Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"C57BL/6J Mice"”.
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Behavioral Changes in Adult C57BL/6J Mice following Prenatal Exposure to Ethanol.
… represents a model for binge drinking, in which C57BL mouse embryos were exposed to alcohol during 2 separate critical periods of brain development, gestational day (GD) 7 or 8. As adults, the offspring were tested to determine if loco-motor activity and emotional reaction to a novel environment …
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Cannabinoid Modulation of Reinforcement Maintained by Stimulation of the Medial Forebrain Bundle in C57Bl/6J Mice
… SA-57 in ICSS of the medial forebrain bundle in C57BL/6 mice. Additionally, we assessed the psychomotor stimulant cocaine as a positive control to facilitate ICSS. These studies were complimented with spontaneous locomotor activity and food-maintained operant experiments to assess the sensitivity …
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The effects of a high fat diet on musculoskeletal health in aged male C57BL/6J mice
… on bone and muscle structure and function. Male C57BL/6J mice were randomized 1 of 2 diets: control (AGE, AIN93M, 10.3% kcal fat, 100 g/kg sucrose) or HFS (HFS-AGE, 45.3% kcal fat 200 g/kg sucrose) for 13 weeks starting at 20 weeks of age to represent middle age. Trabecular bone structure and …
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Neuroanatomical Maps and Taste Reactivity to Sweet, Umami, and Bitter Taste in the PBN of C57BL/6J Mice
… measure the ability of rodents (including inbred mice) to discriminate between the different taste qualities. Taste reactivity and two-bottle preference are behavioral tests that are utilized to investigate different aspects of taste. These tests involve either voluntary or forced consumption of …
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A COMPARISION OF DELTA-9-TETRAHYDROCANNABINOL DEPENDENCE IN C57Bl/6j MICE AND FATTY ACID AMIDE HYDROLASE KNOCK OUT MICE
… elevating endogenous anandamide levels using mice lacking fatty acid amide hydrolase (FAAH), the enzyme responsible for anandamide metabolism, would ameliorate THC dependence. Mice were treated subchronically with a low or high THC dosing regimen and challenged with the CB1 receptor …
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The effect of voluntary binge caffeine and ethanol coexposure on neurobehavioral sensitivity to cocaine in male C57BL/6J mice
… binge caffeine and alcohol co-consumption. Male C57BL/6J mice underwent 14 days of daily, 2hr limited access to water, alcohol, caffeine, or combined caffeine and alcohol. Water was freely available after these sessions. In Experiment 1, mice underwent an 11-day locomotor sensitization protocol …
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The effect of voluntary binge caffeine and ethanol co-exposure on neurobehavioral sensitivity to cocaine in male C57BL/6J mice
… binge caffeine and alcohol co-consumption. Male C57BL/6J mice underwent 14 days of daily, 2hr limited access to water, alcohol, caffeine, or combined caffeine and alcohol. Water was freely available after these sessions. In Experiment 1, mice underwent an 11-day locomotor sensitization protocol …
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MUSCARINIC ACETYLCHOLINE M2 RECEPTORS INCREASE IN CHOLINERGIC INTERNEURONS OF THE NUCLEUS ACCUMBENS FOLLOWING BINGE ALCOHOL DRINKING IN C57BL/6J MICE
… accumbens following binge alcohol drinking in C57BL/6J mice. Binge alcohol drinking, however, had no significant effect on the volume of the nucleus accumbens or the volume of accumbal cholinergic interneurons. These findings may provide the groundwork for future studies that may aim to develop …
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Protective effect of TM-25659, known as TAZ activator, on high-fat diet-induced insulin resistance in C57BL/6J mice
… restored the insulin signaling pathways in DIO mice skeletal muscle 33 F. TM-25659 lowered the muscle pro-inflammatory cytokine levels in DIO mice 35 G. TM-25659 regulates expression of both FGF21 mRNA and protein in DIO mice skeletal muscles 37 Ⅳ. DISCUSSION 38 Ⅴ. CONCLUSION 42 PART 2. …
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Effect of GABRA2 expression in the central nucleus of the amygdala on anxiety and alcohol's anxiolytic capacity in C57BL/6J mice
