). Endogenous TGF-ß1 suppresses C3aR and C5aR …
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The Role of The C5A Receptor In Host Defense Against Listeria Monocytogenes
… the C5a receptor is essential for host defense. C5aR-/- mice have reduced survival and increased bacterial burden in the liver and spleen in comparison to WT mice. Surprisingly, C5aR-/- mice also have a dramatic reduction in splenocyte numbers resulting from elevated cell death as indicated by …
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Herstellung und Charakterisierung monoklonaler Antikörper gegen die Anaphylatoxin-Rezeptoren
… monoklonale Antikörper gegen den humanen C5aR und erstmals solche Reagenzien gegen den Maus-C3aR hergestellt werden. Mit Hilfe dieser neu generierten monoklonalen Antikörper sollte die Expression sowohl des C5a- als auch des C3a-Rezeptors im normalen und pathologisch veränderten …
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Ligand induzierte Phosphorylierung des Chemokin Rezeptors CCR5: strukturelle Analyse und Funktion
… auch Heterodimere mit dem C5a Rezeptor (C5aR) und zu einem geringeren Maße mit dem Angiotensin Rezeptor II Typ 1a (AT1aR). Durch Coexpression von CCR5 mit C5aR oder AT1aR konnte eine signifikante CCR5-Cointernalisierung nach heterologer C5a-Stimulation beobachtet werden, die bei …
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The role of complement FH and apoE interactions in the regulation of Aβ1-42 and C1q-mediated complement activation
… formation of C5a and activation of C5a receptor (C5aR) expressed on Human embryonic kidney (HEK) 293 cells. The presence of all apoE isoforms on Aβ1-42/C1q complexes led to reduced C5aR activation. Surprisingly, however, the reduction was the largest with apoE4, and the presence of C1q on Aβ1-42 …
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Staphylococcus aureus virulence factors dictate host signaling pathways and immune responses
… hypothesized that CHIPS inhibited C5a receptor (C5aR) signaling. Monocytes pretreated with CHIPS did not inhibit C5aR signaling. Nevertheless, signaling pathways can reduce PMN function in models such as glucocorticoid treatment. Immunosuppressive effects of glucocorticoids on PMN are restored …
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Cervical Remodeling/ripening At Term And Preterm Delivery: The Same Mechanism Initiated By Different Mediators And Different Effector Cells
… response to LPS or RU486, suggesting a role for C5aR in the cervical changes that precede PTD. In vitro studies show that macrophages release MMP-9 in response to C5a. Progesterone diminished the amount of C5aR on the macrophages surface, inhibited the release of MMP-9 and prevented PTD. In …
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The role of anaphylatoxins in asthma and airway remodelling
… with the G protein-coupled receptors, C3aR and C5aR respectively. Activation of the complement system has been implicated in the pathogenesis of many inflammatory diseases including asthma. Little is known, however, about the expression and location of complement components in asthmatic airways. …
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ROLE OF P50 NF-KB IN MACROPHAGE MIGRATION
… recruitment. In particular, a F4/80high-C5aR (CD88)high macrophage population was still recruited in response to C5a, in the air pouch of LPS-tolerant mice, supporting the functional activity of this pathway in in vivo tolerant conditions. Similarly, also tumor associated macrophages …