Global ETD Search
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Showing 1 to 20 of 153 for “"C57BL/6J"”.
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Behavioral Changes in Adult C57BL/6J Mice following Prenatal Exposure to Ethanol.
… represents a model for binge drinking, in which C57BL mouse embryos were exposed to alcohol during 2 separate critical periods of brain development, gestational day (GD) 7 or 8. As adults, the offspring were tested to determine if loco-motor activity and emotional reaction to a novel environment …
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Cannabinoid Modulation of Reinforcement Maintained by Stimulation of the Medial Forebrain Bundle in C57Bl/6J Mice
… SA-57 in ICSS of the medial forebrain bundle in C57BL/6 mice. Additionally, we assessed the psychomotor stimulant cocaine as a positive control to facilitate ICSS. These studies were complimented with spontaneous locomotor activity and food-maintained operant experiments to assess the sensitivity …
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A Behavioral and Anatomical Analysis of Conditioned Taste Aversion in C57BL/6J and DBA/2J Mice
… strains of mice, specifically the common strains C57BL/6J (B6) and DBA/2J (D2), allows for the investigation of phenotypic variation and specific genes underlying the various components of CTA. B6 and D2 mice have previously been characterized in terms of various ingestive behaviors, making these …
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The effects of a high fat diet on musculoskeletal health in aged male C57BL/6J mice
… on bone and muscle structure and function. Male C57BL/6J mice were randomized 1 of 2 diets: control (AGE, AIN93M, 10.3% kcal fat, 100 g/kg sucrose) or HFS (HFS-AGE, 45.3% kcal fat 200 g/kg sucrose) for 13 weeks starting at 20 weeks of age to represent middle age. Trabecular bone structure and …
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Neuroanatomical Maps and Taste Reactivity to Sweet, Umami, and Bitter Taste in the PBN of C57BL/6J Mice
… similarity between sweet and umami compounds in C57BL/6J (B6) mice; stimuli of both taste qualities would produce similar levels of preference, consumption, and levels of taste reactivity behaviors. Secondly, I hypothesized that taste stimulation with either sweet (sucrose) or umami …
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A COMPARISION OF DELTA-9-TETRAHYDROCANNABINOL DEPENDENCE IN C57Bl/6j MICE AND FATTY ACID AMIDE HYDROLASE KNOCK OUT MICE
The idea that humans and laboratory animals can become physically dependent on marijuana or its primary psychoactive constituent, delta-9-tetrahydrocannabinol (THC), is gaining acceptance. However, there are no currently approved pharmacotherapies to treat cannabinoid withdrawal. The objective of …
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The effect of voluntary binge caffeine and ethanol coexposure on neurobehavioral sensitivity to cocaine in male C57BL/6J mice
… binge caffeine and alcohol co-consumption. Male C57BL/6J mice underwent 14 days of daily, 2hr limited access to water, alcohol, caffeine, or combined caffeine and alcohol. Water was freely available after these sessions. In Experiment 1, mice underwent an 11-day locomotor sensitization protocol …
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The effect of voluntary binge caffeine and ethanol co-exposure on neurobehavioral sensitivity to cocaine in male C57BL/6J mice
… binge caffeine and alcohol co-consumption. Male C57BL/6J mice underwent 14 days of daily, 2hr limited access to water, alcohol, caffeine, or combined caffeine and alcohol. Water was freely available after these sessions. In Experiment 1, mice underwent an 11-day locomotor sensitization protocol …
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MUSCARINIC ACETYLCHOLINE M2 RECEPTORS INCREASE IN CHOLINERGIC INTERNEURONS OF THE NUCLEUS ACCUMBENS FOLLOWING BINGE ALCOHOL DRINKING IN C57BL/6J MICE
… accumbens following binge alcohol drinking in C57BL/6J mice. Binge alcohol drinking, however, had no significant effect on the volume of the nucleus accumbens or the volume of accumbal cholinergic interneurons. These findings may provide the groundwork for future studies that may aim to develop …
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Protective effect of TM-25659, known as TAZ activator, on high-fat diet-induced insulin resistance in C57BL/6J mice
PART 1. TM-25659-induced activation of FGF21 level decreases insulin resistance and inflammation in skeletal muscle via GCN2 pathways 1 Ⅰ. INTRODUCTION 2 Ⅱ. MATERIALS AND METHODS 8 A. MATERIALS 9 B. METHODS 10 1. Preparation of PA 10 2. Cell culture 10 3. Immunoblot analysis 11 4. RNA isolation and …
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Effect of GABRA2 expression in the central nucleus of the amygdala on anxiety and alcohol's anxiolytic capacity in C57BL/6J mice
… and alcohol’s anxiolytic effects in mice. C57BL/6J (B6) mice underwent surgery for bilateral infusion of GFP-tagged lentivirus targeting Gabra2 or a scramble control lentivirus into the CeA. Following 12-13 days of recovery, mice were assessed for anxiety-like behavior in the elevated plus …
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Investigating the role of extrasynaptic GABAA receptors located in the infralimbic cortex in the binge-like alcohol intake of male C57BL/6J mice
… (ILC) in the binge-like alcohol intake of male C57BL/6J (B6) mice. The ILC is of interest due to its demonstrated involvement in stress reactivity and alcohol exposure has been shown to interfere with extinction learning; impairments of which may be related to inflexible behavior (i.e. …
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Effect of Delta-Tocotrienol and Grape Seed Polyphenol on Lipid Profile in C57BL/6J Mice with a Western-Like Diet-Included Non-Alcoholic Steatohepatitis
… and combined: GSP - 2%; d-T3 - 0.05%) in C57BL/6J mice fed a high calorie high fat diet for 20 weeks. Hepatic cholesterol, triglycerides, and vitamin E; serum cholesterol, triglycerides, vitamin E, and free fatty acids were assayed. Hepatic total cholesterol was lowest in GSP diet and …
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Array-based genomic diversity measures portray Mus musculus phylogenetic and genealogical relationships, and detect genetic variation among C57Bl/6J mice and between tissues of the same mouse
… and genealogy. Variation detected between C57BL/6J mice is consistent with previous reports of variants within this strain. Putative genetic variation detected between and within tissues indicates somatic mosaicism. Genotype differences detected within a mouse are a complex mixture of …
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