… behavior and alcohol’s anxiolytic effects in mice. C57BL/6J (B6) mice underwent surgery for bilateral infusion of GFP-tagged lentivirus targeting Gabra2 or a scramble control lentivirus into the CeA. Following 12-13 days of recovery, mice were assessed for anxiety-like behavior in the elevated …
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Investigating the role of extrasynaptic GABAA receptors located in the infralimbic cortex in the binge-like alcohol intake of male C57BL/6J mice
… (ILC) in the binge-like alcohol intake of male C57BL/6J (B6) mice. The ILC is of interest due to its demonstrated involvement in stress reactivity and alcohol exposure has been shown to interfere with extinction learning; impairments of which may be related to inflexible behavior (i.e. …
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Effect of Delta-Tocotrienol and Grape Seed Polyphenol on Lipid Profile in C57BL/6J Mice with a Western-Like Diet-Included Non-Alcoholic Steatohepatitis
… and combined: GSP - 2%; d-T3 - 0.05%) in C57BL/6J mice fed a high calorie high fat diet for 20 weeks. Hepatic cholesterol, triglycerides, and vitamin E; serum cholesterol, triglycerides, vitamin E, and free fatty acids were assayed. Hepatic total cholesterol was lowest in GSP diet and …
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Array-based genomic diversity measures portray Mus musculus phylogenetic and genealogical relationships, and detect genetic variation among C57Bl/6J mice and between tissues of the same mouse
… measured between distantly and closely related mice correlates with known phylogeny and genealogy. Variation detected between C57BL/6J mice is consistent with previous reports of variants within this strain. Putative genetic variation detected between and within tissues indicates somatic …
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Neonatal Maternal Separation and Alcohol Abuse in C57BL/6J mice: A Study of the Functional Alterations of GABAergic and GLUergic Systems and the Possible Protective Role of Esterogen
… separation (RMS) on alcohol abuse in adult C57BL/6J mice and potential functional alterations of GABAergic and GLUergic systems in different brain areas. Male animals subjected to RMS consumed significantly higher amount of ethanol when compared to control counterparts. In addition, RMS is …
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Increased Severity of Murine Infection with Toxioplasma Gondii Following Vitaman E and Selenium Supplementatoin
… selenium would provide a beneficial effect in mice chronically infected with Toxoplasma gondii. In the first phase of the study, 35 female Swiss Webster mice were infected with oocysts of the Me49 strain of Toxoplasma gondii while receiving diets supplemented with vitamin E alone or in …
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A Single Alcohol Pre-exposure Alters Dorsolateral Striatal AMPA Receptor Dependent Binge and Compulsive-like Drinking
… quinine adulterated alcohol (QuA) drinking in C57BL/6J male and female mice, assess associated AMPA receptor protein expression in the dorsal striatum, and to antagonize DLS AMPA receptors during compulsive-like QuA drinking using a model of binge-like alcohol drinking, Drinking-in-the-Dark …
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Effects of physical exercise and exercise-induced adult hippocampal neurogenesis on conditioned place preference for cocaine in mice
… (CPP) for cocaine from exercise in male C57BL/6J mice. Since the conditioned place preference paradigm represents the major behavioral assay I employ in the proposed experiments, Chapter 1 presents a review of the relevant conditioned place preference literature. Chapter 2 examines the …
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H5N1 Influenza Virus Induces a Parkinsonian Pathology
… (CNS) to higher levels of the neuroaxis, using C57BL/6J mice that are infected by the A/VN/1203/04 H5N1 virus (without adaptation). In regions infected by H5N1 virus, we observe activation of microglia and alpha-synuclein phosphorylation and aggregation that persists long after resolution of the …
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Acute Sleep Fragmentation Induces Tissue-Specific Changes in Cytokine Gene Expression and Increases Serum Corticosterone Concentration
… prefrontal cortex, and hippocampus) in mice exposed to various intervals of sleep fragmentation. Serum corticosterone concentration was also assessed. Sleep was disrupted in male C57BL/6J mice using an automated sleep fragmentation chamber (Lafayette Industries), which involved movement …
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