Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 176 for “"C57BL/6 mice"”.
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The Discriminative Stimulus Properties of the Atypical Antipsychotic Clozapine in C57BL/6 Mice
… Clozapine (2.5 mg/kg) drug discrimination in C57BL/6 mice may selectively screen atypical antipsychotic drugs. Previous data show that the atypical antipsychotics olanzapine, risperidone, ziprasidone but not the typical antipsychotic haloperidol fully substitutes for clozapine. The present …
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Age and Gender Effects on Strain Response and Biomechanical Performance of C57BL/6 Mice
… bone with aging has become an area of interest. C57Bl/6 mice have been commonly used in various studies to investigate the changes in a bone with aging. In this study, C57Bl/6 mice were divided into three age groups: 6 months old, 12 months old and 22 months old. Each age group consisted of 6-7 …
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Light-At-Night and Mood: Examining The Role Of Sex In C57Bl/6 Mice
… would interfere with the circadian rhythm of C57Bl/6 mice and induce both depressive-like and anxiety-like behaviours and that there would be sex-specific differences. Animals were either singly or group housed for a three week period where locomotor activity was measured. After this period …
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The effects of calorie restriction and aging on natural killer cells in c57bl/6 mice
… cells in aged (22 mo) calorie restricted (CR) C57Bl/6 mice. NK cells are innate immune cells capable of killing tumor or virus-infected cells. We used flow cytometry to analyze NK cell maturation in young ad libitum (AL) fed, young CR, aged AL, and aged CR mice. Aged CR mice had significantly …
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A role for Dazl in commitment to gametogenic fate in embryonic germ cells of C57BL/6 mice
… terminal differentiating process of meiosis. In mice, as XX germ cells enter meiosis around Embryonic days 13.5-14.5 (E13.5-E14.5), they form meiotic figures and down-regulate pluripotency markers. XY germ cells enter proliferation arrest between E13.5 and E16.5, which is accompanied by a …
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Citrobacter rodentium induced liver changes in C57BL/6 mice : animal model of acute inflammatory stress and injury
… dysregulation, and susceptibility to injury in C57BL/6 mice were investigated. For the first time, we show altered liver pathology during the early course of C. rodentium infection, characterized by periportal necrosis indicative of thrombic ischemic injury, correlating with distinct circulating …
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Hepatic Apo E mRNA Levels in BALB/c and C57BL/6 Mice Fed Different Levels and Types of Oil
… by level of dietary lipids in female BALB/c mice. Differences were revealed with all five primer pairs tested. Nine fragments were isolated, cloned, partially sequenced and compared to the Genbank data base. Sequence analyses identified Apolipoprotein E, P450-15-$\alpha$-hydroxylase (Cyp 2a4) …
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Hepatic Apo E mRNA levels in BALB/c and C57BL/6 mice fed different levels and types of oil
… by level of dietary lipids in female BALB/c mice. Differences were revealed with all five primer pairs tested. Nine fragments were isolated, cloned, partially sequenced and compared to the Genbank data base. Sequence analyses identified Apolipoprotein E, P450-15-$\alpha$-hydroxylase (Cyp 2a4) …
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Effects of fructan source and degree of polymerization on intestinal barrier function and histomorphology characteristics in obese C57BL/6 mice
… in an obese mouse model. Obese, 18-wk old, C57BL/6 mice were randomized to high-fat (45% of kcal) diets containing 5% cellulose, 10% cellulose, 10% short-chain fructooligosaccharides (scFOS) or 10% inulin and fed for 28 d. Distal ileum, cecum, and colon samples were collected for Ussing …
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The Effects of Early Postnatal PCP Administration on Performance in Locomotor Activity, Reference Memory, and Working Memory Tasks in C57BL/6 Mice
… effects of early postnatal PCP administration in C57BL/6 mice. Mouse pups received daily administrations of either 10.0 mg/kg PCP or saline on postnatal (PN) days 5-15. After weaning, pups were assessed in locomotor activity, a reference memory task in the Morris water maze, and a spatial delayed …
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The differential effects of short-term physical exercise, environmental enrichment and their combination, and short- and long-term environmental enrichment on behavior and associated molecular changes in the brain of C57BL/6 mice
… behaviors in 4-, 9- and 14-month-old C57BL/6 mice using an established behavioral battery. Changes in the expression of hippocampal genes, microglial and astrocyte numbers in the dentate gyrus, and T cell subsets in the cervical lymph nodes were also analyzed. Results: We found that …
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Investigating the role of IL-4/IL-13 signalling through the IL-4 receptor alpha (IL-4Rα) on keratinocytes in murine models of Leishmania major and Schistosoma mansoni
… IL-4 secreted early during L. major infection in mice, can drive a Th1 response by instructing dendritic cells to produce IL-12. Additionally, keratinocytes at the site of L. major infection in C57BL/6 mice, were postulated to be the source of the IL-4. We investigated if IL-4/IL-13 signalling via …
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Characterization of the effects of Interferon gamma protein-10 (CXCL10) against the protozoan parasite Leishmania amazonesis
… progressive disease in most inbred strains of mice. We have previously shown that L. amazonensis-infected C57BL/6 mice have profound impairments in expression of pro-inflammatory cytokines, chemokines and in activation of antigen-specific CD4+ T cells. These impairments are independent of IL-4. …
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The role of host and microbial factors in the pathogenesis of chronic schistosomiasis in mice
… Factor 2 (Batf2) gene in 129Sv (Batf2-/- ) mice resulted in alteration of the intestinal microbial composition and reduced granulomatous inflammatory immune response. These changes associated with rescue from pre-mature mortality and improved fitness of Batf2-/- mice during chronic …
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Development of prostrate cancer vaccine using PAP as target antigen
… peptides using the transgenic HHDII/DR1 and C57Bl/6 mice. The PAP-114-128 (15-mer) peptide was shown to elicit CD4+ and CD8+ T-cell-specific responses in C57Bl/6 mice. Furthermore, when immunised in a DNA vector format (ImmunoBody), PAP-114-128 was able to prevent and reduce the growth of …
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Role of the NLRP3 Inflammasome in bacterial keratitis
… and ATCC 19660) and S. aureus (31 and 38) and C57BL/6 mice with P. aeruginosa (6294 and 6206) and S. aureus (31 and 38). MCC950 (NLRP3 inflammasome inhibitor) or MCC950 + gentamicin or sterile phosphate buffer saline (PBS) was administered as topical drops (10µL of 100µM) or intraperitoneal …
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FVIII Immunity : early events and tolerance mechanisms to FVIII
… antibodies by treating hemophilia A Balb/c and C57BL/6 mice with repetitive FVIII infusions. We observed that the C57BL/6 mice developed higher FVIII antibody titers than the Balb/c mice. Our results suggest that differences in the cytokine immune responses due to FVIII in Balb/c and C57BL/6 …
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Upper-respiratory infection triggers experimental autoimmune encephalomyelitis onset in autoimmune prone t-cell receptor transgenic mice
… line. To test this hypothesis we infected 2D2 mice and monitored for symptoms of inflammatory demyelination (EAE). Clinical and histological EAE was observed in ~29.2% of infected 2D2 mice which closely resembles the incidence of upper-respiratory infection-induced relapse in MS patients. …
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The Mouse Magnetic Compass
… (RPM) and the magnetite based mechanism (MBM). C57BL/6 laboratory mice can rely on directional information from the magnetic field to position their nests and to solve a water maze task. The primary objective of this research was to characterize the magnetic compass of C57BL/6 laboratory mice in …
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Exogenous mesenchymal stromal cells in osteochondral repair
… injury model were investigated in young C57Bl/6 mice, aged C57Bl/6 mice and GNL3 heterozygote mice. MSC treatment was associated with improved osteochondral tissue repair in young C57Bl/6 mice but this was more limited in aged C57BL/6 mice and GNL3 heterozygote mice. Cage activity …
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